Functional dissociation of language and theory of mind in the developing superior temporal lobe.
The 3 matches · 1 of them tie a paragraph to a whole file, not to given lines: a weak match, whose lines are not tinted
- [1] § Methods › Statistics and Reproducibility ↔ Hiersche_2026_CommBio_rmANOVA_code.R, the whole file · a weak match · score 0.92 · rm ANOVA, anova_test, cohens_d, pairwise_t_test, fROIs, outliers
- [2] § Results › Connectivity fingerprints that underlie STL function › Connectivity fingerprints for language vs. ToM in the STL ↔ Hiersche_2026_CommBio_stats.m, lines 506–534 · score 0.67 · connectivity fingerprints, adult models, Lang LH, Lang RH, pbh, beta
- [3] § Methods › Defining maximally responsive regions and overlap ↔ Hiersche_2026_CommBio_stats.m, lines 243–267 · score 0.59 · fROI, 1–5 %, hotspot, thresholds, dice, Ns
Paper
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The authors' code
MATLAB · 632 lines · 30 KB · CC-BY-4.0 · 2 matches
- %% KJH 03/182026
- % code for reproducing all statistics in Hiersche, Osher, Saygin (2026)
- % Functional Dissociation of Language and Theory of Mind in the Developing
- % Superior Temporal Lobe. Communications Biology
- % code and data are all available on https://github.com/SayginLab/STL_languageToM
- % most analyses were performed in matlab (version 2024a)
- % some anlayses were performed in R Studio
- %% load all data
- % this is the selectivity & overlap data data
- load('df_LangToM_STL_github.mat')
- %% Do fROIs show selectivity to lang or ToM?
- % stats for table S1
- % output of interest is table_lang and table_ToM
- % column 1: t-stat (dof) for selectivity vs 0 one-tailed t-test
- % column 2: p value (*p<0.05, **p0.05 after bonferroni-holm correction
- % for 7 comparisons)
- % column 3: Cohen's D [95% CI]
- % the columns are the 7 networks of interest in the network variable
- group='kidsEnTx'; % or adultsEnTx or the EnNs versions for supplemental
- for i=1:length(networks)
- [~,plangv0(i,1),~,stats]=ttest(df.langsel1.(group)(:,i),0,'tail','right');
- [~,ptomv0(i,1),~,stats]=ttest(df.tomsel1.(group)(:,i),0,'tail','right');
- end
- for i=1:length(networks)
- ROI=i;
- [~,p,~,stats]=ttest(df.langsel1.(group)(:,i),0,'tail','right');
- results.Lang.(group)(i,1)=stats.tstat;
- results.Lang.(group)(i,2)=p;
- results.Lang.(group)(i,3)=stats.df;
- d=meanEffectSize(df.langsel1.(group)(:,i),'Effect','cohen');
- results.Lang.(group)(i,5)=table2array(d(1,1));
- ci.lang(i,:)=table2array(d(1,2));
- % ToM v O
- [~,p,~,stats]=ttest(df.tomsel1.(group)(:,i),0,'tail','right');
- results.ToM.(group)(i,1)=stats.tstat;
- results.ToM.(group)(i,2)=p;
- results.ToM.(group)(i,3)=stats.df;
- d=meanEffectSize(df.tomsel1.(group)(:,i),'Effect','cohen');
- results.ToM.(group)(i,5)=table2array(d(1,1));
- ci.ToM(i,:)=table2array(d(1,2));
- end
- % do multiple comparison correction
- %results.LANGvToM.(group)(:,4)=bonf_holm(results.LANGvToM.(group)(:,2));
- results.Lang.(group)(:,4)=bonf_holm(results.Lang.(group)(:,2));
- results.ToM.(group)(:,4)=bonf_holm(results.ToM.(group)(:,2));
- % prep the Lang table
- for i=1:length(networks)
- pval=results.Lang.(group)(i,2);
- pval_bf=results.Lang.(group)(i,4);
- dval=results.Lang.(group)(i,5);
- table_lang{i,1} = sprintf('%2.2f (%d)',results.Lang.(group)(i,1),results.Lang.(group)(i,3));
- if pval < 0.05 && pval_bf > 0.05
- table_lang{i,2} = sprintf('%0.5g*',pval);
- elseif pval <0.05 && pval_bf <0.05
- table_lang{i,2} = sprintf('%0.5g**',pval);
- else
- table_lang{i,2} = sprintf('%0.5g',pval);
- end
- table_lang{i,3} = sprintf('%2.2f, [%2.2f,%2.2f] ',dval,ci.lang(i,1),ci.lang(i,2));
- end
- % prep the ToM table for i=1:length(plotROIs)
- for i=1:length(networks)
- pval=results.ToM.(group)(i,2);
- pval_bf=results.ToM.(group)(i,4);
- dval=results.ToM.(group)(i,5);
- table_ToM{i,1} = sprintf('%2.2f (%d)',results.ToM.(group)(i,1),results.ToM.(group)(i,3));
- if pval < 0.05 && pval_bf > 0.05
- table_ToM{i,2} = sprintf('%0.5g*',pval);
- elseif pval <0.05 && pval_bf <0.05
- table_ToM{i,2} = sprintf('%0.5g**',pval);
- else
- table_ToM{i,2} = sprintf('%0.5g',pval);
- end
- table_ToM{i,3} = sprintf('%2.2f, [%2.2f,%2.2f] ',dval,ci.ToM(i,1),ci.ToM(i,2));
