Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.

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Paper

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The authors' code

MATLAB · 56 lines · 1.3 KB · CC-BY-4.0

darn=[]
dar=reshape(rr1([1:nimtr*ntr]+noff,:),[nimtr ntr size(rr1,2)]);
for mm=1:4, darn(:,:,mm)=dar(:,:,mm)./(ones(150,1)*squeeze(mean(dar(1:25,:,mm),1))); end;
%figure; plot(dar(:,:,1))
spacing = 1;
figure;
hold on
yshift=0;
wROI=1;
for iii = 1:size(dar,2)
plot(tt,dar(:,iii,wROI)+yshift)
yshift=yshift+spacing;
end
plot(tt,rr1a(:,wROI)-spacing,'k','Linewidth',3)
%figure; plot(dar(:,:,1))
%% my additions
yproj2max_darn=[];
yproj2max_dar=reshape(yproj2max([1:nimtr*ntr]+noff,:),[nimtr ntr size(yproj2max,2)]);
for mm=1:3, yproj2max_darn(:,:,mm)=yproj2max_dar(:,:,mm)./(ones(150,1)*squeeze(mean(yproj2max_dar(1:25,:,mm),1))); end;
%yproj2max_a=squeeze(mean(reshape(yproj2max([1:nimtr*ntr]+noff,:),[nimtr ntr size(yproj2max,2)]),2));
%yproj2max_an=yproj2max_a./(ones(size(yproj2max_a,1),1)*mean(yproj2max_a(1:nbase,:),1));
spacing = 1;
figure;
hold on
yshift=0;
wROI=1;
for iii = 1:size(yproj2max_dar,2)
plot(tt,yproj2max_dar(:,iii,wROI)+yshift)
yshift=yshift+spacing;
end
plot(tt,yproj2max_a(:,wROI)-spacing,'k','Linewidth',3)
dar=reshape(rr1([1:nimtr*ntr]+noff,:),[nimtr ntr size(rr1,2)]);
%figure; plot(dar(:,:,1))
spacing = 2;
figure;
hold on
yshift=0;
wROI=1;
for iii = 1:size(dar,2)
plot(tt,dar(:,iii,wROI)+yshift)
yshift=yshift+spacing;
end
plot(tt,rr1a(:,wROI)-spacing,'k','Linewidth',3)

AllTrials.m, under CC-BY-4.0 · at the source

Overview

Authors: Fernanda Juarez Anaya¹, Jiwon Kim¹, Sarah E. Ross^1,2, Alberto L. Vazquez^3,4

ORCID iDs: Fernanda Juarez Anaya, Jiwon Kim, Sarah E. Ross, Alberto L. Vazquez

Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA

Institutions: University of Pittsburgh (United States)

Journal: Science advances, volume 12, issue 27, article eadx5109

Dates: received 17 March 2025; accepted 18 May 2026; published online 3 July 2026; in print July 2026

Type: Research article · Language: English

License: CC BY-NC

Identifiers: DOI 10.1126/sciadv.adx5109 · PMID 42397904 · PMCID PMC13330815 · OpenAlex W7167240177

Open access: gold, a free copy (OpenAlex)

Status: code verified

Categories: mouse (organism), stroke (population), cellular / molecular (subfield)

Methods: Connectivity, Statistics, Evoked potentials, fMRI & imaging, Single-unit activity, calcium imaging, Smoothing, state filtering, decompositions, Physiology & signal measures

MeSH: Cerebral Cortex*, Neurons*, Neurovascular Coupling*, Nitric Oxide*, Receptors, Neurokinin-1*, Substance P*, Animals, Astrocytes, Calcium, Calcium Signaling, Cerebrovascular Circulation, Mice, Nitric Oxide Synthase Type I, Vasodilation (* major topic)

Journal subjects: Neuroscience, Cell Biology

Topic: Neuroscience of respiration and sleep (Endocrine and Autonomic Systems, Neuroscience), according to OpenAlex

