OSCR

AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder.

Overview

Authors: Valeria Lallai1, Samuel Kho2, A. C. Martin2,3, James P. Fowler1, Madison L. Roach1,4, Kevin Wang1, Kendyl N. Laumann1, Tyler G. Morris4, Mina Palaniappan1, Malia Bautista1, Allison S. Mogul1, Jinjutha E. Cheepluesak1, Bijay Shrestha2, Dhanaji M. Lade2,4, Julia E. Lagomarsino1, Vaishnavi Narayan2, Jayson Uffens2, Waldemar Lernhardt2, Saman Mirzaei2, Ian Jenkins2, Arturo R. Zavala4, Jonathan R. T. Lakey2,5,6, Robert Tinder2,3, Christie D. Fowler1
ORCID iDs: Valeria Lallai, Samuel Kho, Madison L. Roach, Bijay Shrestha, Dhanaji M. Lade, Arturo R. Zavala, Christie D. Fowler
  1. Department of Neurobiology and Behavior, University of California, Irvine, CA 92697
  2. GATC Health, Irvine, CA 92614
  3. C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506
  4. Department of Psychology, California State University, Long Beach, CA 90840
  5. Department of Surgery, University of California, Irvine, CA 92697
  6. Department of Cardiovascular and Thoracic Research, West Virginia University, Morgantown, WV 26506
Institutions: University of California System (United States); West Virginia University (United States)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 15, article e2516807123
Dates: received 14 July 2025; accepted 27 February 2026; published online 6 April 2026; in print 14 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2516807123 · PMID 41941629 · PMCID PMC13079983 · OpenAlex W7150834263
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), rat (organism), other condition (population), pain (population)
Keywords: addiction, therapeutic development, serotonin receptor, fentanyl, opioid
MeSH: Opioid-Related Disorders*, Receptors, Serotonin*, Analgesics, Opioid, Animals, Brain, Female, Fentanyl, Humans, Male, Rats, Rats, Sprague-Dawley (* major topic)
Journal subjects: Biological Sciences, Pharmacology
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: GATC Health (GATC); U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) (U01 DA053826, R01 DA051831, R01 DA058493); Tobacco-Related Disease Research Program (TRDRP) (T32IR4866, T34IP8023)
Citations: cited by 2 papers (Europe PMC); 43 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

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Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2516807123.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 24 authors, 5 keywords, 11 MeSH terms, 3 funders, 40 references.

Cite

This paper

Lallai, V., Kho, S., Martin, A. C., Fowler, J. P., Roach, M. L., Wang, K., Laumann, K. N., Morris, T. G., Palaniappan, M., Bautista, M., Mogul, A. S., Cheepluesak, J. E., Shrestha, B., Lade, D. M., Lagomarsino, J. E., Narayan, V., Uffens, J., Lernhardt, W., Mirzaei, S., . . . Fowler, C. D. (2026). AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder. Proceedings of the National Academy of Sciences of the United States of America, 123(15), e2516807123. https://doi.org/10.1073/pnas.2516807123

BibTeX

@article{lallai2026ai,
author = {Lallai, Valeria and Kho, Samuel and Martin, A. C. and Fowler, James P. and Roach, Madison L. and Wang, Kevin and Laumann, Kendyl N. and Morris, Tyler G. and Palaniappan, Mina and Bautista, Malia and Mogul, Allison S. and Cheepluesak, Jinjutha E. and Shrestha, Bijay and Lade, Dhanaji M. and Lagomarsino, Julia E. and Narayan, Vaishnavi and Uffens, Jayson and Lernhardt, Waldemar and Mirzaei, Saman and Jenkins, Ian and Zavala, Arturo R. and Lakey, Jonathan R. T. and Tinder, Robert and Fowler, Christie D.},
title = {{AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = apr,
volume = {123},
number = {15},
pages = {e2516807123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2516807123},
url = {https://doi.org/10.1073/pnas.2516807123},
pmid = {41941629},
pmcid = {PMC13079983}
}

RIS

TY - JOUR
AU - Lallai, Valeria
AU - Kho, Samuel
AU - Martin, A. C.
AU - Fowler, James P.
AU - Roach, Madison L.
AU - Wang, Kevin
AU - Laumann, Kendyl N.
AU - Morris, Tyler G.
AU - Palaniappan, Mina
AU - Bautista, Malia
AU - Mogul, Allison S.
AU - Cheepluesak, Jinjutha E.
AU - Shrestha, Bijay
AU - Lade, Dhanaji M.
AU - Lagomarsino, Julia E.
AU - Narayan, Vaishnavi
AU - Uffens, Jayson
AU - Lernhardt, Waldemar
AU - Mirzaei, Saman
AU - Jenkins, Ian
AU - Zavala, Arturo R.
AU - Lakey, Jonathan R. T.
AU - Tinder, Robert
AU - Fowler, Christie D.
TI - AI-derived therapeutic development of a serotonin receptor-targeting drug for the treatment of opioid use disorder
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/04/06
VL - 123
IS - 15
SP - e2516807123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2516807123
UR - https://doi.org/10.1073/pnas.2516807123
LA - en
ER -

CSL-JSON

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