- end
- tablev0=[table_lang;table_ToM];
- %% Plot Figure 1A
- group='kidsEnTx'; % or 'kidsEnTx' 'adultsEnTx'
- meanselkid=[nanmean(df.langsel.(group)(:,[1,2]),'all'),nanmean(df.tomsel.(group)(:,[1,2]),'all');nanmean(df.langsel.(group)(:,[6,7]),'all'),nanmean(df.tomsel.(group)(:,[6,7]),'all');nanmean(df.langsel.(group)(:,[5]),'all'),nanmean(df.tomsel.(group)(:,[5]),'all');nanmean(df.langsel.(group)(:,[10]),'all'),nanmean(df.tomsel.(group)(:,[10]),'all')];
- steselkid=[nanste(nanmean(df.langsel.(group)(:,[1,2]),2)),nanste(nanmean(df.tomsel.(group)(:,[1,2]),2));nanste(nanmean(df.langsel.(group)(:,[6,7]),2)),nanste(nanmean(df.tomsel.(group)(:,[6,7]),2));nanste(nanmean(df.langsel.(group)(:,[5]),2)),nanste(nanmean(df.tomsel.(group)(:,[5]),2));nanste(nanmean(df.langsel.(group)(:,[10]),2)),nanste(nanmean(df.tomsel.(group)(:,[10]),2))];
- errorbar_groups(meanselkid',steselkid')
- hold on
- scatter(ones([length(df.langsel.(group)(:,1)),1])*1.05,nanmean(df.langsel.(group)(:,[1,2]),2),'k')
- scatter(ones([length(df.langsel.(group)(:,1)),1])*3.05,nanmean(df.langsel.(group)(:,[6,7]),2),'k')
- scatter(ones([length(df.langsel.(group)(:,1)),1])*5.05,nanmean(df.langsel.(group)(:,5),2),'k')
- scatter(ones([length(df.langsel.(group)(:,1)),1])*7.05,df.langsel.(group)(:,10),'k')
- scatter(ones([length(df.tomsel.(group)(:,1)),1])*1.95,nanmean(df.tomsel.(group)(:,[1,2]),2),'k')
- scatter(ones([length(df.tomsel.(group)(:,1)),1])*3.95,nanmean(df.tomsel.(group)(:,[6,7]),2),'k')
- scatter(ones([length(df.tomsel.(group)(:,1)),1])*5.95,nanmean(df.tomsel.(group)(:,5),2),'k')
- scatter(ones([length(df.tomsel.(group)(:,1)),1])*7.95,nanmean(df.tomsel.(group)(:,10),2),'k')
- legend({'Lang','ToM'})
- xticklabels({'LH Lang','RH Lang','LH TPJ','RH TPJ'})
- ylabel({'Selectivity'})
- title(group)
- ylim([-1 2])
- %% Are language and ToM regions functionally distinct
- % this code if for reproducing Table 1
- % to make table S2, use motmatch groups
- % to make table S3, use the EnNs groups
- % prep the data for rmANOVA:
- clear sels task sub fwd aovtable
- group='adultsmotmatchEnTx'; subgroup='adultsmotmatch'; % sub group just needs to have the number of subjects
- sels=[df.langsel1.(group);df.tomsel1.(group)];
- task=[repmat({'lang'},[length(sels)/2,1]);repmat({'tom'},[length(sels)/2,1])]; %lang 0, ToM 1
- sub=[df.subs.(subgroup);df.subs.(subgroup)]; % subject
- if contains(group,'kids')
- fwd=[mean(df.motion.(subgroup).mean_fwd.lang,2);df.motion.(subgroup).mean_fwd.partlycloudy_rc_new(:,1)]; % fwd
- else
- % for adults
- fwd=[mean(df.motion.(subgroup).lang,2);df.motion.(subgroup).pc]; % fwd
- end
- aovtable=table(sub,task,sels,fwd);
- % see R studio script for calculating rmANOVAs
- %% table S4, differentiation with age
- % outcome of cross sectional correlation is in rlang and rtom
- % column 1: r value
- % column 2: p value
- % column 3: p value after bonferroni holm correction
- % rows are the 7 networks
- % longitudinal results are in ltp12: language changes across TPs; ttp12:
- % ToM changes across TPs
- group='kidsEnTx';con='EnTx'; %
- for i=1:length(networks)
- [rlang(i,1),rlang(i,2)]=partialcorr(df.langsel1.(group)(:,i),df.ages.kids,mean(df.motion.kids.mean_fwd.lang,2),'rows','complete');
- [rtom(i,1),rtom(i,2)]=partialcorr(df.tomsel1.(group)(:,i),df.ages.kids,df.motion.kids.mean_fwd.partlycloudy_rc_new(:,1),'rows','complete');
- [~,pl(i,1),~,stats]=ttest(df.langsel1.(['kidslongTP1' con])(:,i),df.langsel1.(['kidslongTP2' con])(:,i));
- ltp12(i,1)=strcat('t(' ,string(stats.df), ')=',string(round(stats.tstat,2)) );
- [~,pt(i,1),~,stats]=ttest(df.tomsel1.(['kidslongTP1' con])(:,i),df.tomsel1.(['kidslongTP2' con])(:,i));
- ttp12(i,1)=strcat('t(' ,string(stats.df), ')=',string(round(stats.tstat,2)) );
- end
- rlang(:,3)=bonf_holm(rlang(:,2));
- rtom(:,3)=bonf_holm(rtom(:,2));
- %scatter(df.xsec.ages,tomsel1.xsec(:,1))
- rtable=[rlang(:,1:2),rtom(:,1:2)];
- %% figure 1B overlap
- kidgroup='kidsEnTx';
- adultgroup='adultsEnTx';
- thresholds={'1%','2%','3%','4%','5%','10%','20%','30%'};
- for i=1:length(thresholds)
- sgtitle('LH STL')
- subplot(2,4,i)
- histogram(df.dice.(kidgroup).dice.LH_STL(:,i),'NumBins',8)
- hold on
- histogram(df.dice.(adultgroup).dice.LH_STL(:,i),'NumBins',8)
