OSCR

Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity.

Overview

Authors: Louisa A K Zolkiewski1, Kimberly L Rockley1, Ruth A Roberts1,2, Hannah G Jennings1, Magali-Anne Maizières1, Karen Jones1, James L McDonagh1, Katie Newman1, Ed J Griffen3, Jessica E Stacey3, Michael J Morton1
ORCID iDs: Louisa A K Zolkiewski, Ruth A Roberts
  1. ApconiX, Macclesfield SK10 4TG, United Kingdom
  2. Department of Biosciences, University of Birmingham, Edgbaston B15 1TT, United Kingdom
  3. MedChemica Consultancy Ltd, Motorworks, Macclesfield, Cheshire SK11 6DU, United Kingdom
Institutions: University of Birmingham (United Kingdom)
Journal: Toxicological sciences : an official journal of the Society of Toxicology, volume 209, issue 8, article kfag094
Dates: published online 30 July 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1093/toxsci/kfag094 · PMID 42530889 · PMCID PMC13493187 · OpenAlex W7171809073
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: extracellular electrophysiology (units, LFP) (modality), human (organism), epilepsy (population), cellular / molecular (subfield)
Methods: Statistics, Machine learning, Single-unit activity, calcium imaging
Keywords: SAR, CNS toxicity, drug development, drug discovery, seizure, ion channels, MEA, hiPSC neurons, iLASeizure
MeSH: Central Nervous System*, Ion Channels*, Animals, Drug Design, Humans, Structure-Activity Relationship (* major topic)
Topic: Nicotinic Acetylcholine Receptors Study (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: ApconiX; MedChemica
Citations: cited by 1 paper (Europe PMC); 52 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1093/toxsci/kfag094.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 9 keywords, 6 MeSH terms, 2 funders, 39 references.

Cite

This paper

Zolkiewski, L. A. K., Rockley, K. L., Roberts, R. A., Jennings, H. G., Maizières, M.-A., Jones, K., McDonagh, J. L., Newman, K., Griffen, E. J., Stacey, J. E., & Morton, M. J. (2026). Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity. Toxicological sciences : an official journal of the Society of Toxicology, 209(8), kfag094. https://doi.org/10.1093/toxsci/kfag094

BibTeX

@article{zolkiewski2026building,
author = {Zolkiewski, Louisa A K and Rockley, Kimberly L and Roberts, Ruth A and Jennings, Hannah G and Maizières, Magali-Anne and Jones, Karen and McDonagh, James L and Newman, Katie and Griffen, Ed J and Stacey, Jessica E and Morton, Michael J},
title = {{Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity}},
journal = {Toxicological sciences : an official journal of the Society of Toxicology},
year = {2026},
month = aug,
volume = {209},
number = {8},
pages = {kfag094},
publisher = {Oxford University Press},
issn = {1096-6080},
doi = {10.1093/toxsci/kfag094},
url = {https://doi.org/10.1093/toxsci/kfag094},
pmid = {42530889},
pmcid = {PMC13493187}
}

RIS

TY - JOUR
AU - Zolkiewski, Louisa A K
AU - Rockley, Kimberly L
AU - Roberts, Ruth A
AU - Jennings, Hannah G
AU - Maizières, Magali-Anne
AU - Jones, Karen
AU - McDonagh, James L
AU - Newman, Katie
AU - Griffen, Ed J
AU - Stacey, Jessica E
AU - Morton, Michael J
TI - Building structure activity relationships to avoid toxicity due to unwanted central nervous system ion channel activity
T2 - Toxicological sciences : an official journal of the Society of Toxicology
J2 - Toxicol Sci
PY - 2026
DA - 2026/08/01
VL - 209
IS - 8
SP - kfag094
SN - 1096-6080
PB - Oxford University Press
DO - 10.1093/toxsci/kfag094
UR - https://doi.org/10.1093/toxsci/kfag094
LA - en
ER -

CSL-JSON

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