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Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission.

Overview

Authors: Jeannette Schmidt1,2,3,4, Ângela S. Inácio1,2,3, Joana Ferreira1,2,3,4, Débora Serrenho1,2,3, Renato Socodato5, Nuno Beltrão1,2,3, Luís F. Ribeiro1,2,3,4, Paulo Pinheiro1,2,6, João B. Relvas5,7, Ana Luisa Carvalho1,2,6
ORCID iDs: Joana Ferreira, Nuno Beltrão, Luís F. Ribeiro, Ana Luisa Carvalho
  1. CNC—Center for Neuroscience and Cell Biology, University of Coimbra,Coimbra, Portugal
  2. CiBB–Centre for Innovative Biomedicine and Biotechnology, University of Coimbra,Coimbra, Portugal
  3. Institute for Interdisciplinary Research, University of Coimbra,Coimbra, Portugal
  4. Present Address: Multidisciplinary Institute of Ageing (MIA-Portugal) & CiBB—Center for Innovative Biomedicine and Biotechnology, University of Coimbra,Coimbra, Portugal
  5. i3S - Institute of Research and Innovation in Health and IBMC—Institute for Molecular and Cell Biology (IBMC), University of Porto,Porto, Portugal
  6. Department of Life Sciences, University of Coimbra,Coimbra, Portugal
  7. Department of Biomedicine, Faculty of Medicine of the University of Porto,Porto, Portugal
Institutions: University of Coimbra (Portugal); Universidade do Porto (Portugal)
Journal: Communications biology, volume 9, issue 1, article 640
Dates: received 24 March 2025; accepted 6 March 2026; published online 20 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-09884-5 · PMID 41862576 · PMCID PMC13168625 · OpenAlex W7139008437
Open access: gold, a free copy (OpenAlex)
Status: code verified (how the code is found and verified)
Categories: human (organism), rat (organism), cellular / molecular (subfield)
Methods: Evoked potentials, fMRI & imaging
Keywords: Molecular neuroscience, Developmental disorders, Synaptic transmission
MeSH: GTPase-Activating Proteins*, Neurons*, Receptors, AMPA*, Synapses*, Synaptic Transmission*, Animals, Hippocampus, Humans, Rats, Receptors, N-Methyl-D-Aspartate (* major topic)
Topic: Neuroscience and Neuropharmacology Research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: “la Caixa” Foundation (LCF/PR/HP20/52300003)
Citations: cited by 1 paper (Europe PMC); 92 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Zenodo 18776119

License: CC-BY-4.0
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Size: 5 files
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
  • 30 September 2026: the link answers (HTTP 200)
At the source:

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1038/s42003-026-09884-5.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 3 keywords, 10 MeSH terms, 1 funder, 92 references.

Cite

This paper

Schmidt, J., Inácio, Â. S., Ferreira, J., Serrenho, D., Socodato, R., Beltrão, N., Ribeiro, L. F., Pinheiro, P., Relvas, J. B., & Carvalho, A. L. (2026). Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission. Communications biology, 9(1), 640. https://doi.org/10.1038/s42003-026-09884-5

BibTeX

@article{schmidt2026neuronal,
author = {Schmidt, Jeannette and Inácio, Ângela S. and Ferreira, Joana and Serrenho, Débora and Socodato, Renato and Beltrão, Nuno and Ribeiro, Luís F. and Pinheiro, Paulo and Relvas, João B. and Carvalho, Ana Luisa},
title = {{Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission}},
journal = {Communications biology},
year = {2026},
month = mar,
volume = {9},
number = {1},
pages = {640},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-09884-5},
url = {https://doi.org/10.1038/s42003-026-09884-5},
pmid = {41862576},
pmcid = {PMC13168625}
}

RIS

TY - JOUR
AU - Schmidt, Jeannette
AU - Inácio, Ângela S.
AU - Ferreira, Joana
AU - Serrenho, Débora
AU - Socodato, Renato
AU - Beltrão, Nuno
AU - Ribeiro, Luís F.
AU - Pinheiro, Paulo
AU - Relvas, João B.
AU - Carvalho, Ana Luisa
TI - Neuronal ARHGAP8 controls synapse structure and AMPA receptor-mediated synaptic transmission
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/03/20
VL - 9
IS - 1
SP - 640
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-09884-5
UR - https://doi.org/10.1038/s42003-026-09884-5
LA - en
ER -

CSL-JSON

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