- title(thresholds{i})
- ylabel('subject count')
- xlabel('overlap')
- legend('off')
- ylim([0 50])
- xlim([0 .60])
- end
- figure
- thresholds={'1%','2%','3%','4%','5%','10%','20%','30%'};
- for i=1:length(thresholds)
- sgtitle('RH STL')
- subplot(2,4,i)
- histogram(df.dice.(kidgroup).dice.RH_STL(:,i),'NumBins',8)
- hold on
- histogram(df.dice.(adultgroup).dice.RH_STL(:,i),'NumBins',8)
- title(thresholds{i})
- ylabel('subject count')
- xlabel('overlap')
- legend('off')
- ylim([0 50])
- xlim([0 .60])
- end
- %% figure 1C: dice overlap
- group='kidsEnTx'; % change to adultsEnTx to plot adults
- prct={'1','2','3','4','5','10','20','30'};
- for i=1:length(prct)
- meandice=squeeze(mean(df.diceperm.(group).real_dice));
- %sig_dice=1-(sum(df.diceperm.(group).pval_dice(:,:,i)<0.05)./size(df.spin.(group).pval_dice,1));
- subplot(2,4,i)
- imagesc([meandice(1:2,i),meandice(3:4,i)])
- hold on
- title(sprintf('%s',prct{i}))
- colorbar
- sgtitle(group,'FontSize',25)
- clim([0 1])
- xticks([1 2])
- %xticklabels({'LH Lang','RH Lang'})
- yticks([1 2])
- %yticklabels({'LH ToM','RH ToM'})
- set(gcf,'color','w'); % set graph parameters
- set(gca,'box','off','LineWidth',1.5,'FontSize',20);
- set(gca,'TickLabelInterpreter','none') % interpreter none is helpful for plotting names with '_'
- set(gcf,'renderer','painters'); % your plots are made slower but prettier
- end
- %% overlap stats in text
- % adult results listed in text
- % mean and std of overlap
- mean(df.dice.adultsEnTx.dice.LH_STL)
- std(df.dice.adultsEnTx.dice.LH_STL)
- % percent overlap similar to change
- sum(squeeze(df.diceperm.adultsEnTx.pval_dice(:,1,:))>=0.05)/length(df.subs.adults)
- mean(df.dice.adultsEnTx.dice.RH_STL)
- std(df.dice.adultsEnTx.dice.RH_STL)
- sum(squeeze(df.diceperm.adultsEnTx.pval_dice(:,4,:))>=0.05)/length(df.subs.adults)
- % LH to RH overlap
- LHlang_RHToM=[squeeze(mean(df.diceperm.adultsEnTx.real_dice(:,3,:))),squeeze(std(df.diceperm.adultsEnTx.real_dice(:,3,:)))]
- sum(squeeze(df.diceperm.adultsEnTx.pval_dice(:,3,:))>=0.05)/length(df.subs.adults)
- % kids results
- mean(df.dice.kidsEnTx.dice.LH_STL)
- std(df.dice.kidsEnTx.dice.LH_STL)
- sum(squeeze(df.diceperm.kidsEnTx.pval_dice(:,1,:))>=0.05)/length(df.subs.kids)
- mean(df.dice.kidsEnTx.dice.RH_STL)
- std(df.dice.kidsEnTx.dice.RH_STL)
- sum(squeeze(df.diceperm.kidsEnTx.pval_dice(:,4,:))>=0.05)/length(df.subs.kids)
- LHlang_RHToM=[squeeze(mean(df.diceperm.kidsEnTx.real_dice(:,3,:))),squeeze(std(df.diceperm.kidsEnTx.real_dice(:,3,:)))]
- sum(squeeze(df.diceperm.kidsEnTx.pval_dice(:,3,:))>=0.05)/length(df.subs.kids)
- %% overlap stats in table 2
- % output of interest is ov
- % column 1: mean (std) % similar change for LH overlap
- % column 2: mean (std) % similar change for RH overlap
- % column 3: mean (std) % similar change for LH lang-RH ToM overlap
- % the rows are the different threshold for making hotspot fROI: 1%-5%,
- % 10%,20%,30%
- % change to motmatch for Table S5
- % change the group to EnNs for Table S6
- group='adultsEnNs';group1='adults';
- for i=1:8
- meanov=nanmean(df.dice.(group).dice.LH_STL(:,i));
- stdov=nanstd(df.dice.(group).dice.LH_STL(:,i));
- perc_chance=(sum(squeeze(df.diceperm.(group).pval_dice(:,1,i))>=0.05)./length(df.subs.(group1)))*100;
- ov{i,1} = sprintf('%2.3f (%2.3f); %2.1f%%',meanov,stdov,perc_chance);
- meanov=nanmean(df.dice.(group).dice.RH_STL(:,i));
- stdov=nanstd(df.dice.(group).dice.RH_STL(:,i));
- perc_chance=(sum(squeeze(df.diceperm.(group).pval_dice(:,4,i))>=0.05)./length(df.subs.(group1)))*100;
- ov{i,2} = sprintf('%2.3f (%2.3f); %2.1f%%',meanov,stdov,perc_chance);
- meanov=nanmean(df.diceperm.(group).real_dice(:,3,i));
- stdov=nanstd(df.diceperm.(group).real_dice(:,3,i));
- perc_chance=(sum(squeeze(df.diceperm.(group).pval_dice(:,3,i))>=0.05)./length(df.subs.(group1)))*100;
- ov{i,3} = sprintf('%2.3f (%2.3f); %2.1f%%',meanov,stdov,perc_chance);
- end
- %% overlap and age changes
- % table S7
- % for table S8, use EnNs results
- % this is cross sectional results: results.ovcor
- % column 1: r value
- % column 2: pval
- % column 3: bonferrnoi-holm p val
- % rows: thresholds, 1-5%, 10%, 20%, 30%
- sec={'LH_STL','RH_STL'};
