Thalamocortical seizure onset patterns in drug-resistant focal epilepsy.
The 1 match
- [1] § Results › Patient and seizure characteristics ↔ get_amps5.m, lines 121–142 · score 0.73 · Grand av, sEEG1, voltage amplitude, S2L, S2R, RMS
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The authors' code
MATLAB · 165 lines · 4 KB · no license · 1 match
get_amps5.m at commit 0cf18ff, no license · at the source
Overview
- Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
- Department of Neurology, The Alfred Hospital, Melbourne, VIC 3004, Australia
- Department of Neuroscience, Monash University, Melbourne, VIC 3004, Australia
- Czech Institute of Informatics, Robotics, and Cybernetics, Czech Technical University in Prague, Prague 16000, Czech Republic
- Department of Natural Sciences, Faculty of Biomedical Engineering, Czech Technical University in Prague, Kladno 27201, Czech Republic
- Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA
Abstract
Drug-resistant epilepsy affects tens of millions of people worldwide and is associated with considerable morbidity and mortality. Thalamic deep brain stimulation and cortical responsive neurostimulation are proven treatments for focal epilepsy. Both have been used to target a range of thalamic nuclei; yet, the roles of these thalamic nuclei in focal seizure generation remain incompletely understood. Thirteen patients with drug-resistant focal epilepsy undergoing intracranial EEG were consented to undergo investigation of thalamocortical networks. Sampled regions included cortical, mesial temporal, and thalamic brain regions. Visual and spectral analyses were performed to identify seizure onset patterns and correlate thalamic and cortical seizure activity. Thalamic ictal discharges were observed in 89% of seizures. Of these, 56% demonstrated synchronous thalamocortical activity with distinct patterns. These onset patterns included hypersynchronous spiking, low-voltage fast activity, ictal baseline shifts, and broadband suppression. Multiple thalamic nuclei were involved in ictal organization and propagation, with the specific nuclei depending on the cortical seizure network. The thalamus plays a crucial role in focal onset seizure generation and propagation, with distinct seizure onset patterns and nuclei involved. These findings support exploring a broader range of thalamic nuclei in epilepsy neurostimulation and have implications for seizure detection settings in intracranial sensing devices.
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hdsimpson/tsr-analysis-2026
0cf18ff7914c69a1365d96d5cd76096ba9f4902c, 9 March 2026Availability: 1 check, the latest on 27 September 2026: the link answers
- 27 September 2026: the link answers
7 files, not copied: shown from their source
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- analyse_RCS2.m — MATLAB, 306 lines, shown from its source
- extract_analyse_IRB2.m — MATLAB, 318 lines, shown from its source
- get_amps5.m — MATLAB, 165 lines, 1 match, shown from its source
- get_delays_by_subj2.m — MATLAB, 51 lines, shown from its source
- plot_sz_data5.m — MATLAB, 99 lines, shown from its source
- pre_process_EEG2.m — MATLAB, 30 lines, shown from its source
- pre_process_EEG3.m — MATLAB, 37 lines, shown from its source
The paper's code and data availability statement is in the Data section.
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Data
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Data availability
The source data for the results presented in this manuscript are available from the authors on reasonable request. Code used to analyse and visualize the data is available at: https://
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 3 funders, 30 references.
Cite
This paper
Simpson, H. D., Kremen, V., Sladky, V., Brinkmann, B. H., Gregg, N. M., Lundstrom, B. N., Miller, K. J., Van Gompel, J. J., & Worrell, G. A. (2026). Thalamocortical seizure onset patterns in drug-resistant focal epilepsy. Brain communications, 8(4), fcag227. https://
BibTeX
@article{simpson2026thal
author = {Simpson, Hugh D and Kremen, Vaclav and Sladky, Vladimir and Brinkmann, Benjamin H and Gregg, Nicholas M and Lundstrom, Brian N and Miller, Kai J and Van Gompel, Jamie J and Worrell, Gregory A},
title = {{Thalamocortical seizure onset patterns in drug-resistant focal epilepsy}},
journal = {Brain communications},
year = {2026},
month = jun,
volume = {8},
number = {4},
pages = {fcag227},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/
url = {https://
pmid = {42396599},
pmcid = {PMC13326942}
}
RIS
TY - JOUR
AU - Simpson, Hugh D
AU - Kremen, Vaclav
AU - Sladky, Vladimir
AU - Brinkmann, Benjamin H
AU - Gregg, Nicholas M
AU - Lundstrom, Brian N
AU - Miller, Kai J
AU - Van Gompel, Jamie J
AU - Worrell, Gregory A
TI - Thalamocortical seizure onset patterns in drug-resistant focal epilepsy
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/
VL - 8
IS - 4
SP - fcag227
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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