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G-protein regulatory network governs receptor internalization dynamics.

Overview

Authors: Jacob B Rowe1, Shubhi Pandey1, Ryan A Mayer2, W Grant Ludlam1, Julia Drube3, Asuka Inoue4,5, Carsten Hoffmann3, Kirill A Martemyanov1
ORCID iDs: Jacob B Rowe, Shubhi Pandey, Ryan A Mayer, W Grant Ludlam, Julia Drube, Asuka Inoue, Carsten Hoffmann, Kirill A Martemyanov
  1. Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL 33136
  2. Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL 33458
  3. Institute for Molecular Cell Biology, Center for Molecular Biomedicine, Universitätsklinikum Jena, Friedrich-Schiller-Universität Jena, Jena 07745, Germany
  4. Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980-8578, Japan
  5. Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan
Institutions: University of Miami (United States); University of Florida (United States); The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology; Jena University Hospital (Germany); Friedrich Schiller University Jena (Germany); Tohoku University (Japan); Kyoto University (Japan)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 24, article e2524866123
Dates: received 8 September 2025; accepted 29 April 2026; published online 9 June 2026; in print 16 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2524866123 · PMID 42263130 · PMCID PMC13273289 · OpenAlex W7163995756
Open access: hybrid, a free copy (OpenAlex)
Status: empty repository
Categories: human (organism), cellular / molecular (subfield)
Keywords: GPCR, internalization, G proteins, GNAO1 disorder
MeSH: GTP-Binding Proteins*, Receptors, G-Protein-Coupled*, Animals, Endocytosis, Guanine Nucleotide Exchange Factors, Heterotrimeric GTP-Binding Proteins, Humans, Signal Transduction (* major topic)
Topic: Receptor Mechanisms and Signaling (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: HHS | NIH | National Institute on Drug Abuse (NIDA) (DA036596, DA063102)
Citations: cited by 1 paper (Europe PMC); 76 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

figshare 32159364

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 55 files, 0 scripts
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source:

The paper's code and data availability statement is in the Data section.

Tracing map

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  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2524866123.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 8 MeSH terms, 1 funder, 76 references.

Cite

This paper

Rowe, J. B., Pandey, S., Mayer, R. A., Ludlam, W. G., Drube, J., Inoue, A., Hoffmann, C., & Martemyanov, K. A. (2026). G-protein regulatory network governs receptor internalization dynamics. Proceedings of the National Academy of Sciences of the United States of America, 123(24), e2524866123. https://doi.org/10.1073/pnas.2524866123

BibTeX

@article{rowe2026g,
author = {Rowe, Jacob B and Pandey, Shubhi and Mayer, Ryan A and Ludlam, W Grant and Drube, Julia and Inoue, Asuka and Hoffmann, Carsten and Martemyanov, Kirill A},
title = {{G-protein regulatory network governs receptor internalization dynamics}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = jun,
volume = {123},
number = {24},
pages = {e2524866123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2524866123},
url = {https://doi.org/10.1073/pnas.2524866123},
pmid = {42263130},
pmcid = {PMC13273289}
}

RIS

TY - JOUR
AU - Rowe, Jacob B
AU - Pandey, Shubhi
AU - Mayer, Ryan A
AU - Ludlam, W Grant
AU - Drube, Julia
AU - Inoue, Asuka
AU - Hoffmann, Carsten
AU - Martemyanov, Kirill A
TI - G-protein regulatory network governs receptor internalization dynamics
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/06/09
VL - 123
IS - 24
SP - e2524866123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2524866123
UR - https://doi.org/10.1073/pnas.2524866123
LA - en
ER -

CSL-JSON

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