Assessment of molecular tools in pediatric, adolescent, and young adult meningioma highlights the need for lifespan precision in neuro-oncology.
Overview
and 13 other authors
Jill S Barnholtz-Sloan11,12, Andrew E Sloan13, Silky Chotai14, Lola B Chambless14, Alireza Mansouri15, Sameer Agnihotri16, Serge Makarenko17, Stephen Yip17, Derek S Tsang18, Kenneth Aldape19, Andrew Gao20, Farshad Nassiri1,3,4, Gelareh Zadeh1,2,3,420 affiliations
- Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada (L.S.Y., A.P.L., J.Z.W., C.G., A.A., Y.E., F.N., G.Z.)
- Department of Neurologic Surgery, Mayo Clinic, Rochester, MN, USA (L.S.Y., O.S., G.Z.)
- Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada (L.S.Y., A.P.L., J.Z.W., J.L., V.P., C.G., A.A., Y.E., R.Y., R.K, P.P., Q.W., S.M., S.B., F.N, G.Z.)
- MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada (L.S.Y., A.P.L., J.Z.W., J.L., V.P., C.G., A.A., Y.E., Y.M., R.Y., R.K, P.P., Q.W., S.M., S.B., F.N, G.Z.)
- Department of Engineering, Thompson Rivers University, Kamloops, BC, Canada (Y.M.)
- Department of Neurological Surgery, Keck School of Medicine, USC, Los Angeles, CA, USA (A.A.C.-G.)
- Department of Neurology and Interdisciplinary Neuro-Oncology, Center for Neuro-Oncology, Comprehensive Cancer Center, Hertie Institute for Clinical Brain Research, Eberhard Karls University Tübingen, Tübingen, Germany (G.T.)
- Cluster of Excellence (EXC 2180) “Image Guided and Functionally Instructed Tumor Therapies,”, Eberhard Karls University Tübingen, Tübingen, Germany (G.T.)
- German Cancer Consortium (DKTK), Partner Site Tübingen, a Partnership Between DKFZ and Tübingen University Hospital, Tübingen, Germany (G.T.)
- Department of Neurosurgery, Center for Neuro-Oncology, Comprehensive Cancer Center, Eberhard Karls University Tübingen, Tübingen, Germany (M.T., F.B.)
- Center for Biomedical Informatics & Information Technology (CBIIT), National Cancer Institute, Bethesda, MD, USA (J.S.B.-S.)
- Trans Divisional Research Program (TDRP), Division of Cancer Epidemiology and Genetics (DCEG), National Cancer Institute, Bethesda, MD, USA (J.S.B.-S.)
- Department of Neurological Surgery & Piedmont, Brain Tumor Center, Atlanta, GA, USA (A.E.S.)
- Department of Neurosurgery, Vanderbilt University Medical Center, Nashville, TN, USA (S.C., L.B.C.)
- Department of Neurosurgery, Penn State Milton S. Hershey Medical Center, Hershey, PA, USA (A.M.)
- Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA (S.A.)
- Division of Neurosurgery, University of British Columbia, Vancouver, BC, Canada (S.M., S.Y.)
- Radiation Medicine Program, Princess Margaret Cancer Centre, Toronto, ON, Canada (D.S.T.)
- Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA (K.A.)
- Division of Laboratory Medicine and Pathobiology, University Health Network, Toronto, ON, Canada (A.G.)
Abstract
Background: Adolescent and young adult (AYA) patients remain underrepresented in neuro-oncology research. Despite being the second most common primary brain tumor in this population, meningiomas have not been studied using age-specific molecular analyses. DNA methylation-based classification and prognostic tools have transformed meningioma care. This study aimed to evaluate the performance of these tools across age groups.
