OSCR

Flunarizine changes microRNA expression in cell cultures and in a mouse model of spinal muscular atrophy.

Overview

Authors: Emeline Bon1, Perrine Delers1, Florent Dumont2,3, Badih Salman1,4, Delphine Sapaly1, Franck Letourneur2, Anne-Sophie Armand1,5, Suzie Lefebvre1
  1. Université Paris Cité, Inserm, HealthFex, 75006 Paris, France
  2. Genomic Facility, Université Paris Cité, Institut Cochin, INSERM, CNRS, Paris, France
  3. UMS Ingénierie et Plateformes au Service de l’Innovation Thérapeutique, Université Paris-Saclay, Orsay, France
  4. Present Address: Genethon, Université Paris-Saclay, University Evry, Inserm, Genethon, Integrare Research Unit UMR_S951, 91000 Evry, France
  5. Present Address: Université Paris Cité, INSERM UMR-U1151, CNRS UMR-8253, Institut Necker Enfants Malades, Team 8, Paris, France
Journal: Scientific reports, volume 16, issue 1, article 26166
Dates: received 6 March 2026; accepted 2 June 2026; published online 8 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-56607-1 · PMID 42260294 · PMCID PMC13490423 · OpenAlex W7163823737
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: fMRI & imaging
Keywords: Spinal muscular atrophy, Neurodegeneration, Flunarizine, microRNAs, miR-128, HIPK2, Cell biology, Diseases, Genetics, Molecular biology, Neuroscience
MeSH: Flunarizine*, Gene Expression Regulation*, MicroRNAs*, Muscular Atrophy, Spinal*, Animals, Carrier Proteins, Cell Line, Disease Models, Animal, Fibroblasts, Humans, Mice, Survival of Motor Neuron 1 Protein (* major topic)
Topic: Neurogenetic and Muscular Disorders Research (Genetics, Medicine), according to OpenAlex
Funding: French National Agency for Research - ANR
Citations: not cited yet (Europe PMC); 103 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-56607-1.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 11 keywords, 12 MeSH terms, 1 funder, 103 references.

Cite

This paper

Bon, E., Delers, P., Dumont, F., Salman, B., Sapaly, D., Letourneur, F., Armand, A.-S., & Lefebvre, S. (2026). Flunarizine changes microRNA expression in cell cultures and in a mouse model of spinal muscular atrophy. Scientific reports, 16(1), 26166. https://doi.org/10.1038/s41598-026-56607-1

BibTeX

@article{bon2026flunarizine,
author = {Bon, Emeline and Delers, Perrine and Dumont, Florent and Salman, Badih and Sapaly, Delphine and Letourneur, Franck and Armand, Anne-Sophie and Lefebvre, Suzie},
title = {{Flunarizine changes microRNA expression in cell cultures and in a mouse model of spinal muscular atrophy}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {26166},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-56607-1},
url = {https://doi.org/10.1038/s41598-026-56607-1},
pmid = {42260294},
pmcid = {PMC13490423}
}

RIS

TY - JOUR
AU - Bon, Emeline
AU - Delers, Perrine
AU - Dumont, Florent
AU - Salman, Badih
AU - Sapaly, Delphine
AU - Letourneur, Franck
AU - Armand, Anne-Sophie
AU - Lefebvre, Suzie
TI - Flunarizine changes microRNA expression in cell cultures and in a mouse model of spinal muscular atrophy
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/08
VL - 16
IS - 1
SP - 26166
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-56607-1
UR - https://doi.org/10.1038/s41598-026-56607-1
LA - en
ER -

CSL-JSON

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"issued": {
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