MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.

1. Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento 38123, Italy
2. ‘Rita Levi Montalcini’ Department of Neuroscience, ALS Centre, University of Turin, Turin 10126, Italy
3. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
4. Department CIBIO, Advanced Imaging Core Facility (AICF), University of Trento, Trento 38123, Italy
5. Department Medical Biotechnology and Translational Medicine, Università degli Studi di Milano, Milan 20122, Italy
6. Sheffield Institute for Translational Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield S10 2HQ, UK
7. Department of Pharmacy, Pharmacology and Toxicology Unit, University of Genoa, Genoa 16132, Italy
8. International Centre for Genetic Engineering and Biotechnology, Trieste 34149, Italy
9. Department CIBIO, Proteomics and Mass Spectrometry Core Facility (MS), University of Trento, Trento 38123, Italy
10. Department CIBIO, High Throughput Screening and Validation Core Facility (HTS), University of Trento, Trento 38123, Italy
11. Research Center for ALS, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan 20156, Italy
12. Department of Life Sciences, University of Trieste, Trieste 34127, Italy
13. Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena 41125, Italy
14. Department of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste 34136, Italy
15. Department CIBIO, Model Organism Core Facility (MOF), University of Trento, Trento 38123, Italy
16. Department CIBIO, Next Generation Sequencing Core Facility (NGS), University of Trento, Trento 38123, Italy
17. Department of Biological Sciences, Lebanese American University, PO Box 36, Byblos, Lebanon
18. Vall d’Hebron Institute of Oncology, Cellex Centre, Hospital University Vall d’Hebron Campus, Barcelona 08035, Spain
19. Institució Catalana de Recerca i Estudis Avançats, Barcelona 08010, Spain
20. Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra 08193, Spain
21. Peptomyc S.L., Barcelona 08035, Spain
22. CNR Unit Trento, Institute of Biophysics, Trento 38123, Italy
23. IRCCS Ospedale Policlinico San Martino, Genoa 16132, Italy
24. Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20145, Italy
25. Department of Pathophysiology and Transplantation (DEPT), Dino Ferrari Center, Università degli Studi di Milano, Milan 20122, Italy
26. Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino, SC Neurologia 1U, Turin 10126, Italy
27. The NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK
28. Molecular Neuroscience Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan
29. Department of Biomedical Sciences (DBS), University of Padova, Padova 35131, Italy
30. Veneto Institute of Molecular Medicine (VIMM), Padova 35129, Italy

@article{fioretti2026myc,
author = {Fioretti, Paolo V and Barbieri, Anna and Migazzi, Alice and Bressan, Davide and Grassano, Maurizio and Donini, Luisa and Roccuzzo, Michela and Torrieri, Maria Claudia and Conci, Francesca and Ferracci, Elisa and Invernizzi, Sabrina and Bowden, Katie M and Bacchetti, Francesca and Cappelli, Sara and Peroni, Daniele and Belli, Romina and Pancher, Michael and Mugoni, Vera and Scarduelli, Giorgina and Gianesello, Matteo and Pasetto, Laura and Canarutto, Giulia and Carra, Serena and Soldano, Alessia and Bisio, Alessandra and Robbiati, Sergio and Valentini, Chiara and Nardella, Caterina and Piazza, Silvano and D’Agostino, Vito G and Quattrone, Alessandro and Sleiman, Sama and Whitfield, Jonathan R and Soucek, Laura and Vignoli, Beatrice and Viero, Gabriella and Tiberi, Luca and Zippo, Alessio and Demichelis, Francesca and Bonetto, Valentina and Milanese, Marco and Buratti, Emanuele and Verde, Federico and Ticozzi, Nicola and Calvo, Andrea and Ratti, Antonia and Shaw, Pamela J and Terenzio, Marco and Chiacchiera, Fulvio and Pennuto, Maria and Basso, Manuela},
title = {{MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis}},
journal = {Brain : a journal of neurology},
year = {2026},
month = may,
volume = {149},
number = {5},
pages = {1604--1622},
publisher = {Oxford University Press},
issn = {0006-8950},
doi = {10.1093/brain/awaf360},
url = {https://doi.org/10.1093/brain/awaf360},
pmid = {41004427},
pmcid = {PMC13270318}
}

TY - JOUR
AU - Fioretti, Paolo V
AU - Barbieri, Anna
AU - Migazzi, Alice
AU - Bressan, Davide
AU - Grassano, Maurizio
AU - Donini, Luisa
AU - Roccuzzo, Michela
AU - Torrieri, Maria Claudia
AU - Conci, Francesca
AU - Ferracci, Elisa
AU - Invernizzi, Sabrina
AU - Bowden, Katie M
AU - Bacchetti, Francesca
AU - Cappelli, Sara
AU - Peroni, Daniele
AU - Belli, Romina
AU - Pancher, Michael
AU - Mugoni, Vera
AU - Scarduelli, Giorgina
AU - Gianesello, Matteo
AU - Pasetto, Laura
AU - Canarutto, Giulia
AU - Carra, Serena
AU - Soldano, Alessia
AU - Bisio, Alessandra
AU - Robbiati, Sergio
AU - Valentini, Chiara
AU - Nardella, Caterina
AU - Piazza, Silvano
AU - D’Agostino, Vito G
AU - Quattrone, Alessandro
AU - Sleiman, Sama
AU - Whitfield, Jonathan R
AU - Soucek, Laura
AU - Vignoli, Beatrice
AU - Viero, Gabriella
AU - Tiberi, Luca
AU - Zippo, Alessio
AU - Demichelis, Francesca
AU - Bonetto, Valentina
AU - Milanese, Marco
AU - Buratti, Emanuele
AU - Verde, Federico
AU - Ticozzi, Nicola
AU - Calvo, Andrea
AU - Ratti, Antonia
AU - Shaw, Pamela J
AU - Terenzio, Marco
AU - Chiacchiera, Fulvio
AU - Pennuto, Maria
AU - Basso, Manuela
TI - MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis
T2 - Brain : a journal of neurology
J2 - Brain
PY - 2026
DA - 2026/05/01
VL - 149
IS - 5
SP - 1604
EP - 1622
SN - 0006-8950
PB - Oxford University Press
DO - 10.1093/brain/awaf360
UR - https://doi.org/10.1093/brain/awaf360
LA - en
ER -

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