A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow.

Overview

Authors: Liuruimin Xiang^1,2, Ashwini Hariharan¹, Dominic Isaacs¹, Nick Weir¹, Thomas A Longden¹

ORCID iDs: Liuruimin Xiang, Thomas A Longden

Department of Pharmacology and Physiology, University of Maryland School of Medicine, Baltimore, MD 21201
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201

Institutions: University of Maryland, Baltimore (United States)

Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 24, article e2523612123

Dates: received 29 August 2025; accepted 24 April 2026; published online 8 June 2026; in print 16 June 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1073/pnas.2523612123 · PMID 42258716 · PMCID PMC13273291 · OpenAlex W7163922940

Open access: hybrid, a free copy (OpenAlex)

Status: data only

Categories: mouse (organism), stroke (population), cellular / molecular (subfield)

Keywords: TMEM16A, pericytes, capillaries, cerebral blood flow, Ano1

MeSH: Capillaries*, Cerebrovascular Circulation*, Chlorides*, Pericytes*, Animals, Anoctamin-1, Calcium, Calcium Signaling, Chloride Channels, Endoplasmic Reticulum, Endothelial Cells, Inositol 1,4,5-Trisphosphate Receptors, Mice, Myocytes, Smooth Muscle, Ryanodine Receptor Calcium Release Channel (* major topic)

Topic: Barrier Structure and Function Studies (Neurology, Neuroscience), according to OpenAlex

Funding: HHS | NIH | National Institute of Neurological Disorders and Stroke (1DP2NS121347, R21NS142439); HHS | NIH | National Institute on Aging (NIA) (1R01AG066645); HHS | NIH | National Heart, Lung, and Blood Institute (1R01NS138179); Chan Zuckerberg Initiative (CP-2-1-0000000385); NINDS NIH HHS (DP2 NS121347, R01 NS138179, R21 NS142439); NIA NIH HHS (R01 AG066645)

Citations: not cited yet (Europe PMC); 80 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Read it in the paper: doi.org/10.1073/pnas.2523612123.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 5 keywords, 15 MeSH terms, 6 funders, 80 references.

Cite

This paper

Xiang, L., Hariharan, A., Isaacs, D., Weir, N., & Longden, T. A. (2026). A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. Proceedings of the National Academy of Sciences of the United States of America, 123(24), e2523612123. https://doi.org/10.1073/pnas.2523612123

BibTeX

@article{xiang2026pericyte, author = {Xiang, Liuruimin and Hariharan, Ashwini and Isaacs, Dominic and Weir, Nick and Longden, Thomas A}, title = {{A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow}}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, year = {2026}, month = jun, volume = {123}, number = {24}, pages = {e2523612123}, publisher = {National Academy of Sciences}, issn = {0027-8424}, doi = {10.1073/pnas.2523612123}, url = {https://doi.org/10.1073/pnas.2523612123}, pmid = {42258716}, pmcid = {PMC13273291} }

RIS

TY - JOUR AU - Xiang, Liuruimin AU - Hariharan, Ashwini AU - Isaacs, Dominic AU - Weir, Nick AU - Longden, Thomas A TI - A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow T2 - Proceedings of the National Academy of Sciences of the United States of America J2 - Proc Natl Acad Sci U S A PY - 2026 DA - 2026/06/08 VL - 123 IS - 24 SP - e2523612123 SN - 0027-8424 PB - National Academy of Sciences DO - 10.1073/pnas.2523612123 UR - https://doi.org/10.1073/pnas.2523612123 LA - en ER -

CSL-JSON

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