Funding: National Institutes (F31-NS132422, R01-NS090444, R01-NS117515, R01-NS119410)

Citations: not cited yet (Europe PMC); 67 references in the paper

Abstract

Neuronal activity–driven increases in cerebral blood flow (CBF), known as neurovascular coupling (NVC), are crucial for sustaining the metabolic demands of the brain. Our group has found that Tacr1 neurons, a subset of somatostatin neurons expressing the substance P (SP) receptor and neuronal nitric oxide synthase (nNOS), exert a disproportionately large regulation of CBF. Here, we use two-photon imaging to show that Tacr1 neurons regulate CBF through nitric oxide (NO) release and SP-receptor signaling . We identify astrocytic calcium (Ca2+) transients as a secondary response to vasodilation. To identify potential sources of SP in somatosensory cortex, viral mapping revealed Tac1-positive neurons locally, predominantly among parvalbumin (PV) neurons, as well as Tac1-positive long-range projections from perirhinal cortex. Functional analyses indicate that PV neurons regulate CBF through a Tacr1 neuron dependent pathway. These findings suggest a sequential mechanism whereby Tacr1 neurons respond to SP to release NO, inducing vasodilation and driving astrocytic Ca2+ signaling.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above.

Zenodo 10656014

License: CC-BY-4.0

State: the link answers, verified on 27 September 2026

Evidence: files inventoried

Size: 1 file

Software Heritage: not checked

Found in: “Data, code, and materials availability:”

Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation

Tools: Image Processing Toolbox (17 files), Statistics and Machine Learning Toolbox (11 files), Optimization Toolbox (3 files), Signal Processing Toolbox (1 file)

Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)

