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A Systematic Review of Aperiodic Neural Activity in Clinical Investigations

Code ↔ Paper

2 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 2 matches
  1. [1] § Methods ↔ notebooks/local/terms.py, lines 6–70 · score 0.78 · spectral slope, aperiodic slope, spectral exponent, disorder terms, aperiodic exponent, disease
  2. [2] § Results › Summaries Within Disorders › ADHD ↔ notebooks/local/terms.py, lines 6–70 · score 0.58 · attention deficit, hyperactivity disorder, aperiodic exponent, ADHD, treatment, diagnosis

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

Python · 74 lines · 2.1 KB · MIT · 2 matches

  1. """"Term definitions."""
  3. ####################################################################################################
  4. ####################################################################################################
  6. TERMS = {
  8. # Set the aperiodic measure terms
  9. 'AP' : [
  10. [
  11. 'aperiodic exponent',
  12. 'aperiodic slope',
  13. 'spectral exponent',
  14. 'spectral slope',
  15. '1/f slope',
  16. '1/f exponent',
  17. ],
  18. ],
  20. # Set general clinical terms
  21. 'CLINICAL' : [
  22. ['clinical'],
  23. ['disorder', 'disease'],
  24. ['biomarker'],
  25. ['diagnosis', 'diagnostic'],
  26. ['treatment'],
  27. ],
  29. # Set disorder terms
  30. 'DISORDERS' : [
  31. ["parkinson's"],
  32. ['epilepsy', 'seizure'],
  33. ['ADHD', 'attention deficit hyperactivity disorder'],
  34. ['autism', 'ASD'],
  35. ['alzheimers', 'dementia'],
  36. ['disorders of consciousness', 'coma', 'locked-in'],
  37. ['depression', 'MDD', 'major depressive disorder'],
  38. ['schizophrenia'],
  39. ['stroke'],
  40. ['dystonia'],
  41. ['TBI', 'traumatic brain injury'],
  42. ['dyslexia'],
  43. ['glioma'],
  44. ["huntington's"],
  45. ['multiple sclerosis'],
  46. ['PTSD', 'post traumatic stress disorder'],
  47. ['REM sleep behavior disorder'],
  48. ['rett syndrome'],
  49. ['22q.11.2'],
  50. ['ALS', 'amyotrophic lateral sclerosis', "Lou Gehrig's disease"],
  51. ['anxiety'],
  52. ['CDKL5 deficiency disorder'],
  53. ['chronic pain'],
  54. ['concussion'],
  55. ['down syndrome'],
  56. ['fibromyalgia'],
  57. ['fragile X'],
  58. ['insomnia'],
  59. ['NF1'],
  60. ['NREM parasomina'],
  61. ['OCD', 'obsessive compulsive disorder'],
  62. ['STXBP1'],
  63. ['tinnitus'],
  64. ['tourette'],
  65. ['tuberous sclerosis complex'],
  66. ['delirium'],
  67. ['stutter'],
  68. ['cancer'],
  69. ],
  70. }
  72. # Define exclusion terms
  73. EXCLUSIONS = ['acid', 'protein', 'ion', 'enzyme', 'ultrasound',
  74. 'cancer', 'halide', 'spectroscopy', 'iodide', 'tissue']

terms.py at commit e5aa037, under MIT · at the source

Overview

Authors: Thomas Donoghue1
ORCID iDs: Thomas Donoghue
  1. Division of Psychology, Communication and Human Neuroscience, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK
Institutions: University of Manchester (United Kingdom)
Journal: n/a, volume 62, issue 7, article e70255
Dates: received 6 June 2025; accepted 29 August 2025; published online 11 October 2025; in print October 2025
Type: Review · Language: English
License: none stated
Identifiers: DOI 10.1111/ejn.70255 · PMCID PMC12514750 · OpenAlex W4415072487
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: EEG (modality), human (organism), clinical / translational (subfield)
Methods: Spectral & time-frequency, Statistics
Keywords: aperiodic exponent, aperiodic neural activity, biomarker, clinical neurophysiology, EI ratio, spectral parameterization, spectral slope
MeSH: Brain*, Mental Disorders*, Nervous System Diseases*, Electroencephalography, Humans (* major topic)
Topic: Neural dynamics and brain function (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Citations: cited by 51 papers (Europe PMC); 239 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (none stated) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Repository

Its files are read in the Code ↔ Paper reader above, with 2 matches between paragraphs and lines of code.

TomDonoghue/AperiodicClinical

License: MIT
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: e5aa0378e7dbd0f9853d699218b4a4c7b53ca7b9, 28 March 2026
Languages: Jupyter (6), Python (4)
Size: 24 files, 10 scripts
Software Heritage: not archived
Found in: “Data Availability Statement”
Holds: README, license file, CITATION.cff, environment (requirements.txt), 6 notebooks
Not found: tests, continuous integration, documentation
Tools: seaborn (7 files), NumPy (5 files), Matplotlib (4 files), pandas (4 files), NeuroDSP (2 files), specparam (formerly FOOOF) (2 files)
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
12 files
At the source: github.com/TomDonoghue/AperiodicClinical

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 10 scripts, each with its path and the digest of its content;
  • 2 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (none stated) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1111/ejn.70255.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Publisher: n/a → Wiley

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 1 author, 7 keywords, 5 MeSH terms, 239 references.

Cite

This paper

Donoghue, T. (2025). A Systematic Review of Aperiodic Neural Activity in Clinical Investigations. The European Journal of Neuroscience, 62(7), e70255. https://doi.org/10.1111/ejn.70255

BibTeX

@article{donoghue2025systematic,
author = {Donoghue, Thomas},
title = {{A Systematic Review of Aperiodic Neural Activity in Clinical Investigations}},
journal = {The European Journal of Neuroscience},
year = {2025},
volume = {62},
number = {7},
pages = {e70255},
publisher = {Wiley},
issn = {0953-816X},
doi = {10.1111/ejn.70255},
url = {https://doi.org/10.1111/ejn.70255},
pmcid = {PMC12514750}
}

RIS

TY - JOUR
AU - Donoghue, Thomas
TI - A Systematic Review of Aperiodic Neural Activity in Clinical Investigations
T2 - The European Journal of Neuroscience
J2 - Eur J Neurosci
PY - 2025
DA - 2025
VL - 62
IS - 7
SP - e70255
SN - 0953-816X
PB - Wiley
DO - 10.1111/ejn.70255
UR - https://doi.org/10.1111/ejn.70255
LA - en
ER -

CSL-JSON

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"id": "10.1111/ejn.70255",
"type": "article-journal",
"title": "A Systematic Review of Aperiodic Neural Activity in Clinical Investigations",
"container-title": "The European Journal of Neuroscience",
"author": [
{
"family": "Donoghue",
"given": "Thomas"
}
],
"container-title-short": "Eur J Neurosci",
"volume": "62",
"issue": "7",
"page": "e70255",
"DOI": "10.1111/ejn.70255",
"PMCID": "PMC12514750",
"ISSN": "0953-816X",
"publisher": "Wiley",
"URL": "https://doi.org/10.1111/ejn.70255",
"language": "en",
"issued": {
"date-parts": [
[
2025
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]
}
}

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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