Methods: We analyzed 1,568 meningiomas with DNA methylation and clinical data, including 18 pediatric patients (<15 years), 195 AYA patients (15-39 years), and 1,355 adult patients (>39 years). Pediatric and AYA (P/
Results: While histologic grading was comparable between cohorts, P/
Conclusions: Molecular tools developed in adult-dominant cohorts do not generalize to younger patients due to both biological divergence and exclusion from model development. These findings underscore the need for age-specific molecular frameworks and highlight the imperative of including P/
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
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Data
Datasets cited
- geo:GSE136661, at NCBI GEO; found in the text, “Patient Cohort and Data Sources”
Data Availability
Data and source code will be made available on Zenodo at time of publication.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 33 authors, 5 keywords, 16 MeSH terms, 1 funder, 34 references.
Cite
This paper
Yefet, L. S., Landry, A. P., Wang, J. Z., Liu, J., Patil, V., Gui, C., Ajisebutu, A., Ellenbogen, Y., Mamatjan, Y., Yakubov, R., Kaloti, R., Persaud, P., Wei, Q., Singh, O., Mansouri, S., Bunda, S., Cohen-Gadol, A. A., Tabatabai, G., Tatagiba, M., . . . Zadeh, G. (2026). Assessment of molecular tools in pediatric, adolescent, and young adult meningioma highlights the need for lifespan precision in neuro-oncology. Neuro-oncology, 28(3), 765-775. https://
BibTeX
@article{yefet2026assess
author = {Yefet, Leeor S and Landry, Alexander P and Wang, Justin Z and Liu, Jeff and Patil, Vikas and Gui, Chloe and Ajisebutu, Andrew and Ellenbogen, Yosef and Mamatjan, Yasin and Yakubov, Rebecca and Kaloti, Ramneet and Persaud, Phooja and Wei, Qingxia and Singh, Olivia and Mansouri, Sheila and Bunda, Severa and Cohen-Gadol, Aaron A and Tabatabai, Ghazaleh and Tatagiba, Marcos and Behling, Felix and Barnholtz-Sloan, Jill S and Sloan, Andrew E and Chotai, Silky and Chambless, Lola B and Mansouri, Alireza and Agnihotri, Sameer and Makarenko, Serge and Yip, Stephen and Tsang, Derek S and Aldape, Kenneth and Gao, Andrew and Nassiri, Farshad and Zadeh, Gelareh},
title = {{Assessment of molecular tools in pediatric, adolescent, and young adult meningioma highlights the need for lifespan precision in neuro-oncology}},
journal = {Neuro-oncology},
year = {2026},
month = mar,
volume = {28},
number = {3},
pages = {765--775},
publisher = {Oxford University Press},
issn = {1522-8517},
doi = {10.1093/
url = {https://
pmid = {41206747},
pmcid = {PMC13070492}
}
RIS
TY - JOUR
AU - Yefet, Leeor S
AU - Landry, Alexander P
AU - Wang, Justin Z
AU - Liu, Jeff
AU - Patil, Vikas
AU - Gui, Chloe
AU - Ajisebutu, Andrew
AU - Ellenbogen, Yosef
AU - Mamatjan, Yasin
AU - Yakubov, Rebecca
AU - Kaloti, Ramneet
AU - Persaud, Phooja
AU - Wei, Qingxia
AU - Singh, Olivia
AU - Mansouri, Sheila
AU - Bunda, Severa
AU - Cohen-Gadol, Aaron A
AU - Tabatabai, Ghazaleh
AU - Tatagiba, Marcos
AU - Behling, Felix
AU - Barnholtz-Sloan, Jill S
AU - Sloan, Andrew E
AU - Chotai, Silky
AU - Chambless, Lola B
AU - Mansouri, Alireza
AU - Agnihotri, Sameer
AU - Makarenko, Serge
AU - Yip, Stephen
AU - Tsang, Derek S
AU - Aldape, Kenneth
AU - Gao, Andrew
AU - Nassiri, Farshad
AU - Zadeh, Gelareh
TI - Assessment of molecular tools in pediatric, adolescent, and young adult meningioma highlights the need for lifespan precision in neuro-oncology
T2 - Neuro-oncology
J2 - Neuro Oncol
PY - 2026
DA - 2026/
VL - 28
IS - 3
SP - 765
EP - 775
SN - 1522-8517
PB - Oxford University Press
DO - 10.1093/
UR - https://
LA - en
ER -
CSL-JSON
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