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Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy.

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Paper

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The authors' code

MATLAB · 30 lines · 1.1 KB · no license

  1. function ExportScoutsToMri_new(sMri, sScouts, GridLoc)
  2. % Copyright (c) 2024 Margherita A. G. Matarrese
  3. % This function get selected scouts, convert the BEM grid, in which the
  4. % scouts are build, to MRI coordinates, and in a loop on all the scouts
  5. % to export, get vertices coordinates, extract envelope, compute
  6. % interpolation matrix from tessellation to MRI voxel grid, compute
  7. % scout mask and in the end save new MRI file
  9. GridLoc = cs_convert(sMri, 'scs', 'voxel', GridLoc);
  11. sMri.Cube = 0 * sMri.Cube(:,:,:,1);
  12. for i = 1:length(sScouts)
  13. Vertices = GridLoc(sScouts(i).Vertices,:);
  14. if exist('alphaShape', 'file') && exist('boundary', 'file')
  15. Faces = boundary(Vertices, 0.7);
  16. else
  17. Faces = convhulln(Vertices);
  18. end
  19. tess2mri_interp = tess_tri_interp(Vertices, Faces, size(sMri.Cube));
  20. scoutMask = tess_mrimask(size(sMri.Cube), tess2mri_interp);
  21. maskValue = round(str2num(sScouts(i).Label));
  22. if isempty(maskValue)
  23. maskValue = i;
  24. end
  26. sMri.Cube(scoutMask) = maskValue;
  27. end
  29. export_mri(sMri);
  30. end

ExportScoutsToMri_new.m at commit 3b3360e, no license · at the source

Overview

Authors: Sadra Shahdadian1,2, Yanlong Song3, Alireza Vaysi1,2, Setu Shiroya4, Haden Ray5, Margherita A G Matarrese1,6, Madhan Bosemani1, Fernando Acosta1, Brooke Kimbrell1, Warren Marks1,7, Christos Papadelis1,2,4
ORCID iDs: Sadra Shahdadian, Margherita A G Matarrese, Christos Papadelis
  1. Neuroscience Research, Jane and John Justin Institute for Mind Health, Cook Children's Health Care System, Fort Worth, TX 76104, USA
  2. Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76010, USA
  3. Departments of Physical Medicine and Rehabilitation and Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
  4. Burnett School of Medicine, Texas Christian University, Fort Worth, TX 76129, USA
  5. Department of Kinesiology, Texas Christian University, Fort Worth, TX 76109, USA
  6. Department of Engineering, Università Campus Bio-Medico di Roma, Rome 00128, Italy
  7. Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Institutions: The University of Texas at Arlington (United States); Cook Children's Medical Center (United States); Cook Children's Health Care System (United States); The University of Texas Southwestern Medical Center (United States); Texas Christian University (United States); Università Campus Bio-Medico (Italy); University of North Texas Health Science Center (United States)
Journal: Brain communications, volume 8, issue 3, article fcag185
Dates: received 22 August 2025; accepted 20 May 2026; published online 21 May 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1093/braincomms/fcag185 · PMID 42516611 · PMCID PMC13403283 · OpenAlex W7162012528
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: structural MRI / diffusion (modality), human (organism), other condition (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Preprocessing, Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Connectivity, fMRI & imaging, Physiology & signal measures
Keywords: hemiplegic cerebral palsy, neuroplasticity, electromagnetic source imaging, diffusion MRI
Topic: Cerebral Palsy and Movement Disorders (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (R218D090549-2); Principal Investigator
Citations: not cited yet (Europe PMC); 73 references in the paper

