OSCR

Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma.

Overview

Authors: Hunter R. Underhill1,2,3, Drew L. Sellers4, Sabine Hellwig5, Hediyeh Baradaran2, Mary P. Bronner3,6, Alun Thomas7, Sarah Menacho8, Christian J. Davidson6, Rachna Malani8, Andrew Farrell9, Michael Karsy8, David A. Nix3, Yingqi Zhang1, Laura A. Boatz1, Joe Mendez8, Lindsay Burt10, Donald Cannon10, Charlie S. Dean3, Brion E. Harrison1, Samuel Stevenson1, Kinga Aitken11, Stefan M. Pulst11, Howard Colman3,8, Randy L. Jensen3,8
ORCID iDs: Michael Karsy
  1. Department of Pediatrics, Division of Medical Genetics, University of Utah,Salt Lake City, UT USA
  2. Department of Radiology, University of Utah,Salt Lake City, UT USA
  3. Huntsman Cancer Institute, University of Utah,Salt Lake City, UT USA
  4. Department of Bioengineering, University of Washington,Seattle, WA USA
  5. ARUP Laboratories,Salt Lake City, UT USA
  6. Department of Pathology, University of Utah,Salt Lake City, UT USA
  7. Department of Internal Medicine, Division of Epidemiology, University of Utah,Salt Lake City, UT USA
  8. Department of Neurological Surgery, University of Utah,Salt Lake City, UT USA
  9. Department of Human Genetics, University of Utah,Salt Lake City, UT USA
  10. Department of Radiation Oncology, University of Utah,Salt Lake City, UT USA
  11. Department of Neurology, University of Utah,Salt Lake City, UT USA
Institutions: University of Utah (United States); University of Washington (United States)
Journal: NPJ precision oncology, volume 10, issue 1, article 314
Dates: received 25 October 2025; accepted 12 May 2026; published online 22 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41698-026-01496-w · PMID 42174019 · PMCID PMC13470201 · OpenAlex W7162079044
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning, Evoked potentials, Connectivity, Smoothing, state filtering, decompositions
Keywords: Biomarkers, Cancer, Oncology
Topic: Cancer Genomics and Diagnostics (Cancer Research, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NIH (R37CA246183, R01NS118247, R35NS127253)
Citations: not cited yet (Europe PMC); 68 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41698-026-01496-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 24 authors, 3 keywords, 1 funder, 68 references.

Cite

This paper

Underhill, H. R., Sellers, D. L., Hellwig, S., Baradaran, H., Bronner, M. P., Thomas, A., Menacho, S., Davidson, C. J., Malani, R., Farrell, A., Karsy, M., Nix, D. A., Zhang, Y., Boatz, L. A., Mendez, J., Burt, L., Cannon, D., Dean, C. S., Harrison, B. E., . . . Jensen, R. L. (2026). Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma. NPJ precision oncology, 10(1), 314. https://doi.org/10.1038/s41698-026-01496-w

BibTeX

@article{underhill2026molecular,
author = {Underhill, Hunter R. and Sellers, Drew L. and Hellwig, Sabine and Baradaran, Hediyeh and Bronner, Mary P. and Thomas, Alun and Menacho, Sarah and Davidson, Christian J. and Malani, Rachna and Farrell, Andrew and Karsy, Michael and Nix, David A. and Zhang, Yingqi and Boatz, Laura A. and Mendez, Joe and Burt, Lindsay and Cannon, Donald and Dean, Charlie S. and Harrison, Brion E. and Stevenson, Samuel and Aitken, Kinga and Pulst, Stefan M. and Colman, Howard and Jensen, Randy L.},
title = {{Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma}},
journal = {NPJ precision oncology},
year = {2026},
month = may,
volume = {10},
number = {1},
pages = {314},
publisher = {Nature Publishing Group},
issn = {2397-768X},
doi = {10.1038/s41698-026-01496-w},
url = {https://doi.org/10.1038/s41698-026-01496-w},
pmid = {42174019},
pmcid = {PMC13470201}
}

RIS

TY - JOUR
AU - Underhill, Hunter R.
AU - Sellers, Drew L.
AU - Hellwig, Sabine
AU - Baradaran, Hediyeh
AU - Bronner, Mary P.
AU - Thomas, Alun
AU - Menacho, Sarah
AU - Davidson, Christian J.
AU - Malani, Rachna
AU - Farrell, Andrew
AU - Karsy, Michael
AU - Nix, David A.
AU - Zhang, Yingqi
AU - Boatz, Laura A.
AU - Mendez, Joe
AU - Burt, Lindsay
AU - Cannon, Donald
AU - Dean, Charlie S.
AU - Harrison, Brion E.
AU - Stevenson, Samuel
AU - Aitken, Kinga
AU - Pulst, Stefan M.
AU - Colman, Howard
AU - Jensen, Randy L.
TI - Molecular features unique to circulating tumor DNA enable the tumor-naïve liquid biopsy of glioblastoma
T2 - NPJ precision oncology
J2 - NPJ Precis Oncol
PY - 2026
DA - 2026/05/22
VL - 10
IS - 1
SP - 314
SN - 2397-768X
PB - Nature Publishing Group
DO - 10.1038/s41698-026-01496-w
UR - https://doi.org/10.1038/s41698-026-01496-w
LA - en
ER -

CSL-JSON

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