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Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant.

Overview

Authors: Benjamin R. Kraemer1, Gwangbeom Heo1, Che-Hong Chen1, Daria Mochly-Rosen1
ORCID iDs: Benjamin R. Kraemer, Gwangbeom Heo, Daria Mochly-Rosen
  1. Department of Chemical and Systems Biology, Stanford University School of Medicine,Stanford, CA USA
Institutions: Stanford University (United States)
Journal: Communications biology, volume 9, issue 1, article 597
Dates: received 8 October 2024; accepted 25 February 2026; published online 14 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-09845-y · PMID 41832353 · PMCID PMC13133146 · OpenAlex W7135393640
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), epilepsy (population), developmental (subfield)
Methods: Smoothing, state filtering, decompositions
Keywords: Enzymes, Mechanisms of disease, Disease model, Metabolic pathways, Neurodevelopmental disorders
MeSH: Aldehyde Dehydrogenase*, Aldehydes*, Epilepsy*, Animals, Child, Disease Models, Animal, Humans, Mice, Mutation (* major topic)
Topic: Metabolism and Genetic Disorders (Clinical Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NIAAA NIH HHS (R01 AA011147)
Citations: cited by 1 paper (Europe PMC); 44 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s42003-026-09845-y.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 5 keywords, 9 MeSH terms, 1 funder, 43 references.

Cite

This paper

Kraemer, B. R., Heo, G., Chen, C.-H., & Mochly-Rosen, D. (2026). Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant. Communications biology, 9(1), 597. https://doi.org/10.1038/s42003-026-09845-y

BibTeX

@article{kraemer2026increased,
author = {Kraemer, Benjamin R. and Heo, Gwangbeom and Chen, Che-Hong and Mochly-Rosen, Daria},
title = {{Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant}},
journal = {Communications biology},
year = {2026},
month = mar,
volume = {9},
number = {1},
pages = {597},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-09845-y},
url = {https://doi.org/10.1038/s42003-026-09845-y},
pmid = {41832353},
pmcid = {PMC13133146}
}

RIS

TY - JOUR
AU - Kraemer, Benjamin R.
AU - Heo, Gwangbeom
AU - Chen, Che-Hong
AU - Mochly-Rosen, Daria
TI - Increased susceptibility to 4-HNE-induced toxicity and impaired development in a model of ALDH4A1-deficient pediatric epilepsy carrying the S352L variant
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/03/14
VL - 9
IS - 1
SP - 597
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-09845-y
UR - https://doi.org/10.1038/s42003-026-09845-y
LA - en
ER -

CSL-JSON

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"container-title": "Communications biology",
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