OSCR

RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain.

Overview

Authors: Anis Shahnaee1, Christine S Liu1, Tony Ngo1, Carter R Palmer1, Derya Ziomek1, Chris Park1, Valerie P Tan1, Natalia L Jimenez1, Jerold Chun1
ORCID iDs: Christine S Liu, Tony Ngo, Derya Ziomek, Valerie P Tan, Natalia L Jimenez, Jerold Chun
  1. Center for Neurologic Diseases, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA USA
Institutions: Sanford Burnham Prebys Medical Discovery Institute (United States)
Journal: Communications biology, volume 9, issue 1, article 506
Dates: received 2 September 2025; accepted 16 February 2026; published online 3 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-09759-9 · PMID 41772081 · PMCID PMC13065774 · OpenAlex W7133344806
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Alzheimer's disease, Transcriptomics
MeSH: Alternative Splicing*, Alzheimer Disease*, Brain*, RNA Isoforms*, RNA Splicing*, Female, Humans, Single-Cell Analysis (* major topic)
Topic: RNA Research and Splicing (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NIA NIH HHS (R01 AG065541, R01 AG071465); U.S. Department of Defense (United States Department of Defense) (W81XWH-21-1-0642)
Citations: not cited yet (Europe PMC); 79 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s42003-026-09759-9.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 2 keywords, 8 MeSH terms, 2 funders, 76 references.

Cite

This paper

Shahnaee, A., Liu, C. S., Ngo, T., Palmer, C. R., Ziomek, D., Park, C., Tan, V. P., Jimenez, N. L., & Chun, J. (2026). RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain. Communications biology, 9(1), 506. https://doi.org/10.1038/s42003-026-09759-9

BibTeX

@article{shahnaee2026rna,
author = {Shahnaee, Anis and Liu, Christine S and Ngo, Tony and Palmer, Carter R and Ziomek, Derya and Park, Chris and Tan, Valerie P and Jimenez, Natalia L and Chun, Jerold},
title = {{RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain}},
journal = {Communications biology},
year = {2026},
month = mar,
volume = {9},
number = {1},
pages = {506},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-09759-9},
url = {https://doi.org/10.1038/s42003-026-09759-9},
pmid = {41772081},
pmcid = {PMC13065774}
}

RIS

TY - JOUR
AU - Shahnaee, Anis
AU - Liu, Christine S
AU - Ngo, Tony
AU - Palmer, Carter R
AU - Ziomek, Derya
AU - Park, Chris
AU - Tan, Valerie P
AU - Jimenez, Natalia L
AU - Chun, Jerold
TI - RNA isoform diversity, splicing variants and switching in single cells of the Alzheimer's disease brain
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/03/03
VL - 9
IS - 1
SP - 506
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-09759-9
UR - https://doi.org/10.1038/s42003-026-09759-9
LA - en
ER -

CSL-JSON

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"language": "en",
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