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Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties.

Overview

Authors: Felix Preuss1,2, Martin Möck1, Mirko Witte1, Jochen F Staiger1
ORCID iDs: Felix Preuss, Jochen F Staiger
  1. Institute for Neuroanatomy, Universitätsmedizin Göttingen, Georg-August-Universität, Göttingen, Göttingen Germany
  2. Neurophysics Laboratory, Göttingen Campus Institute for Dynamics of Biological Networks (CIDBN), Göttingen, Germany
Institutions: Universitätsmedizin Göttingen (Germany); Göttingen Campus Institut für Dynamic biologischer Netzwerke (Germany); University of Göttingen (Germany)
Journal: Communications biology, volume 9, issue 1, article 756
Dates: received 12 August 2025; accepted 27 May 2026; published online 3 June 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s42003-026-10418-2 · PMID 42236552 · PMCID PMC13234287 · OpenAlex W7163426973
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: intracellular / patch clamp (modality), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials, Connectivity
Keywords: Neural circuits, Barrel cortex
MeSH: Interneurons*, Parvalbumins*, Somatostatin*, Vasoactive Intestinal Peptide*, Action Potentials, Animals, Mice, Patch-Clamp Techniques, Synapses (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: Deutsche Forschungsgemeinschaft (German Research Foundation) (STA 431/14-1, STA 431/21-1)
Citations: not cited yet (Europe PMC); 81 references in the paper

Abstract

Somatostatin (SST) expressing cells are powerful inhibitors of excitatory pyramidal neurons. It has been shown that SST cells are targeted by other inhibitory interneurons, namely parvalbumin- (PV) and vasoactive intestinal polypeptide- (VIP) expressing cells in various cortical regions. Subcellular distribution of PV and VIP synapses suggests differences in their modulation of action potential generation in postsynaptic SST cells. However, functional analyses if and to what extent individual neurons are able to change the output of postsynaptic targets are sparse. To test this, we use paired patch clamp recordings to analyze SST cell firing with and without presynaptic PV or VIP cell stimulation. Despite their enormous differences in unitary synaptic properties, individual PV and VIP cells both are able to significantly decrease action potential output in postsynaptic SST cells. However, testing two different action potential firing durations (1 s and 100 ms) in presynaptic cells, we do not observe significant differences in overall spike loss of PV to SST versus VIP to SST cell connections. Morphological analysis of putative contact sites (PCS) does not reveal differences in PCS location. We propose that individual GABAergic neurons are indeed able to modulate the firing output of SST neurons without principled cell type specificity.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

Zenodo 19664110

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 5 files, 0 scripts
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source:

Code availability

The original analysis code written in Signal 5 can be obtained on Zenodo. (10.5281/zenodo.19664110)

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability

Numerical source data underlying the graphs are provided as Numerical_Source_Data in the Supplemental data files. Any additional raw data can be obtained from the corresponding author upon reasonable request. The original data are available upon request form the corresponding author. See Reporting summary for details

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 2 keywords, 9 MeSH terms, 1 funder, 80 references.

Cite

This paper

Preuss, F., Möck, M., Witte, M., & Staiger, J. F. (2026). Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties. Communications biology, 9(1), 756. https://doi.org/10.1038/s42003-026-10418-2

BibTeX

@article{preuss2026cortical,
author = {Preuss, Felix and Möck, Martin and Witte, Mirko and Staiger, Jochen F},
title = {{Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties}},
journal = {Communications biology},
year = {2026},
month = jun,
volume = {9},
number = {1},
pages = {756},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-10418-2},
url = {https://doi.org/10.1038/s42003-026-10418-2},
pmid = {42236552},
pmcid = {PMC13234287}
}

RIS

TY - JOUR
AU - Preuss, Felix
AU - Möck, Martin
AU - Witte, Mirko
AU - Staiger, Jochen F
TI - Cortical PV and VIP interneurons similarly influence SST neuron output despite distinct unitary properties
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/06/03
VL - 9
IS - 1
SP - 756
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-10418-2
UR - https://doi.org/10.1038/s42003-026-10418-2
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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