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Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification.

Overview

Authors: Yuanbing Jiang1,2, Wenyue Zheng1,2, Zengjie Xia1, Wan Wa Wong1, Lily K W Cheng1,2, Fanny C Ip1,2,3, Siu Man Choi4, Andrew L T Chan4, Ching Yu Lam5, Ka Shing Ho6, Chun Keung Shum6, Jacqueline K Y Yuen7, Yat Fung Shea7, Hok Man Wai8, Vincent C T Mok9,10, Timothy C Y Kwok10, Kin Y Mok1,2,11, Hiu Yi Wong1,2, Henrik Zetterberg2,11,12,13,14,15,16,17, Amy K Y Fu1,2,3,18, Nancy Y Ip1,2,3,18
18 affiliations
  1. Division of Life Science, State Key Laboratory of Nervous System Disorders and Daniel and Mayce Yu Molecular Neuroscience Center, The Hong Kong University of Science and Technology, Hong Kong Special Administrative Region, China
  2. InnoHK Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, China
  3. Guangdong Provincial Key Laboratory of Brain Science, Disease and Drug Development, Hong Kong University of Science and Technology Shenzhen Research Institute, Shenzhen-Hong Kong Institute of Brain Science, Shenzhen, Guangdong 518057, China
  4. Department of Medicine, Queen Elizabeth Hospital, Hospital Authority, Hong Kong Special Administrative Region, China
  5. Department of Medicine and Geriatrics Ruttonjee & Tang Shiu Kin Hospitals, Hong Kong Special Administrative Region, China
  6. Department of Medicine and Geriatrics, Tuen Mun Hospital, New Territories West Cluster, Hospital Authority, Tuen Mun, Hong Kong Special Administrative Region, China
  7. Division of Geriatrics, Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Pokfulam, Hong Kong Special Administrative Region, China
  8. Department of Medicine and Geriatrics, United Christian Hospital, Hospital Authority, Kwun Tong, Hong Kong Special Administrative Region, China
  9. Division of Neurology, Department of Medicine and Therapeutics, Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Gerald Choa Neuroscience Institute, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
  10. Division of Geriatrics, Department of Medicine and Therapeutics, Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China
  11. Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
  12. United Kingdom Dementia Research Institute, University College London, London NW1 3BT, United Kingdom
  13. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Göteborg 13 46, Sweden
  14. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-43180, Sweden
  15. Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792-2420
  16. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705
  17. Centre for Brain Research, Indian Institute of Science, Bangalore 560012, India
  18. Shenzhen Institutes of Advanced Technology-Hong Kong University of Science and Technology Joint Laboratory for Brain Science, Shenzhen, Guangdong 518055, China
Dates: received 17 December 2025; accepted 18 January 2026; published online 2 March 2026; in print 10 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2536792123 · PMID 41770931 · PMCID PMC12974465 · OpenAlex W7133200504
Open access: hybrid, a free copy (OpenAlex)
Status: empty repository
Categories: other (modality), PET / SPECT (modality), human (organism), Alzheimer's / dementia (population), clinical / translational (subfield)
Methods: Statistics, Connectivity
Keywords: Alzheimer’s disease, tau pathology, disease staging, brain-derived pTau217, blood biomarkers
MeSH: Alzheimer Disease*, Brain*, tau Proteins*, Aged, Amyloid beta-Peptides, Biomarkers, Female, Humans, Male, Phosphorylation, Positron-Emission Tomography (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: the Areas of Excellence Scheme of the University Grants Committee (AoE/M-604/16); European Partnership on Metrology co-financed by the European Union's Horizon Europe Research and Innovation Programme and the Participating States (NEuroBioStand #22HLT07); Swedish Research Council ((#2023-00356 #2022-01018 and #2019-02397); Bluefield Project, Cure Alzheimer's Fund (NA); Innovation and Technology Fund for State Key Laboratory (ITCPD/17-9); the European Union Joint Programme - Neurodegenerative Disease Research (JPND2021-00694); InnoHK initiative of the Innovation and Technology Commission of the Hong Kong Special Administrative Region Government (NA); Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862); AD Strategic Fund and the Alzheimer's Association ((#ADSF-21-831376-C #ADSF-21-831381-C #ADSF-21-831377-C and #ADSF-24-1284328-C); SIAT-HKUST Joint Laboratory for Brain Science (Joint Laboratory Funding Scheme [JLFS/M-604/24]); European Union's Horizon Europe Research and Innovation Programme (No. 101053962); National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, the UK Dementia Research Institute at UCL (UKDRI-1003); Hjärnfonden, Sweden (#FO2022-0270); Olav Thon Foundation (NA); Swedish State Support for Clinical Research (#ALFGBG-71320); Stiftelsen för Gamla Tjänarinnor (Foundation for Old Servants) (NA); Research Grants Council of Hong Kong (the Theme-Based Research Scheme [T13-605/18 W], the General Research Fund [HKUST16104624 and HKUST16102824])); Guangdong-Hong Kong Joint Laboratory for Psychiatric Disorders (2023B1212120004); Erling-Persson Family Foundation (NA); Familjen Beiglers Stiftelse (NA); Familjen Rönströms Stiftelse (NA); European Union's Horizon 2020 Research and Innovation Programme under the Marie Skłodowska-Curie grant agreement (No. 860197)
Citations: cited by 10 papers (Europe PMC); 44 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

