Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage.
Overview
- Department of Neurosurgery, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College), The Translational Research Institute for Neurological Disorders of Wannan Medical College, Wuhu, Anhui, China
- The Institutes of Brain Science, Wannan Medical College, Wuhu, Anhui, China
Abstract
Background: Subarachnoid haemorrhage (SAH) is primarily caused by ruptured aneurysms with high mortality worldwide. Cuproptosis is a copper-induced cell death that regulates lipoylated tricarboxylic acid cycle proteins. The link between cuproptosis and SAH is unclear. To inhibit cuproptosis for SAH treatment, we designed brain-targeted delivery of siRNA to inhibit cuproptosis.
Methods: Transcriptome data of SAH related to cuprotosis were extracted from the Gene Expression Omnibus and defined using quantitative reverse transcription-PCR. We injected RVG-RBCEVs/
Results: Our findings revealed that three cuproptosis-related genes (CRGs) were differentially expressed. The RVG peptides were conjugated to the red blood cell extracellular vesicle surface by bio-orthogonal click chemistry reactions, and then the loading of siRNA was conducted. RVG-RBCEVs/
Conclusions: These findings suggest that cuprotosis is critical for inducing neural injury after SAH. Neuron-targeted RVG-RBCEVs/
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in the text, “Data collection and CRG identification”
Data availability statement
Data are available upon reasonable request.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 4 keywords, 13 MeSH terms, 2 funders, 35 references.
Cite
This paper
Xu, P., Fang, J., Qin, F., Xia, D., Yuan, J., Sheng, B., & Lai, N. (2026). Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage. Stroke and vascular neurology, 11(2), e004248. https://
BibTeX
@article{xu2026brain,
author = {Xu, Pengcheng and Fang, Jian and Qin, Feiyun and Xia, Dayong and Yuan, Jinlong and Sheng, Bin and Lai, Niansheng},
title = {{Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage}},
journal = {Stroke and vascular neurology},
year = {2026},
month = apr,
volume = {11},
number = {2},
pages = {e004248},
publisher = {BMJ Publishing Group},
issn = {2059-8688},
doi = {10.1136/
url = {https://
pmid = {40953925},
pmcid = {PMC13151895}
}
RIS
TY - JOUR
AU - Xu, Pengcheng
AU - Fang, Jian
AU - Qin, Feiyun
AU - Xia, Dayong
AU - Yuan, Jinlong
AU - Sheng, Bin
AU - Lai, Niansheng
TI - Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage
T2 - Stroke and vascular neurology
J2 - Stroke Vasc Neurol
PY - 2026
DA - 2026/
VL - 11
IS - 2
SP - e004248
SN - 2059-8688
PB - BMJ Publishing Group
DO - 10.1136/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1136/
"type": "article-journal",
"title": "Brain-targeted extracellular vesicles for anti-cuproptosis therapy in subarachnoid haemorrhage",
"container-title": "Stroke and vascular neurology",
"author": [
{
"family": "Xu",
"given": "Pengcheng"
},
{
"family": "Fang",
"given": "Jian"
},
{
"family": "Qin",
"given": "Feiyun"
},
{
"family": "Xia",
"given": "Dayong"
},
{
"family": "Yuan",
"given": "Jinlong"
},
{
"family": "Sheng",
"given": "Bin"
},
{
"family": "Lai",
"given": "Niansheng"
}
],
"container-title-short":
"volume": "11",
"issue": "2",
"page": "e004248",
"DOI": "10.1136/
"PMID": "40953925",
"PMCID": "PMC13151895",
"ISSN": "2059-8688",
"publisher": "BMJ Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
27
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1002/jev2.70295
- RVG-Modified BMSCs-Derived Small Extracellular Vesicles Loaded With miR-21 Alleviate Neuronal Injury Resulted From Excessive Autophagy via Targeting PTEN/
Akt/ mTOR Pathway After Cerebral Ischaemia. Journal: Journal of extracellular vesiclesIn common: stroke, mouse, 2 references - [2] doi:10.21037/tcr-2026-0404
- A cuproptosis-related lncRNAs-based risk signature for predicting prognosis and immune status in glioma.Journal: Translational cancer researchIn common: 2 references
- [3] doi:10.1111/acel.70470
- Serum-Derived Extracellular Vesicles as Biological Indicator of Mobility Resilience in Older Adults.Journal: Aging cellIn common: 2 references
- [4] doi:10.1002/cns.71080
- Vorinostat Mitigates Early Brain Injury Following Subarachnoid Hemorrhage Through Modulation of the C3aR1/
TGF-β/ Smad Pathway. Journal: CNS neuroscience & therapeuticsIn common: stroke, mouse, 1 reference - [5] doi:10.1038/s12276-026-01764-6 [code]
- Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment.Journal: Experimental & molecular medicineIn common: stroke, mouse, 1 reference
- [6] doi:10.2147/ijgm.s581629
- A Five-Gene PANoptosis Signature Correlates with Immune Infiltration and Secondary Brain Injury in Intracerebral Hemorrhage.Journal: International journal of general medicineIn common: stroke, 1 reference
- [7] doi:10.1002/advs.76336
- Biodegradable Acoustic Targeting for Ultrasound-Supported Gene Therapy (BATUS) in Glioblastoma.Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)In common: mouse, 1 reference
- [8] doi:
- Mesenchymal stem cell-derived extracellular vesicles ameliorate heat stroke-induced hippocampal injury and modulate VIM-AS1-associated miR-34a-5p/
Per2 signaling Journal: Frontiers in immunologyIn common: mouse, 1 reference - [9] doi:10.1002/ctm2.70756
- Chronic stress-induced brain-derived small extracellular vesicles promote colorectal cancer through Treg differentiation.Journal: Clinical and translational medicineIn common: mouse, 1 reference
- [10] doi:10.7150/thno.134644
- miR-15a-5p outperforms anti-VEGF drug in ocular neovascularization by providing dual anti-angiogenic and neuroprotective effects.Journal: TheranosticsIn common: mouse, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.