OSCR

Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi.

Overview

Authors: Chiara Gorrini1,2, Soode Jafari1, Gordon Duncan1, Bryan Snow1, Liam Hendrikse1, Louis McLoughlin2, Jillian Haight1, Andrew Wakeham1, Chantal Tobin1, Andrew Elia1, Paramesh Ramachandran1, Rhoda Law1, Bevan Gang1, Tsai-Ling Lu1, Isabel Morgado-Palacin1, Annick You-Ten1, Thorsten Berger1, Raffaella Sordella3, Tak W. Mak1,4,5,6
ORCID iDs: Tak W. Mak
  1. Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2M9, Canada
  2. School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
  3. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724
  4. Centre for Oncology and Immunology, Hong Kong Special Administrative Region of China, China
  5. Department of Pathology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong Special Administrative Region of China, China
  6. Departments of Immunology and Medical Biophysics, University of Toronto, Toronto, ON M5G 2C4, Canada
Institutions: University of Leeds (United Kingdom); University Health Network (Canada); Princess Margaret Cancer Centre (Canada); Cold Spring Harbor Laboratory (United States); University of Toronto (Canada); Queen Mary Hospital (China); University of Hong Kong (Hong Kong SAR China)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 13, article e2427242123
Dates: received 31 December 2024; accepted 10 February 2026; published online 23 March 2026; in print 31 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2427242123 · PMID 41871246 · PMCID PMC13038064 · OpenAlex W7140084074
Open access: hybrid, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), mouse (organism), other condition (population), developmental (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: tumor suppression, p53 splicing isoform, cancer
MeSH: Tumor Suppressor Protein p53*, Alternative Splicing, Animals, Embryonic Development, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Protein Isoforms (* major topic)
Journal subjects: Biological Sciences, Cell Biology
Topic: Cancer-related Molecular Pathways (Oncology, Medicine), according to OpenAlex
Funding: Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) (N/A)
Citations: not cited yet (Europe PMC); 47 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data and to no code of its authors: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2427242123.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 3 keywords, 11 MeSH terms, 1 funder, 45 references.

Cite

This paper

Gorrini, C., Jafari, S., Duncan, G., Snow, B., Hendrikse, L., McLoughlin, L., Haight, J., Wakeham, A., Tobin, C., Elia, A., Ramachandran, P., Law, R., Gang, B., Lu, T.-L., Morgado-Palacin, I., You-Ten, A., Berger, T., Sordella, R., & Mak, T. W. (2026). Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi. Proceedings of the National Academy of Sciences of the United States of America, 123(13), e2427242123. https://doi.org/10.1073/pnas.2427242123

BibTeX

@article{gorrini2026unveiling,
author = {Gorrini, Chiara and Jafari, Soode and Duncan, Gordon and Snow, Bryan and Hendrikse, Liam and McLoughlin, Louis and Haight, Jillian and Wakeham, Andrew and Tobin, Chantal and Elia, Andrew and Ramachandran, Paramesh and Law, Rhoda and Gang, Bevan and Lu, Tsai-Ling and Morgado-Palacin, Isabel and You-Ten, Annick and Berger, Thorsten and Sordella, Raffaella and Mak, Tak W.},
title = {{Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {13},
pages = {e2427242123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2427242123},
url = {https://doi.org/10.1073/pnas.2427242123},
pmid = {41871246},
pmcid = {PMC13038064}
}

RIS

TY - JOUR
AU - Gorrini, Chiara
AU - Jafari, Soode
AU - Duncan, Gordon
AU - Snow, Bryan
AU - Hendrikse, Liam
AU - McLoughlin, Louis
AU - Haight, Jillian
AU - Wakeham, Andrew
AU - Tobin, Chantal
AU - Elia, Andrew
AU - Ramachandran, Paramesh
AU - Law, Rhoda
AU - Gang, Bevan
AU - Lu, Tsai-Ling
AU - Morgado-Palacin, Isabel
AU - You-Ten, Annick
AU - Berger, Thorsten
AU - Sordella, Raffaella
AU - Mak, Tak W.
TI - Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/23
VL - 123
IS - 13
SP - e2427242123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2427242123
UR - https://doi.org/10.1073/pnas.2427242123
LA - en
ER -

