Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults.
Overview
- Department of Environmental & Occupational Health, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Department of Internal Medicine‐Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston‐Salem, North Carolina, USA
- Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding, Charlestown, Massachusetts, USA
- Department of Physical Medicine & Rehabilitation, Harvard Medical School, Boston, Massachusetts, USA
- Department of Physical Medicine & Rehabilitation, Spaulding Rehab Hospital, Charlestown, Massachusetts, USA
- Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
- Atrium Health Wake Forest Baptist Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston‐Salem, North Carolina, USA
- Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest University School of Medicine, Winston‐Salem, North Carolina, USA
Abstract
Mobility decline with aging is a major health concern, associated with a higher risk for disability. Despite the prevalence of gait slowing in elderly adults, this issue has not been adequately addressed. The central nervous and skeletal muscle systems are key regulators of gait speed. However, direct molecular communication along the brain‐muscle axis and their interactions in mobility resilience remain poorly studied. Extracellular vesicles (EVs) have emerged as a key player in long‐distance inter‐cellular communication. Nevertheless, the potential of EVs as biological predictors of mobility resilience in older adults has not been studied. We used serum from 23 participants with gait speed > 1.0 m/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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The paper's code and data availability statement is in the Data section.
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Data
Data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in “Data Availability Statement”
Data Availability Statement
Raw small noncoding RNA sequencing data were submitted to GEO (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 5 keywords, 7 MeSH terms, 4 funders, 75 references.
Cite
This paper
Fitz, N. F., Kumar, A., Su, Y., Sharma, M., Singh, S., Koldamova, R., Lefterov, I., Sahu, A., Ambrosio, F., Rosano, C., & Deep, G. (2026). Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults. Aging cell, 25(4), e70470. https://
BibTeX
@article{fitz2026serum,
author = {Fitz, Nicholas F and Kumar, Ashish and Su, Yixin and Sharma, Mitu and Singh, Sangeeta and Koldamova, Radosveta and Lefterov, Iliya and Sahu, Amrita and Ambrosio, Fabrisia and Rosano, Caterina and Deep, Gagan},
title = {{Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults}},
journal = {Aging cell},
year = {2026},
month = apr,
volume = {25},
number = {4},
pages = {e70470},
publisher = {Wiley},
issn = {1474-9718},
doi = {10.1111/
url = {https://
pmid = {41940695},
pmcid = {PMC13052232}
}
RIS
TY - JOUR
AU - Fitz, Nicholas F
AU - Kumar, Ashish
AU - Su, Yixin
AU - Sharma, Mitu
AU - Singh, Sangeeta
AU - Koldamova, Radosveta
AU - Lefterov, Iliya
AU - Sahu, Amrita
AU - Ambrosio, Fabrisia
AU - Rosano, Caterina
AU - Deep, Gagan
TI - Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults
T2 - Aging cell
J2 - Aging Cell
PY - 2026
DA - 2026/
VL - 25
IS - 4
SP - e70470
SN - 1474-9718
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "Aging cell",
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"URL": "https://
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