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Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease.

Overview

Authors: Stephanie J Yang1, Andrew A Lin1,2, Hanfei Shen1, Laura W Pappalardo3, Griffin B Spychalski1,2, Jean Rosario4, Leah K Forsberg5, Kiera M Grant6, Joshua R Buser7, Rodolfo Savica5, Sid O’Bryant8, David T Jones5, Dennis W Dickson9, R Ross Reichard10, Aivi T Nguyen10, David F Meaney1, Bradley F Boeve5, Owen A Ross9, Pamela J McLean9, David Issadore1
  1. Department of Bioengineering, University of Pennsylvania, Philadelphia, PA USA
  2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
  3. Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA USA
  4. Department of Biology, University of Pennsylvania, Philadelphia, PA USA
  5. Department of Neurology, Mayo Clinic, Rochester, MN USA
  6. Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN USA
  7. Consonant Systems, LLC, Philadelphia, PA USA
  8. Health Science Center at Fort Worth, University of North Texas, Fort Worth, TX USA
  9. Department of Neuroscience, Mayo Clinic, Jacksonville, FL USA
  10. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN USA
Institutions: University of Pennsylvania (United States); Hospital of the University of Pennsylvania (United States); Mayo Clinic (United States); University of North Texas (United States); University of North Texas Health Science Center (United States); Mayo Clinic in Florida (United States)
Journal: Npj biosensing, volume 3, issue 1, article 19
Dates: received 25 September 2025; accepted 19 February 2026; published online 12 March 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s44328-026-00086-x · PMID 41836608 · PMCID PMC12982126 · OpenAlex W7135055733
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Connectivity
Keywords: Biological techniques, Neuroscience
Topic: Extracellular vesicles in disease (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Institutes of Health (U19 AG063911, P30 AG062677, U54 NS110435); Little Family Foundation; Ted Turner and Family Foundation; American Academy of Neurology/American Brain Foundation Cure One Cure Many Award; Harry T. Mangurian, Jr. Foundation
Citations: cited by 3 papers (Europe PMC); 109 references in the paper
Research resources: RRID:SCR_022380

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

doi:10.5061/dryad.612jm64j4

License: none: the authors keep all their rights
State: the link answers, verified on 30 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
  • 30 September 2026: the link answers (HTTP 200)
At the source: doi.org/10.5061/dryad.612jm64j4

Code availability statement

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Read it in the paper: doi.org/10.1038/s44328-026-00086-x.

Tracing map

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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

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Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s44328-026-00086-x.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 2 keywords, 5 funders, 102 references, 1 RRID.

Cite

This paper

Yang, S. J., Lin, A. A., Shen, H., Pappalardo, L. W., Spychalski, G. B., Rosario, J., Forsberg, L. K., Grant, K. M., Buser, J. R., Savica, R., O’Bryant, S., Jones, D. T., Dickson, D. W., Reichard, R. R., Nguyen, A. T., Meaney, D. F., Boeve, B. F., Ross, O. A., McLean, P. J., & Issadore, D. (2026). Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease. Npj biosensing, 3(1), 19. https://doi.org/10.1038/s44328-026-00086-x

BibTeX

@article{yang2026microfluidic,
author = {Yang, Stephanie J and Lin, Andrew A and Shen, Hanfei and Pappalardo, Laura W and Spychalski, Griffin B and Rosario, Jean and Forsberg, Leah K and Grant, Kiera M and Buser, Joshua R and Savica, Rodolfo and O’Bryant, Sid and Jones, David T and Dickson, Dennis W and Reichard, R Ross and Nguyen, Aivi T and Meaney, David F and Boeve, Bradley F and Ross, Owen A and McLean, Pamela J and Issadore, David},
title = {{Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease}},
journal = {Npj biosensing},
year = {2026},
month = mar,
volume = {3},
number = {1},
pages = {19},
publisher = {Springer Science+Business Media},
issn = {3004-8656},
doi = {10.1038/s44328-026-00086-x},
url = {https://doi.org/10.1038/s44328-026-00086-x},
pmid = {41836608},
pmcid = {PMC12982126}
}

RIS

TY - JOUR
AU - Yang, Stephanie J
AU - Lin, Andrew A
AU - Shen, Hanfei
AU - Pappalardo, Laura W
AU - Spychalski, Griffin B
AU - Rosario, Jean
AU - Forsberg, Leah K
AU - Grant, Kiera M
AU - Buser, Joshua R
AU - Savica, Rodolfo
AU - O’Bryant, Sid
AU - Jones, David T
AU - Dickson, Dennis W
AU - Reichard, R Ross
AU - Nguyen, Aivi T
AU - Meaney, David F
AU - Boeve, Bradley F
AU - Ross, Owen A
AU - McLean, Pamela J
AU - Issadore, David
TI - Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease
T2 - Npj biosensing
J2 - NPJ Biosens
PY - 2026
DA - 2026/03/12
VL - 3
IS - 1
SP - 19
SN - 3004-8656
PB - Springer Science+Business Media
DO - 10.1038/s44328-026-00086-x
UR - https://doi.org/10.1038/s44328-026-00086-x
LA - en
ER -

CSL-JSON

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