- group='kidsEnNs'; group1='kids';
- motion=nanmean([df.motion.(group1).mean_fwd.lang,df.motion.(group1).mean_fwd.partlycloudy_rc_new],2);
- for s=1:length(sec)
- for i=1:8
- [r,p]=partialcorr(df.dice.(group).dice.(sec{s})(:,i),df.ages.(group1),motion);
- results.ovcor.(group).(sec{s})(i,1)=r;
- results.ovcor.(group).(sec{s})(i,2)=p;
- [r,p]=partialcorr(squeeze(df.diceperm.(group).real_dice(:,3,i)),df.ages.(group1),motion);
- results.ovcor.(group).LHlangRHToM(i,1)=r;
- results.ovcor.(group).LHlangRHToM(i,2)=p;
- end
- end
- results.ovcor.(group).RH_STL(:,3)=bonf_holm(results.ovcor.(group).RH_STL(:,2));
- results.ovcor.(group).LH_STL(:,3)=bonf_holm(results.ovcor.(group).LH_STL(:,2));
- results.ovcor.(group).LHlangRHToM(:,3)=bonf_holm(results.ovcor.(group).LHlangRHToM(:,2));
- % this is the longitudinal results: results.ovttest.long
- % table results are ov_tp
- % column 1: t stat (dof)
- % column 2: p value
- % column 3: cohen's D
- % column 4: cohen's d 95% CI
- % rows are the 8 thresholds (1%-5%,10%,20%,30%)
- groupTP1='kidslongTP1EnNs';
- groupTP2='kidslongTP2EnNs';
- sec={'LH_STL','RH_STL'};
- for s=1:length(sec)
- for i=1:8
- [~,p,~,stats]=ttest(df.dice.(groupTP1).dice.(sec{s})(:,i),df.dice.(groupTP2).dice.(sec{s})(:,i));
- cd=meanEffectSize(df.dice.(groupTP1).dice.(sec{s})(:,i),df.dice.(groupTP2).dice.(sec{s})(:,i),'Effect','cohen');
- results.ovttest.long.(sec{s})(i,1)=stats.tstat;
- results.ovttest.long.(sec{s})(i,2)=stats.df;
- results.ovttest.long.(sec{s})(i,3)=p;
- ci=string(round(table2array(cd(1,2)),2));
- ov_tp.(sec{s}){i,1} = sprintf('%2.2f (%d)',stats.tstat,stats.df);
- ov_tp.(sec{s}){i,2} = sprintf('%2.2f',p);
- ov_tp.(sec{s}){i,3} = sprintf('%2.2f,',table2array(cd(1,1)));
- ov_tp.(sec{s}){i,4} = sprintf('[%s,%s]',ci(1),ci(2));
- end
- end
- results.ovttest.long.LH_STL(:,4)=bonf_holm( results.ovttest.long.LH_STL(:,3));
- results.ovttest.long.RH_STL(:,4)=bonf_holm( results.ovttest.long.RH_STL(:,3));
- for i=1:8
- [~,p,~,stats]=ttest(df.diceperm.(groupTP1).real_dice(:,i),squeeze(df.diceperm.(groupTP2).real_dice(:,3,i)));
- cd=meanEffectSize(df.diceperm.(groupTP1).real_dice(:,i),squeeze(df.diceperm.(groupTP2).real_dice(:,3,i)),'Effect','cohen');
- results.ovttest.long.LHlang_RHToM(i,1)=stats.tstat;
- results.ovttest.long.LHlang_RHToM(i,2)=stats.df;
- results.ovttest.long.LHlang_RHToM(i,3)=p;
- ci=string(round(table2array(cd(1,2)),2));
- ov_tp.LHlang_RHToM{i,1} = sprintf('%2.2f (%d)',stats.tstat,stats.df);
- ov_tp.LHlang_RHToM{i,2} = sprintf('%2.2f',p);
- ov_tp.LHlang_RHToM{i,3} = sprintf('%2.2f,',table2array(cd(1,1)));
- ov_tp.LHlang_RHToM{i,4} = sprintf('[%s,%s]',ci(1),ci(2));
- end
- %% predicting adult STL activation
- group='kids'; % 'kids'
- % set the group to either kids or adults depending on stats you are
- % trying to reproduce
- % language activation prediction
- % get mean and std of self prediction (using a subject's own connectivity
- mean(cfmodelresults.(group).selfprediction.lh.R2_EnTx_lang)
- std(cfmodelresults.(group).selfprediction.lh.R2_EnTx_lang)
- mean(cfmodelresults.(group).selfprediction.rh.R2_EnTx_lang)
- std(cfmodelresults.(group).selfprediction.rh.R2_EnTx_lang)
- % get mean and std of other prediction (using each other subs connectivty)
- mean(cfmodelresults.(group).otherpred.lh.R2_EnTx_lang,'all')
- std(mean(cfmodelresults.(group).otherpred.lh.R2_EnTx_lang,2))
- mean(cfmodelresults.(group).otherpred.rh.R2_EnTx_lang,'all')
- std(mean(cfmodelresults.(group).otherpred.rh.R2_EnTx_lang,2))
- % self v other t-test: do fischer z transform
- [~,p,~,stats]=ttest(atanh(cfmodelresults.(group).selfprediction.lh.R2_EnTx_lang),mean(atanh(cfmodelresults.(group).otherpred.lh.R2_EnTx_lang),2))
- meanEffectSize(atanh(cfmodelresults.(group).selfprediction.lh.R2_EnTx_lang),mean(atanh(cfmodelresults.(group).otherpred.lh.R2_EnTx_lang),2),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.(group).selfprediction.rh.R2_EnTx_lang),mean(atanh(cfmodelresults.(group).otherpred.rh.R2_EnTx_lang),2))
- meanEffectSize(atanh(cfmodelresults.(group).selfprediction.rh.R2_EnTx_lang),mean(atanh(cfmodelresults.(group).otherpred.rh.R2_EnTx_lang),2),Effect="cohen")
- % ToM activation prediction