CSL-JSON

{
"id": "10.1073/pnas.2427242123",
"type": "article-journal",
"title": "Unveiling the developmental and tumor-suppressive roles of the p53 variant p53psi",
"container-title": "Proceedings of the National Academy of Sciences of the United States of America",
"author": [
{
"family": "Gorrini",
"given": "Chiara"
},
{
"family": "Jafari",
"given": "Soode"
},
{
"family": "Duncan",
"given": "Gordon"
},
{
"family": "Snow",
"given": "Bryan"
},
{
"family": "Hendrikse",
"given": "Liam"
},
{
"family": "McLoughlin",
"given": "Louis"
},
{
"family": "Haight",
"given": "Jillian"
},
{
"family": "Wakeham",
"given": "Andrew"
},
{
"family": "Tobin",
"given": "Chantal"
},
{
"family": "Elia",
"given": "Andrew"
},
{
"family": "Ramachandran",
"given": "Paramesh"
},
{
"family": "Law",
"given": "Rhoda"
},
{
"family": "Gang",
"given": "Bevan"
},
{
"family": "Lu",
"given": "Tsai-Ling"
},
{
"family": "Morgado-Palacin",
"given": "Isabel"
},
{
"family": "You-Ten",
"given": "Annick"
},
{
"family": "Berger",
"given": "Thorsten"
},
{
"family": "Sordella",
"given": "Raffaella"
},
{
"family": "Mak",
"given": "Tak W."
}
],
"container-title-short": "Proc Natl Acad Sci U S A",
"volume": "123",
"issue": "13",
"page": "e2427242123",
"DOI": "10.1073/pnas.2427242123",
"PMID": "41871246",
"PMCID": "PMC13038064",
"ISSN": "0027-8424",
"publisher": "National Academy of Sciences",
"URL": "https://doi.org/10.1073/pnas.2427242123",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
23
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1016/j.xcrm.2024.101546
Targeting low levels of MIF expression as a potential therapeutic strategy for ALS.
Journal: Cell reports. Medicine
In common: other condition, mouse, 4 references
[2] doi:10.1038/s41467-024-45948-y
TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome.
Journal: Nature communications
In common: other condition, mouse, 4 references
[3] doi:10.1186/s12974-023-03007-1
CD4 T-cell aging exacerbates neuroinflammation in a late-onset mouse model of amyotrophic lateral sclerosis.
Journal: Journal of neuroinflammation
In common: other condition, mouse, 4 references
[4] doi:10.1038/s41467-025-62048-7 [code]
Hamsters with long COVID present distinct transcriptomic profiles associated with neurodegenerative processes in brainstem.
Journal: Nature communications
In common: other condition, 4 references
[5] doi:10.1186/s13024-025-00820-5 [code]
Multi-region brain transcriptomic analysis of amyotrophic lateral sclerosis reveals widespread RNA alterations and substantial cerebellum involvement.
Journal: Molecular neurodegeneration
In common: other condition, 4 references
[6] doi:10.1016/j.isci.2024.109601 [code]
Genomic analysis of human brain metastases treated with stereotactic radiosurgery reveals unique signature based on treatment failure.
Journal: iScience
In common: other condition, 4 references
[7] doi:10.1016/j.celrep.2024.114637
Autism-associated CHD8 controls reactive gliosis and neuroinflammation via remodeling chromatin in astrocytes.
Journal: Cell reports
In common: mouse, 4 references
[8] doi:10.1126/sciadv.ads4441 [code]
Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward.
Journal: Science advances
In common: other condition, 4 references
[9] doi:10.3390/ijms25137383 [code]
MMP-3 Knockout Induces Global Transcriptional Changes and Reduces Cerebral Infarction in Both Male and Female Models of Ischemic Stroke.
Journal: International journal of molecular sciences
In common: mouse, 4 references
[10] doi:10.3390/ijms252413382
Comprehensive Transcriptomic Analysis Reveals Cell-Type-Specific Roles of Human Odorant Receptors in Glioblastoma and the Tumor Microenvironment.
Journal: International journal of molecular sciences
In common: other condition, 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.

Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.