yjiangah/BDpTau217_study

License: none: the authors keep all their rights
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Size: 0 files, 0 scripts
Software Heritage: not archived
Found in: “Data, Materials, and Software Availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers
  • 30 September 2026: the link answers

The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

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  • it says that the data are available on request
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Read it in the paper: doi.org/10.1073/pnas.2536792123.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 21 authors, 5 keywords, 11 MeSH terms, 22 funders, 40 references.

Cite

This paper

Jiang, Y., Zheng, W., Xia, Z., Wong, W. W., Cheng, L. K. W., Ip, F. C., Choi, S. M., Chan, A. L. T., Lam, C. Y., Ho, K. S., Shum, C. K., Yuen, J. K. Y., Shea, Y. F., Wai, H. M., Mok, V. C. T., Kwok, T. C. Y., Mok, K. Y., Wong, H. Y., Zetterberg, H., . . . Ip, N. Y. (2026). Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification. Proceedings of the National Academy of Sciences of the United States of America, 123(10), e2536792123. https://doi.org/10.1073/pnas.2536792123

BibTeX

@article{jiang2026head,
author = {Jiang, Yuanbing and Zheng, Wenyue and Xia, Zengjie and Wong, Wan Wa and Cheng, Lily K W and Ip, Fanny C and Choi, Siu Man and Chan, Andrew L T and Lam, Ching Yu and Ho, Ka Shing and Shum, Chun Keung and Yuen, Jacqueline K Y and Shea, Yat Fung and Wai, Hok Man and Mok, Vincent C T and Kwok, Timothy C Y and Mok, Kin Y and Wong, Hiu Yi and Zetterberg, Henrik and Fu, Amy K Y and Ip, Nancy Y},
title = {{Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {10},
pages = {e2536792123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2536792123},
url = {https://doi.org/10.1073/pnas.2536792123},
pmid = {41770931},
pmcid = {PMC12974465}
}

RIS

TY - JOUR
AU - Jiang, Yuanbing
AU - Zheng, Wenyue
AU - Xia, Zengjie
AU - Wong, Wan Wa
AU - Cheng, Lily K W
AU - Ip, Fanny C
AU - Choi, Siu Man
AU - Chan, Andrew L T
AU - Lam, Ching Yu
AU - Ho, Ka Shing
AU - Shum, Chun Keung
AU - Yuen, Jacqueline K Y
AU - Shea, Yat Fung
AU - Wai, Hok Man
AU - Mok, Vincent C T
AU - Kwok, Timothy C Y
AU - Mok, Kin Y
AU - Wong, Hiu Yi
AU - Zetterberg, Henrik
AU - Fu, Amy K Y
AU - Ip, Nancy Y
TI - Head-to-head comparison of brain-derived pTau217 and total pTau217 for brain amyloid and tau pathology classification
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/02
VL - 123
IS - 10
SP - e2536792123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2536792123
UR - https://doi.org/10.1073/pnas.2536792123
LA - en
ER -

CSL-JSON

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