- % get mean and std of self prediction (using a subject's own connectivity
- mean(cfmodelresults.(group).selfprediction.lh.R2_MntlPain_ToM)
- std(cfmodelresults.(group).selfprediction.lh.R2_MntlPain_ToM)
- mean(cfmodelresults.(group).selfprediction.rh.R2_MntlPain_ToM)
- std(cfmodelresults.(group).selfprediction.rh.R2_MntlPain_ToM)
- % get mean and std of other prediction (using each other subs connectivty)
- mean(cfmodelresults.(group).otherpred.lh.R2_MntlPain_ToM,'all')
- std(mean(cfmodelresults.(group).otherpred.lh.R2_MntlPain_ToM,2))
- mean(cfmodelresults.(group).otherpred.rh.R2_MntlPain_ToM,'all')
- std(mean(cfmodelresults.(group).otherpred.rh.R2_MntlPain_ToM,2))
- % self v other t-test: do fischer z transform
- [~,p,~,stats]=ttest(atanh(cfmodelresults.(group).selfprediction.lh.R2_MntlPain_ToM),mean(atanh(cfmodelresults.(group).otherpred.lh.R2_MntlPain_ToM),2))
- meanEffectSize(atanh(cfmodelresults.(group).selfprediction.lh.R2_MntlPain_ToM),mean(atanh(cfmodelresults.(group).otherpred.lh.R2_MntlPain_ToM),2),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.(group).selfprediction.rh.R2_MntlPain_ToM),mean(atanh(cfmodelresults.(group).otherpred.rh.R2_MntlPain_ToM),2))
- meanEffectSize(atanh(cfmodelresults.(group).selfprediction.rh.R2_MntlPain_ToM),mean(atanh(cfmodelresults.(group).otherpred.rh.R2_MntlPain_ToM),2),Effect="cohen")
- %% model fit and age correlations
- [r,p]=partialcorr(atanh(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang),df.ages.kidscf,df.motion.kidscf.restmot.fwd)
- [r,p]=partialcorr(atanh(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang),df.ages.kidscf,df.motion.kidscf.restmot.fwd)
- [r,p]=partialcorr(atanh(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM),df.ages.kidscf,df.motion.kidscf.restmot.fwd)
- [r,p]=partialcorr(atanh(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM),df.ages.kidscf,df.motion.kidscf.restmot.fwd)
- %% model fit across TPs
- TP1self.lh.lang=diag(cfmodelresults.kidsTP1.selfprediction.lh.R2_EnTx_lang);
- TP1self.rh.lang=diag(cfmodelresults.kidsTP1.selfprediction.rh.R2_EnTx_lang);
- TP1self.lh.ToM=diag(cfmodelresults.kidsTP1.selfprediction.lh.R2_MntlPain_ToM);
- TP1self.rh.ToM=diag(cfmodelresults.kidsTP1.selfprediction.rh.R2_MntlPain_ToM);
- mean(TP1self.lh.lang)
- std(TP1self.lh.lang)
- mean(TP1self.rh.lang)
- std(TP1self.rh.lang)
- mean(TP1self.lh.ToM)
- std(TP1self.lh.ToM)
- mean(TP1self.rh.ToM)
- std(TP1self.rh.ToM)
- [~,tp2_idx]=intersect(df.subs.kidscf,df.subs.kidscfTP2);
- TP2self.lh.lang=cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang(tp2_idx);
- TP2self.rh.lang=cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang(tp2_idx);
- TP2self.lh.ToM=cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM(tp2_idx);
- TP2self.rh.ToM=cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM(tp2_idx);
- [~,p,~,stats]=ttest(atanh(TP1self.lh.lang),atanh(TP2self.lh.lang))
- meanEffectSize(atanh(TP1self.lh.lang),atanh(TP2self.lh.lang),Effect='cohen')
- [~,p,~,stats]=ttest(atanh(TP1self.rh.lang),atanh(TP2self.rh.lang))
- meanEffectSize(atanh(TP1self.rh.lang),atanh(TP2self.rh.lang),Effect='cohen')
- [~,p,~,stats]=ttest(atanh(TP1self.lh.ToM),atanh(TP2self.lh.ToM))
- meanEffectSize(atanh(TP1self.lh.ToM),atanh(TP2self.lh.ToM),Effect='cohen')
- [~,p,~,stats]=ttest(atanh(TP1self.rh.ToM),atanh(TP2self.rh.ToM))
- meanEffectSize(atanh(TP1self.rh.ToM),atanh(TP2self.rh.ToM),Effect='cohen')
- %% Plot Figure 2A
- group='adults'; subs=length(df.subs.adultscf);
- % change to kids and df.subs.kidscf when plotting kids
- clear predcorr predcorr_b predcorr_other
- predcorr(:,1)=cfmodelresults.(group).selfprediction.lh.R2_EnTx_lang;
- predcorr(:,2)=cfmodelresults.(group).selfprediction.rh.R2_EnTx_lang;
- predcorr(:,3)=cfmodelresults.(group).selfprediction.lh.R2_MntlPain_ToM;
- predcorr(:,4)=cfmodelresults.(group).selfprediction.rh.R2_MntlPain_ToM;
- predcorr_other(:,1)=mean(cfmodelresults.(group).otherpred.lh.R2_EnTx_lang,2);
- predcorr_other(:,2)=mean(cfmodelresults.(group).otherpred.rh.R2_EnTx_lang,2);
- predcorr_other(:,3)=mean(cfmodelresults.(group).otherpred.lh.R2_MntlPain_ToM,2);
- predcorr_other(:,4)=mean(cfmodelresults.(group).otherpred.rh.R2_MntlPain_ToM,2);
