OSCR

An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2.

Overview

Authors: Dalton J Huey1, Eduardo Guadarrama1, Jean-Marc DeKeyser1, Carlos G Vanoye1, Christine Q Simmons1, Qianru Li1, Emily K Stroup1, Zhe Ji1, Alfred L George Jr1
  1. Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
Institutions: Northwestern University (United States)
Dates: received 25 March 2026; accepted 24 July 2026; published online 18 August 2026; in print 25 August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2610782123 · PMID 42611988 · PMCID PMC13506078 · OpenAlex W7141198329
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Spectral & time-frequency, Statistics, Evoked potentials
Keywords: uORF, 5’-UTR, epilepsy, KV7.2, base editing
MeSH: KCNQ2 Potassium Channel*, Neurons*, Open Reading Frames*, Protein Biosynthesis*, 5' Untranslated Regions, Animals, Codon, Initiator, HEK293 Cells, Humans, Mutation (* major topic)
Topic: RNA and protein synthesis mechanisms (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: NINDS NIH HHS (F31 NS135753, R01 NS137587); NIH HHS (S10 OD034362); NIGMS NIH HHS (R35 GM138192, T32 GM105538); American Heart Association (AHA) (26POST1542927); HHS | NIH (NIH) (GM105538, NS135753, OD034362, GM138192, NS137587, HL161389); NHLBI NIH HHS (R01 HL161389)
Citations: cited by 1 paper (Europe PMC); 78 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI

Read it in the paper: doi.org/10.1073/pnas.2610782123.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 10 MeSH terms, 6 funders, 75 references.

Cite

This paper

Huey, D. J., Guadarrama, E., DeKeyser, J.-M., Vanoye, C. G., Simmons, C. Q., Li, Q., Stroup, E. K., Ji, Z., & George, A. L. (2026). An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2. Proceedings of the National Academy of Sciences of the United States of America, 123(34), e2610782123. https://doi.org/10.1073/pnas.2610782123

BibTeX

@article{huey2026upstream,
author = {Huey, Dalton J and Guadarrama, Eduardo and DeKeyser, Jean-Marc and Vanoye, Carlos G and Simmons, Christine Q and Li, Qianru and Stroup, Emily K and Ji, Zhe and George, Alfred L},
title = {{An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = aug,
volume = {123},
number = {34},
pages = {e2610782123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2610782123},
url = {https://doi.org/10.1073/pnas.2610782123},
pmid = {42611988},
pmcid = {PMC13506078}
}

RIS

TY - JOUR
AU - Huey, Dalton J
AU - Guadarrama, Eduardo
AU - DeKeyser, Jean-Marc
AU - Vanoye, Carlos G
AU - Simmons, Christine Q
AU - Li, Qianru
AU - Stroup, Emily K
AU - Ji, Zhe
AU - George, Alfred L
TI - An upstream open reading frame represses translation of the neuronal potassium channel KCNQ2
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/08/18
VL - 123
IS - 34
SP - e2610782123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2610782123
UR - https://doi.org/10.1073/pnas.2610782123
LA - en
ER -

CSL-JSON

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