OSCR

Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection.

Overview

Authors: Hana Janova1,2, Fang R Zhao1, Ali Akgul1, Meredith Schatz1, Daniel M Alligood3, David M Alvarado3, Larissa B Thackray1, Thaddeus S Stappenbeck4, Michael S Diamond1,5,6,7
ORCID iDs: Fang R Zhao, David M Alvarado, Thaddeus S Stappenbeck, Michael S Diamond
  1. Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110
  2. Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030
  3. Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110
  4. Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, OH 44195
  5. Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110
  6. Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110
  7. The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110
Institutions: Washington University in St. Louis (United States); The University of Texas Health Science Center at Houston (United States); Cleveland Clinic (United States)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 11, article e2537058123
Dates: received 22 December 2025; accepted 4 February 2026; published online 10 March 2026; in print 17 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2537058123 · PMID 41805580 · PMCID PMC12993982 · OpenAlex W7134958529
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials
Keywords: pathogenesis, gastrointestinal, neuron, macrophage, glia
MeSH: Enteric Nervous System*, Macrophages*, Neuroglia*, Neurons*, West Nile Fever*, West Nile virus*, Animals, Inflammation, Mice, Mice, Inbred C57BL (* major topic)
Topic: Congenital gastrointestinal and neural anomalies (Surgery, Medicine), according to OpenAlex
Funding: HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK122790, T32 DK077653); NIDDK NIH HHS (R01 DK122790, T32 DK077653); NIAMS NIH HHS (K08 AR084597); HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (K08 AR084597)
Citations: cited by 2 papers (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2537058123.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 10 MeSH terms, 4 funders, 47 references.

Cite

This paper

Janova, H., Zhao, F. R., Akgul, A., Schatz, M., Alligood, D. M., Alvarado, D. M., Thackray, L. B., Stappenbeck, T. S., & Diamond, M. S. (2026). Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection. Proceedings of the National Academy of Sciences of the United States of America, 123(11), e2537058123. https://doi.org/10.1073/pnas.2537058123

BibTeX

@article{janova2026macrophage,
author = {Janova, Hana and Zhao, Fang R and Akgul, Ali and Schatz, Meredith and Alligood, Daniel M and Alvarado, David M and Thackray, Larissa B and Stappenbeck, Thaddeus S and Diamond, Michael S},
title = {{Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {11},
pages = {e2537058123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2537058123},
url = {https://doi.org/10.1073/pnas.2537058123},
pmid = {41805580},
pmcid = {PMC12993982}
}

RIS

TY - JOUR
AU - Janova, Hana
AU - Zhao, Fang R
AU - Akgul, Ali
AU - Schatz, Meredith
AU - Alligood, Daniel M
AU - Alvarado, David M
AU - Thackray, Larissa B
AU - Stappenbeck, Thaddeus S
AU - Diamond, Michael S
TI - Macrophage-glia interactions regulate immune damage to enteric neurons during West Nile virus infection
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/10
VL - 123
IS - 11
SP - e2537058123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2537058123
UR - https://doi.org/10.1073/pnas.2537058123
LA - en
ER -

CSL-JSON

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"family": "Janova",
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