- predcorr_b(:,1)=cfmodelresults.(group).wrongBpred.lh.R2_EnTx_lang;
- predcorr_b(:,2)=cfmodelresults.(group).wrongBpred.rh.R2_EnTx_lang;
- predcorr_b(:,3)=cfmodelresults.(group).wrongBpred.lh.R2_MntlPain_ToM;
- predcorr_b(:,4)=cfmodelresults.(group).wrongBpred.rh.R2_MntlPain_ToM;
- xvals=errorbar_groups([mean(predcorr);mean(predcorr_other);mean(predcorr_b)],[ste(predcorr);ste(predcorr_other);ste(predcorr_b)]);
- hold on
- for i=1:length(xvals)
- xval=[ones([subs,1]).*(xvals(i)-0.9),ones([subs,1]).*xvals(i),ones([subs,1]).*(xvals(i)+0.9)];
- yval=[predcorr(:,i),predcorr_other(:,i),predcorr_b(:,i)];
- scatter(xval,yval,'k')
- for s=1:subs
- plot(xval(s,:),yval(s,:),'r')
- end
- end
- title([ group 'Model Performance'])
- legend({'Self','Other','Opposite Task Betas'})
- ylabel('Correlation Real and Predicted')
- xticklabels({'Lang LH','Lang RH','ToM LH','ToM RH'})
- set(gcf,'color','w');
- set(gca,'box','off','LineWidth',2.5,'FontSize',15,'Layer', 'Top');
- %% Figure 2B: TP1 vs TP2
- subs=length(df.subs.kidscfTP1);
- xvals=errorbar_groups([mean(TP1self.lh.lang),mean(TP1self.rh.lang),mean(TP1self.lh.ToM),mean(TP1self.rh.ToM);mean(TP2self.lh.lang),mean(TP2self.rh.lang),mean(TP2self.lh.ToM),mean(TP2self.rh.ToM)],[ste(TP1self.lh.lang),ste(TP1self.rh.lang),ste(TP1self.lh.ToM),ste(TP1self.rh.ToM);ste(TP2self.lh.lang),ste(TP2self.rh.lang),ste(TP2self.lh.ToM),ste(TP2self.rh.ToM)]);
- hold on
- title('Kids Longitudinal Model Fit')
- xticklabels({'LH Lang','RH Lang','LH ToM','RH ToM'})
- %xticklabels({'LH Lang','RH Lang'}); %;,'LH ToM','RH ToM'})
- ylabel('Predicted-Actual Correlation')
- scatter(ones([subs,1])*1.95,TP2self.lh.lang,'k')
- scatter(ones([subs,1])*1.05,TP1self.lh.lang,'k')
- scatter(ones([subs,1])*3.95,TP2self.rh.lang,'k')
- scatter(ones([subs,1])*3.05,TP1self.rh.lang,'k')
- scatter(ones([subs,1])*5.95,TP2self.lh.ToM,'k')
- scatter(ones([subs,1])*5.05,TP1self.lh.ToM,'k')
- scatter(ones([subs,1])*7.95,TP2self.rh.ToM,'k')
- scatter(ones([subs,1])*7.05,TP1self.rh.ToM,'k')
- for s=1:subs
- plot([1.05,1.95],[TP1self.lh.lang(s,1),TP2self.lh.lang(s,1)],'r')
- plot([3.05,3.95],[TP1self.rh.lang(s,1),TP2self.rh.lang(s,1)],'r')
- plot([5.05,5.95],[TP1self.lh.ToM(s,1),TP2self.lh.ToM(s,1)],'r')
- plot([7.05,7.95],[TP1self.rh.ToM(s,1),TP2self.rh.ToM(s,1)],'r')
- end
- legend({'TP1','TP2'})
- set(gcf,'color','w');
- set(gca,'box','off','LineWidth',2.5,'FontSize',15,'Layer', 'Top');
- %% comparing across models for predicting lang and ToM
- % adults lang v ToM
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM),Effect="cohen")
- % children lang v ToM
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM),Effect="cohen")
- %% Connectivity fingerprints for Language vs. ToM in the STL
- [r_beta,p_beta]=corr([meanbetas.kids.R2_EnTx_lang.lh,meanbetas.kids.R2_EnTx_lang.rh,meanbetas.kids.R2_MntlPain_ToM.lh,meanbetas.kids.R2_MntlPain_ToM.rh,meanbetas.adults.R2_EnTx_lang.lh,meanbetas.adults.R2_EnTx_lang.rh,meanbetas.adults.R2_MntlPain_ToM.lh,meanbetas.adults.R2_MntlPain_ToM.rh],'Type','Pearson','rows','pairwise');
- p_beta(p_beta==1)=0;
- ptri=tril(p_beta);
- pval=squareform(p_beta)';
- pbf=bonf_holm(pval);
- pbf_square=squareform(pbf);
- % r beta & p_beta (rows and columns) is in the order of
- % kids lang lh
- % kids lang rh
- % kids ToM lh
- % kids ToM rh
- % adults lang lh
- % adults lang rh
- % adults ToM lh
- % adults ToM rh
- % look at adult to adult models
- adults_r=r_beta(5:8,5:8);
- adults_pbh=pbf_square(5:8,5:8);
- adults_sig=r_beta(5:8,5:8).*(pbf_square(5:8,5:8)<0.05);
- kids_r=r_beta(1:4,1:4);
- kids_pbh=pbf_square(1:4,1:4);
- kids_sig=r_beta(1:4,1:4).*(pbf_square(1:4,1:4)<0.05);
- ak_r=r_beta(5:8,1:4);
- ak_pbh=pbf_square(5:8,1:4);
- ak_sig=r_beta(5:8,1:4).*(pbf_square(5:8,1:4)<0.05);
- %% Figure 2C
- imagesc(r_beta)
- hold on
- colorbar
- clim([0 1])
- colormap(turbo)
- title('Correlation of Betas Across Models')
- xticklabels({'Kids LH Lang','Kids RH Lang','Kids LH ToM','Kids RH ToM', ...
- 'Adults LH Lang','Adults RH Lang','Adults LH ToM','Adults RH ToM'})
- yticklabels({'Kids LH Lang','Kids RH Lang','Kids LH ToM','Kids RH ToM', ...
- 'Adults LH Lang','Adults RH Lang','Adults LH ToM','Adults RH ToM'})
- %% What contributes to these differences across domains?
