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Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes.

Overview

Authors: Abdulmalik Obaid1, Mina-Elraheb Hanna1, Song-Wen Huang2,3, Yu-Ting Hu2,3, Omar Jáidar4, William Nix1, Jun B Ding4,5, Nicholas A Melosh1, Yu-Wei Wu2,3,4,5,6,7,8,9,10
  1. Department of Materials Science and Engineering, Stanford University, Stanford, CA 94304
  2. Institute of Molecular Biology, Academia Sinica, Taipei 115, Taiwan
  3. Department of Life Science, College of Life Science, National Taiwan University, Taipei 106, Taiwan
  4. Department of Neurosurgery, Stanford University, Stanford, CA 94305
  5. Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305
  6. Taiwan International Graduate Program in Interdisciplinary Neuroscience, Academia Sinica, Taipei 115, Taiwan
  7. Molecular and Cell Biology Program, Taiwan International Graduate Program, Academia Sinica, Taipei 115, Taiwan
  8. Genome and Systems Biology Degree Program, College of Life Science, National Taiwan University, Taipei 106, Taiwan
  9. Graduate Institute of Life Sciences, National Defense Medical University, Taipei 115, Taiwan
  10. Neuroscience Program in Academia Sinica, Academia Sinica, Taipei 115, Taiwan
Dates: received 13 October 2025; accepted 19 February 2026; published online 26 March 2026; in print 31 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2529147123 · PMID 41886379 · PMCID PMC13037841 · OpenAlex W7140777123
Open access: hybrid, a free copy (OpenAlex)
Categories: optical imaging (calcium, voltage, 2-photon) (modality), mouse (organism), methods / tools (subfield)
Methods: Connectivity
Keywords: brain–machine interfaces, neural probe insertion mechanics, pia penetration, vascular injury, two-photon imaging
MeSH: Blood Vessels*, Brain*, Electrodes, Implanted*, Animals, Biomechanical Phenomena, Brain-Computer Interfaces, Mice, Microelectrodes (* major topic)
Topic: Neuroscience and Neural Engineering (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: National Science and Technology Council (113-2321-B-001-012, 114-2321-B-001 -005); HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) (NS014861); SU | Wu Tsai Neurosciences Institute, Stanford University (Wu Tsai Neurosciences Institute) (Seed Grant); GG gift fund (gift fund); Academia Sinica (Startup Fund)
Citations: cited by 5 papers (Europe PMC); 44 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1073/pnas.2529147123.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 8 MeSH terms, 5 funders, 39 references.

Cite

This paper

Obaid, A., Hanna, M.-E., Huang, S.-W., Hu, Y.-T., Jáidar, O., Nix, W., Ding, J. B., Melosh, N. A., & Wu, Y.-W. (2026). Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes. Proceedings of the National Academy of Sciences of the United States of America, 123(13), e2529147123. https://doi.org/10.1073/pnas.2529147123

BibTeX

@article{obaid2026ultrasensitive,
author = {Obaid, Abdulmalik and Hanna, Mina-Elraheb and Huang, Song-Wen and Hu, Yu-Ting and Jáidar, Omar and Nix, William and Ding, Jun B and Melosh, Nicholas A and Wu, Yu-Wei},
title = {{Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {13},
pages = {e2529147123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2529147123},
url = {https://doi.org/10.1073/pnas.2529147123},
pmid = {41886379},
pmcid = {PMC13037841}
}

RIS

TY - JOUR
AU - Obaid, Abdulmalik
AU - Hanna, Mina-Elraheb
AU - Huang, Song-Wen
AU - Hu, Yu-Ting
AU - Jáidar, Omar
AU - Nix, William
AU - Ding, Jun B
AU - Melosh, Nicholas A
AU - Wu, Yu-Wei
TI - Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/26
VL - 123
IS - 13
SP - e2529147123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2529147123
UR - https://doi.org/10.1073/pnas.2529147123
LA - en
ER -

CSL-JSON

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"language": "en",
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