Abstract

Children with hemiplegic cerebral palsy exhibit diverse sensory deficits linked to varied atypical brain reorganization patterns. The underlying mechanisms of these patterns remain poorly understood. Using multimodal neuroimaging, we associate functional and structural neuroplasticity in the somatosensory system of children with hemiplegic cerebral palsy with lesion type and behavioural outcome. We hypothesize that different lesion types produce distinct patterns of neuroplasticity, which correlate with varying levels of sensory and motor behavioural deficits. We examined 22 children with hemiplegic cerebral palsy (7 with cortical-subcortical, 12 with periventricular, and 3 with other lesions) and 24 age-matched neurotypical controls. We assessed the somatosensory outcomes through touch sensitivity and two-point discrimination measures, and motor outcomes through movement range, accuracy, dexterity, and fluency measures. We quantified the integrity of ascending sensory and somatosensory commissural fibres with diffusion-weighted MRI and measured cortical responses to haptic stimulation with magnetoencephalography and high-density EEG. Children with cortical-subcortical lesions demonstrated higher sensory thresholds and worse movement quality in the paretic hand compared to the periventricular lesion (P < 0.05) and control group (P < 0.01). Functional imaging revealed suppressed primary and secondary somatosensory cortical activations (P < 0.01) and prolonged primary somatosensory cortex latency (P < 0.05) in the more affected hemisphere in response to paretic hand stimulation. These children also exhibited more pronounced disruption of interhemispheric functional balance (P < 0.05). Tractography showed greater microstructural damage—increased mean (P < 0.01), axial (P < 0.01), and radial (P < 0.01) diffusivities—in both ascending sensory and commissural fibres in the more affected hemisphere of the cortical-subcortical lesion group. In contrast, the periventricular lesion group showed unilateral damage to ascending sensory fibres (P < 0.01) and bilateral damage to commissural fibres (P < 0.05). More severe diffusion abnormalities were associated with lower cortical amplitudes (Rho = −0.58 to –0.78, P < 0.05), delayed latencies (Rho = 0.69, P < 0.05), and decreased lateralization (Rho = −0.62 to −0.72, P < 0.05). Moderate to strong correlations were observed between cortical amplitudes and touch sensitivity (Rho = −0.56 to −0.60, P < 0.05) and discriminability (Rho = –0.77, P < 0.01). Our findings show that children with hemiplegic cerebral palsy exhibit distinct structural and functional neuroplasticity patterns based on lesion type. Cortical-subcortical lesions lead to more extensive somatosensory damage, while periventricular lesions are linked to greater neuroplastic potential. These insights deepen our understanding of neuroplasticity mechanisms and highlight targets for optimizing therapeutic interventions.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above.

shsadra/Brain-Communications-2025

License: none: the authors keep all their rights
State: the link answers, verified on 28 September 2026
Evidence: files inventoried
Commit: 3b3360ee49151001d1a13cdb1e67c784818ad9ef, 18 December 2025
Languages: MATLAB (2)
Size: 2 files, 2 scripts
Software Heritage: not archived
Found in: “Data availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 28 September 2026: the link answers
  • 28 September 2026: the link answers
2 files
At the source: github.com/shsadra/Brain-Communications-2025.git

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 2 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data availability

The data are available from the corresponding author upon request. The code is available on GitHub (https://github.com/shsadra/Brain-Communications-2025.git).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 4 keywords, 2 funders, 71 references.

Cite

This paper

Shahdadian, S., Song, Y., Vaysi, A., Shiroya, S., Ray, H., Matarrese, M. A. G., Bosemani, M., Acosta, F., Kimbrell, B., Marks, W., & Papadelis, C. (2026). Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy. Brain communications, 8(3), fcag185. https://doi.org/10.1093/braincomms/fcag185

BibTeX

@article{shahdadian2026functional,
author = {Shahdadian, Sadra and Song, Yanlong and Vaysi, Alireza and Shiroya, Setu and Ray, Haden and Matarrese, Margherita A G and Bosemani, Madhan and Acosta, Fernando and Kimbrell, Brooke and Marks, Warren and Papadelis, Christos},
title = {{Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy}},
journal = {Brain communications},
year = {2026},
month = may,
volume = {8},
number = {3},
pages = {fcag185},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/braincomms/fcag185},
url = {https://doi.org/10.1093/braincomms/fcag185},
pmid = {42516611},
pmcid = {PMC13403283}
}

RIS

TY - JOUR
AU - Shahdadian, Sadra
AU - Song, Yanlong
AU - Vaysi, Alireza
AU - Shiroya, Setu
AU - Ray, Haden
AU - Matarrese, Margherita A G
AU - Bosemani, Madhan
AU - Acosta, Fernando
AU - Kimbrell, Brooke
AU - Marks, Warren
AU - Papadelis, Christos
TI - Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/05/21
VL - 8
IS - 3
SP - fcag185
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/braincomms/fcag185
UR - https://doi.org/10.1093/braincomms/fcag185
LA - en
ER -

CSL-JSON

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"id": "10.1093/braincomms/fcag185",
"type": "article-journal",
"title": "Functional and structural neuroplasticity of somatosensory system in hemiplegic cerebral palsy",
"container-title": "Brain communications",
"author": [
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"family": "Shahdadian",
"given": "Sadra"
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"family": "Song",
"given": "Yanlong"
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{
"family": "Vaysi",
"given": "Alireza"
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{
"family": "Shiroya",
"given": "Setu"
},
{
"family": "Ray",
"given": "Haden"
},
{
"family": "Matarrese",
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{
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"given": "Madhan"
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{
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"given": "Fernando"
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{
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],
"container-title-short": "Brain Commun",
"volume": "8",
"issue": "3",
"page": "fcag185",
"DOI": "10.1093/braincomms/fcag185",
"PMID": "42516611",
"PMCID": "PMC13403283",
"ISSN": "2632-1297",
"publisher": "Oxford University Press",
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"language": "en",
"issued": {
"date-parts": [
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