- lang='R2_EnTx_lang';
- ToM='R2_MntlPain_ToM';
- for i=1:145
- % kids LH
- [~,p,~,stats]=ttest(betas.kids.(lang).lh(i,:),betas.kids.(ToM).lh(i,:));
- betacomp.kids_lh(i,2)=p;
- betacomp.kids_lh(i,1)=stats.tstat;
- % kids RH
- [~,p,~,stats]=ttest(betas.kids.(lang).rh(i,:),betas.kids.(ToM).rh(i,:));
- betacomp.kids_rh(i,2)=p;
- betacomp.kids_rh(i,1)=stats.tstat;
- % adults LH
- [~,p,~,stats]=ttest(betas.adults.(lang).lh(i,:),betas.adults.(ToM).lh(i,:));
- betacomp.adults_lh(i,2)=p;
- betacomp.adults_lh(i,1)=stats.tstat;
- %adults RH
- [~,p,~,stats]=ttest(betas.adults.(lang).rh(i,:),betas.adults.(ToM).rh(i,:));
- betacomp.adults_rh(i,2)=p;
- betacomp.adults_rh(i,1)=stats.tstat;
- end
- betacomp.adults_rh(:,3)=bonf_holm(betacomp.adults_rh(:,2));
- betacomp.adults_lh(:,3)=bonf_holm(betacomp.adults_lh(:,2));
- betacomp.kids_rh(:,3)=bonf_holm(betacomp.kids_rh(:,2));
- betacomp.kids_lh(:,3)=bonf_holm(betacomp.kids_lh(:,2));
- % get the % of predictors that significantly differ across models
- % in betacomp, the rows are the 145 regions
- % column 1 is t stat
- % column 2 is pval
- % column 3 is bonferroni-holm pval
- (sum(betacomp.adults_lh(:,3)<0.05)/145)*100
- (sum(betacomp.adults_rh(:,3)<0.05)/145)*100
- (sum(betacomp.kids_lh(:,3)<0.05)/145)*100
- (sum(betacomp.kids_rh(:,3)<0.05)/145)*100
- %% compare true models with using the wrong betas
- % adults
- mean(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang-cfmodelresults.adults.wrongBpred.lh.R2_EnTx_lang)
- std(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang-cfmodelresults.adults.wrongBpred.lh.R2_EnTx_lang)
- mean(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang-cfmodelresults.adults.wrongBpred.rh.R2_EnTx_lang)
- std(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang-cfmodelresults.adults.wrongBpred.rh.R2_EnTx_lang)
- mean(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM-cfmodelresults.adults.wrongBpred.lh.R2_MntlPain_ToM)
- std(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM-cfmodelresults.adults.wrongBpred.lh.R2_MntlPain_ToM)
- mean(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM-cfmodelresults.adults.wrongBpred.rh.R2_MntlPain_ToM)
- std(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM-cfmodelresults.adults.wrongBpred.rh.R2_MntlPain_ToM)
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.adults.wrongBpred.lh.R2_EnTx_lang))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.adults.wrongBpred.lh.R2_EnTx_lang),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.adults.wrongBpred.rh.R2_EnTx_lang))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.adults.wrongBpred.rh.R2_EnTx_lang),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM),atanh(cfmodelresults.adults.wrongBpred.lh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.lh.R2_MntlPain_ToM),atanh(cfmodelresults.adults.wrongBpred.lh.R2_MntlPain_ToM),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM),atanh(cfmodelresults.adults.wrongBpred.rh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.adults.selfprediction.rh.R2_MntlPain_ToM),atanh(cfmodelresults.adults.wrongBpred.rh.R2_MntlPain_ToM),Effect="cohen")
- % kids
- mean(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang-cfmodelresults.kids.wrongBpred.lh.R2_EnTx_lang)
- std(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang-cfmodelresults.kids.wrongBpred.lh.R2_EnTx_lang)
- mean(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang-cfmodelresults.kids.wrongBpred.rh.R2_EnTx_lang)
- std(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang-cfmodelresults.kids.wrongBpred.rh.R2_EnTx_lang)
- mean(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM-cfmodelresults.kids.wrongBpred.lh.R2_MntlPain_ToM)
- std(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM-cfmodelresults.kids.wrongBpred.lh.R2_MntlPain_ToM)
- mean(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM-cfmodelresults.kids.wrongBpred.rh.R2_MntlPain_ToM)
- std(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM-cfmodelresults.kids.wrongBpred.rh.R2_MntlPain_ToM)
