CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight.
Overview
and 13 other authors
Amir Salehi Lashkajani1, Yuqian Zhang1, Patrick McCarthy1, Xuesong Hu1, Alexander Antrobus1, Chloe Maine1, Matt Thackrah1, Matthew Taylor Valley1, Benjamin Crutchley1, Dawid Borycki1, Tanja Dragojević1, Claus Lindner1, Robert James Cooper1,2- CoMind Technologies Ltd., London, United Kingdom
- University College London, Biomedical Optics Research Laboratory, Department of Medical Physics and Biomedical Engineering, London, United Kingdom
Abstract
Significance: Continuous, noninvasive monitoring of cerebral blood flow (CBF) at the bedside is a critical unmet clinical need and a long-standing goal of biomedical optics. Despite extensive development, no optical measurement of CBF has achieved routine clinical use.
Aim: We aim to demonstrate and validate CoMind R1, a time-resolved interferometric neuromonitoring system designed to noninvasively measure CBF at pulsatile rates.
Approach: CoMind R1 integrates numerous advances, including a high-power, linearly swept 1064 nm laser, multimode collection, parallelized detection, and real-time processing. Performance is evaluated with homogeneous and dynamic bi-layer phantoms and in vivo studies of adults at rest and during visual stimulation.
Results: CoMind R1 achieves an instrument response function width of 120 ps and exhibits no significant drift over 24 h. In vivo data from 25 adults show consistent pulsatile blood flow waveforms at times-of-flight averaging 1.2 ns, exceeding the prior art. Visual stimulation produces significant, time-of-flight-dependent
Conclusions: CoMind R1 consistently achieves time-of-flight resolved measurements of pulsatile blood flow at the late times-of-flight necessary to ensure a brain-dominated signal in the typical adult. CoMind R1 thus provides cerebral sensitivity and tissue specificity in a scalable, cost-effective architecture and advances optical monitoring of CBF toward clinical translation.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data and code underlying the results presented in this paper are not publicly available at this time but may be obtained from the authors upon reasonable request.
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 33 authors, 5 keywords, 63 references.
Cite
This paper
Parfentyeva, V., Behera, A., Avtzi, S., Tran-Van-Minh, A., Etard, O., Freer, S., Tambe, T., Mehmed, A., Isufaj, A., Goodrich, J., Ibrahim, Y., Singh, N., Darabi, S., Villar Sanjurjo, P., Malde, S., Ali, T., Kim, Y., Sturniolo, S., Ruesch, A., . . . Cooper, R. J. (2026). CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight. Neurophotonics, 13(2), 025002. https://
BibTeX
@article{parfentyeva2026
author = {Parfentyeva, Veronika and Behera, Anurag and Avtzi, Stella and Tran-Van-Minh, Alexandra and Etard, Octave and Freer, Suzanna and Tambe, Tanvi and Mehmed, Ali and Isufaj, Artur and Goodrich, Jan and Ibrahim, Youssef and Singh, Navjit and Darabi, Saeed and Villar Sanjurjo, Pablo and Malde, Sujit and Ali, Taimoor and Kim, Yoojin and Sturniolo, Simone and Ruesch, Alexander and Hill, Dominic William and Salehi Lashkajani, Amir and Zhang, Yuqian and McCarthy, Patrick and Hu, Xuesong and Antrobus, Alexander and Maine, Chloe and Thackrah, Matt and Valley, Matthew Taylor and Crutchley, Benjamin and Borycki, Dawid and Dragojević, Tanja and Lindner, Claus and Cooper, Robert James},
title = {{CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight}},
journal = {Neurophotonics},
year = {2026},
month = mar,
volume = {13},
number = {2},
pages = {025002},
publisher = {Society of Photo-Optical Instrumentation Engineers},
issn = {2329-423X},
doi = {10.1117/
url = {https://
pmid = {41918681},
pmcid = {PMC13033898}
}
RIS
TY - JOUR
AU - Parfentyeva, Veronika
AU - Behera, Anurag
AU - Avtzi, Stella
AU - Tran-Van-Minh, Alexandra
AU - Etard, Octave
AU - Freer, Suzanna
AU - Tambe, Tanvi
AU - Mehmed, Ali
AU - Isufaj, Artur
AU - Goodrich, Jan
AU - Ibrahim, Youssef
AU - Singh, Navjit
AU - Darabi, Saeed
AU - Villar Sanjurjo, Pablo
AU - Malde, Sujit
AU - Ali, Taimoor
AU - Kim, Yoojin
AU - Sturniolo, Simone
AU - Ruesch, Alexander
AU - Hill, Dominic William
AU - Salehi Lashkajani, Amir
AU - Zhang, Yuqian
AU - McCarthy, Patrick
AU - Hu, Xuesong
AU - Antrobus, Alexander
AU - Maine, Chloe
AU - Thackrah, Matt
AU - Valley, Matthew Taylor
AU - Crutchley, Benjamin
AU - Borycki, Dawid
AU - Dragojević, Tanja
AU - Lindner, Claus
AU - Cooper, Robert James
TI - CoMind R1: a time-resolved interferometric optical neuromonitoring system for pulsatile cerebral blood flow measurement at late times-of-flight
T2 - Neurophotonics
J2 - Neurophotonics
PY - 2026
DA - 2026/
VL - 13
IS - 2
SP - 025002
SN - 2329-423X
PB - Society of Photo-Optical Instrumentation Engineers
DO - 10.1117/
UR - https://
LA - en
ER -
CSL-JSON
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