Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier.
Overview
- Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA USA
- Present Address: Sir Peter Mansfield Imaging Centre, School of Medicine & School of Chemistry, University of Nottingham, University Park, Nottingham, UK
- Harvard-MIT Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA USA
- Present Address: Department of Chemistry and Biochemistry, California State University, Fresno, CA 93740 USA
- Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA USA
- Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA USA
- McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA USA
Abstract
The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- doi:10.5061/
dryad.tqjq2bwb7 , at Dryad; found in DataCite
Data availability statement
The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- no repository, dataset or request procedure was recognized in it
Read it in the paper: doi.org/10.1038/s42003-026-09951-x.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 3 keywords, 8 MeSH terms, 4 funders, 48 references.
Cite
This paper
Dawson, M., Bricault, S., Harvey, P., Wisniowska, A., Wei, H., Wang, X., García-García, G., Kaise, T., Kamm, R. D., & Jasanoff, A. (2026). Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier. Communications biology, 9(1), 744. https://
BibTeX
@article{dawson2026quant
author = {Dawson, Miranda and Bricault, Sarah and Harvey, Peter and Wisniowska, Agata and Wei, He and Wang, Xun and García-García, Gracia and Kaise, Takashi and Kamm, Roger D and Jasanoff, Alan},
title = {{Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier}},
journal = {Communications biology},
year = {2026},
month = apr,
volume = {9},
number = {1},
pages = {744},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/
url = {https://
pmid = {41935136},
pmcid = {PMC13230606}
}
RIS
TY - JOUR
AU - Dawson, Miranda
AU - Bricault, Sarah
AU - Harvey, Peter
AU - Wisniowska, Agata
AU - Wei, He
AU - Wang, Xun
AU - García-García, Gracia
AU - Kaise, Takashi
AU - Kamm, Roger D
AU - Jasanoff, Alan
TI - Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/
VL - 9
IS - 1
SP - 744
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1038/
"type": "article-journal",
"title": "Quantitative comparison of methods for widespread delivery of small molecules across the blood-brain barrier",
"container-title": "Communications biology",
"author": [
{
"family": "Dawson",
"given": "Miranda"
},
{
"family": "Bricault",
"given": "Sarah"
},
{
"family": "Harvey",
"given": "Peter"
},
{
"family": "Wisniowska",
"given": "Agata"
},
{
"family": "Wei",
"given": "He"
},
{
"family": "Wang",
"given": "Xun"
},
{
"family": "García-García",
"given": "Gracia"
},
{
"family": "Kaise",
"given": "Takashi"
},
{
"family": "Kamm",
"given": "Roger D"
},
{
"family": "Jasanoff",
"given": "Alan"
}
],
"container-title-short":
"volume": "9",
"issue": "1",
"page": "744",
"DOI": "10.1038/
"PMID": "41935136",
"PMCID": "PMC13230606",
"ISSN": "2399-3642",
"publisher": "Nature Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
4
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1126/sciadv.aed4944 [code]
- Focused ultrasound blood-brain barrier opening reveals a paradoxical remote metabolic response in the primate brain.Journal: Science advancesIn common: structural MRI / diffusion, 4 references
- [2] doi:10.1002/adhm.202504849
- ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models.Journal: Advanced healthcare materialsIn common: author Roger D Kamm
- [3] doi:10.1016/j.crmeth.2026.101427
- Noninvasive focal gene transfer of chemogenetic proteins in the primate brain.Journal: Cell reports methodsIn common: 3 references
- [4] doi:10.1007/s10237-026-02070-w
- Modification of a poroelastic model for zero porosity: finite element implementation and investigation of fluid mechanics in the perivascular space.Journal: Biomechanics and modeling in mechanobiologyIn common: 3 references
- [5] doi:10.1038/s41467-026-71835-9
- In vivo imaging of central nervous system fluid spaces using synchrotron radiation-based micro computed tomography.Journal: Nature communicationsIn common: 3 references
- [6] doi:10.2147/nss.s618511
- Associations Between Obstructive Sleep Apnea, Macro-Scale Glymphatic Coupling, and Episodic Memory Impairment in Middle-Aged and Older Adults.Journal: Nature and science of sleepIn common: 3 references
- [7] doi:10.3389/fncel.2026.1830831
- Brief mechanical pulses induce sustained intracellular L-lactate production in astrocytes.Journal: Frontiers in cellular neuroscienceIn common: 3 references
- [8] doi:10.1177/0271678x261455452 [code]
- Meningeal CSF transport varies across parasagittal dura subregions with age in humans.Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismIn common: structural MRI / diffusion, 2 references
- [9] doi:10.1126/sciadv.aeb0404 [code]
- MR-AIV reveals in vivo brain-wide fluid flow with physics-informed AI.Journal: Science advancesIn common: structural MRI / diffusion, 2 references
- [10] doi:10.1186/s12987-026-00782-w
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Journal: Fluids and barriers of the CNSIn common: rat, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.