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.kids.wrongBpred.lh.R2_EnTx_lang))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.lh.R2_EnTx_lang),atanh(cfmodelresults.kids.wrongBpred.lh.R2_EnTx_lang),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.kids.wrongBpred.rh.R2_EnTx_lang))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.rh.R2_EnTx_lang),atanh(cfmodelresults.kids.wrongBpred.rh.R2_EnTx_lang),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM),atanh(cfmodelresults.kids.wrongBpred.lh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.lh.R2_MntlPain_ToM),atanh(cfmodelresults.kids.wrongBpred.lh.R2_MntlPain_ToM),Effect="cohen")
- [~,p,~,stats]=ttest(atanh(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM),atanh(cfmodelresults.kids.wrongBpred.rh.R2_MntlPain_ToM))
- meanEffectSize(atanh(cfmodelresults.kids.selfprediction.rh.R2_MntlPain_ToM),atanh(cfmodelresults.kids.wrongBpred.rh.R2_MntlPain_ToM),Effect="cohen")
- %% For figure 3 and Figure S4
- % plot the top 10 most positive and top 10 most negative t stats in
- % betacomp for each hemisphere of kids & adults separately
- % for brain plotting code, please contanct [email hidden]
Hiersche_2026_CommBio_stats.m, under CC-BY-4.0 · at the source
Overview
- Department of Psychology, The Ohio State University,Columbus, OH USA
- Center for Cognitive and Behavioral Brain Imaging, The Ohio State University,Columbus, OH USA
Abstract
The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.
Repository
Its files are read in the Code ↔ Paper reader above, with 3 matches between paragraphs and lines of code.
Zenodo 19206150
Availability: 1 check, the latest on 29 September 2026: the link answers (HTTP 200)
- 29 September 2026: the link answers (HTTP 200)
2 files
- Hiersche_2026_CommBio_rm
ANOVA_code.R , R, 86 lines, 1 match - Hiersche_2026_CommBio_st
ats.m , MATLAB, 632 lines, 2 matches
Code availability statement
The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- it points to the authors' code: Zenodo 19206150
Read it in the paper: doi.org/10.1038/s42003-026-10040-2.
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
- 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
- 2 scripts, each with its path and the digest of its content;
- 3 matches between paragraphs of the paper and lines of the code (method lexical-v1);
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
Data
No dataset and no data link were found in the paper.
Code and data availability statement
The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- it points to the authors' code: Zenodo 19206150
Read it in the paper: doi.org/10.1038/s42003-026-10040-2.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 2 keywords, 11 MeSH terms, 1 funder, 70 references.
Cite
This paper
Hiersche, K. J., Osher, D. E., & Saygin, Z. M. (2026). Functional dissociation of language and theory of mind in the developing superior temporal lobe. Communications biology, 9(1), 558. https://
BibTeX
@article{hiersche2026fun
author = {Hiersche, Kelly J. and Osher, David E. and Saygin, Zeynep M.},
title = {{Functional dissociation of language and theory of mind in the developing superior temporal lobe}},
journal = {Communications biology},
year = {2026},
month = apr,
volume = {9},
number = {1},
pages = {558},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/
url = {https://
pmid = {42026127},
pmcid = {PMC13106660}
}
RIS
TY - JOUR
AU - Hiersche, Kelly J.
AU - Osher, David E.
AU - Saygin, Zeynep M.
TI - Functional dissociation of language and theory of mind in the developing superior temporal lobe
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/
VL - 9
IS - 1
SP - 558
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1038/
"type": "article-journal",
"title": "Functional dissociation of language and theory of mind in the developing superior temporal lobe",
"container-title": "Communications biology",
"author": [
{
"family": "Hiersche",
"given": "Kelly J."
},
{
"family": "Osher",
"given": "David E."
},
{
"family": "Saygin",
"given": "Zeynep M."
}
],
"container-title-short":
"volume": "9",
"issue": "1",
"page": "558",
"DOI": "10.1038/
"PMID": "42026127",
"PMCID": "PMC13106660",
"ISSN": "2399-3642",
"publisher": "Nature Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
23
]
]
}
}
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