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Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra.

Overview

Authors: Zsuzsanna E Tóth1, Mónika Baráth2, Veronika F S Pape2, Klaudia Sípos1, Adél P Boros2, Máté Durst1, Péter Várnai2,3, Gábor Sirokmány2, Miklós Geiszt2
  1. Department of Anatomy, Histology and Embryology, Semmelweis University, Faculty of Medicine, Budapest H-1094, Hungary
  2. Department of Physiology, Semmelweis University, Faculty of Medicine, Budapest H-1094, Hungary
  3. Molecular Physiology Research Group, Department of Physiology, Hungarian Research Network and Semmelweis University, Budapest H-1094, Hungary
Institutions: Semmelweis University (Hungary); Hungarian Research Network (Hungary)
Dates: received 6 November 2025; accepted 19 March 2026; published online 24 April 2026; in print 28 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2531597123 · PMID 42030153 · PMCID PMC13123846 · OpenAlex W7155497160
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), rat (organism), Parkinson's (population)
Keywords: neuromelanin, lactoperoxidase, Parkinson’s disease, hydrogen peroxide
MeSH: Lactoperoxidase*, Melanins*, Substantia Nigra*, Animals, Dopaminergic Neurons, Humans, Hydrogen Peroxide, Parkinson Disease, Rats (* major topic)
Topic: melanin and skin pigmentation (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Research, Development and Innovation Office (K146086, K143509, PD138404, NVKP_16-1-2016-0039); Ministry of Innovation and Technology of Hungary (TKP2021-EGA-24, TKP2021-EGA-25)
Citations: not cited yet (Europe PMC); 44 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Read it in the paper: doi.org/10.1073/pnas.2531597123.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 9 MeSH terms, 2 funders, 44 references.

Cite

This paper

Tóth, Z. E., Baráth, M., Pape, V. F. S., Sípos, K., Boros, A. P., Durst, M., Várnai, P., Sirokmány, G., & Geiszt, M. (2026). Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra. Proceedings of the National Academy of Sciences of the United States of America, 123(17), e2531597123. https://doi.org/10.1073/pnas.2531597123

BibTeX

@article{toth2026lactoperoxidase,
author = {Tóth, Zsuzsanna E and Baráth, Mónika and Pape, Veronika F S and Sípos, Klaudia and Boros, Adél P and Durst, Máté and Várnai, Péter and Sirokmány, Gábor and Geiszt, Miklós},
title = {{Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = apr,
volume = {123},
number = {17},
pages = {e2531597123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2531597123},
url = {https://doi.org/10.1073/pnas.2531597123},
pmid = {42030153},
pmcid = {PMC13123846}
}

RIS

TY - JOUR
AU - Tóth, Zsuzsanna E
AU - Baráth, Mónika
AU - Pape, Veronika F S
AU - Sípos, Klaudia
AU - Boros, Adél P
AU - Durst, Máté
AU - Várnai, Péter
AU - Sirokmány, Gábor
AU - Geiszt, Miklós
TI - Lactoperoxidase is a candidate for mediating neuromelanin formation in the human substantia nigra
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/04/24
VL - 123
IS - 17
SP - e2531597123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2531597123
UR - https://doi.org/10.1073/pnas.2531597123
LA - en
ER -

CSL-JSON

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"PMID": "42030153",
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