27 September 2026: the link answers (HTTP 200)

149 files

AllTrials.m — MATLAB, 56 lines
BarGraphsMod.m — MATLAB, 25 lines
Bargraph.m — MATLAB, 45 lines
Baseline.m — MATLAB, 85 lines
BaselineMod.m — MATLAB, 63 lines
ControlCombined.m — MATLAB, 105 lines
OIS_corr.m — MATLAB, 130 lines
OIS_corr2.m — MATLAB, 42 lines
PeakAmplitude.m — MATLAB, 64 lines
PostStim.m — MATLAB, 24 lines
StimCombined.m — MATLAB, 167 lines
StimCombined10072019 copy.m — MATLAB, 150 lines
StimCombined10072019.m — MATLAB, 152 lines
StimCombinedSM.m — MATLAB, 163 lines
averageOIS.m — MATLAB, 127 lines
averageOIS2.m — MATLAB, 127 lines
averageOIS3.m — MATLAB, 128 lines
base64decode.m — MATLAB, 104 lines
base64encode.m — MATLAB, 160 lines
bio_scr1all_drcr.m — MATLAB, 70 lines
bio_scr1all_sr.m — MATLAB, 137 lines
bio_scr1all_sr_fig.m — MATLAB, 212 lines
bio_scr2.m — MATLAB, 65 lines
bio_scr2_fig.m — MATLAB, 85 lines
biopac_binary2.m — MATLAB, 186 lines
calcCentroid.m — MATLAB, 103 lines
calcRadius2.m — MATLAB, 58 lines
calcRadius2b.m — MATLAB, 67 lines
calcRadius3.m — MATLAB, 34 lines
calcRadius3b.m — MATLAB, 54 lines
calcRadius3b_up.m — MATLAB, 75 lines
calcRadius4.m — MATLAB, 97 lines
calcRadius4rtst.m — MATLAB, 14 lines
calcRadius6.m — MATLAB, 57 lines
calcRadius6_up.m — MATLAB, 22 lines
calcRadius8.m — MATLAB, 101 lines
chkCellRing2bb.m — MATLAB, 298 lines
dartest.m — MATLAB, 32 lines
dftregistration.m — MATLAB, 212 lines
dofontsize.m — MATLAB, 12 lines
dopapersize.m — MATLAB, 10 lines
editMask1.m — MATLAB, 106 lines
editmask.m — MATLAB, 91 lines
editmask2.m — MATLAB, 99 lines
estLaserPower.m — MATLAB, 65 lines
fatlines.m — MATLAB, 8 lines
fermi1d.m — MATLAB, 51 lines
gen_object_display.m — MATLAB, 122 lines
getBiopacSamples.m — MATLAB, 73 lines
getRectImGrid.m — MATLAB, 71 lines
getRectImGrid2.m — MATLAB, 98 lines
getSpectroEnv.m — MATLAB, 77 lines
getStkMaskTC.m — MATLAB, 185 lines
getTrigLoc.m — MATLAB, 76 lines
homocor.m — MATLAB, 155 lines
homocorOIS.m — MATLAB, 195 lines
im_overlay4.m — MATLAB, 72 lines
im_smooth.m — MATLAB, 73 lines
myOISmap1.m — MATLAB, 145 lines
myOISscr1.m — MATLAB, 566 lines
myOISscr1_convert.m — MATLAB, 22 lines
myOISscr1_new.m — MATLAB, 646 lines
myOISscr1_wrap.m — MATLAB, 143 lines
myOISscr2g.m — MATLAB, 158 lines
myTBfix1.m — MATLAB, 77 lines
myaffine2d_label.m — MATLAB, 23 lines
myaffine2d_m.m — MATLAB, 37 lines
myaffine2d_scr.m — MATLAB, 127 lines
myangle2.m — MATLAB, 17 lines
myarfilt.m — MATLAB, 38 lines
mydftreg.m — MATLAB, 29 lines
mydftreg_1d.m — MATLAB, 30 lines
mydftreg_vol.m — MATLAB, 27 lines
myfilter.m — MATLAB, 29 lines
myfilter1.m — MATLAB, 63 lines
myfilter2.m — MATLAB, 55 lines
myginput.m — MATLAB, 204 lines
mymode.m — MATLAB, 25 lines
mysmooth.m — MATLAB, 20 lines
normch.m — MATLAB, 36 lines
parseBiopac.m — MATLAB, 86 lines
parsePrairieXML.m — MATLAB, 125 lines
pixtoim.m — MATLAB, 30 lines
plotBiopac.m — MATLAB, 276 lines
plotmany.m — MATLAB, 54 lines
plotmsd4.m — MATLAB, 68 lines
plotmsd4Exclude.m — MATLAB, 57 lines
plotmsd4Exclude2.m — MATLAB, 57 lines
positionMask2d.m — MATLAB, 119 lines
positionMask2d_many.m — MATLAB, 88 lines
positionMask2d_wrap.m — MATLAB, 46 lines
processBiopac4.m — MATLAB, 54 lines
processBiopacStruc2.m — MATLAB, 371 lines
processBiopacStruc2old.m — MATLAB, 309 lines
quickmap_scr.m — MATLAB, 46 lines
quickmap_scr2.m — MATLAB, 46 lines
quickmap_scr3.m — MATLAB, 46 lines
r2t.m — MATLAB, 15 lines
readOIS.m — MATLAB, 101 lines
readOIS2.m — MATLAB, 87 lines
readOIS3.m — MATLAB, 94 lines
readPrairie copy.m — MATLAB, 54 lines
readPrairie.m — MATLAB, 54 lines
readPrairie2 copy.m — MATLAB, 131 lines
readPrairie2.m — MATLAB, 131 lines
readPrairieLS.m — MATLAB, 137 lines
readlsm.m — MATLAB, 44 lines
readraw.m — MATLAB, 113 lines
rect.m — MATLAB, 32 lines
reportBiopacImageIntake1.m — MATLAB, 59 lines
ring.m — MATLAB, 14 lines
ring2.m — MATLAB, 49 lines
rot2d.m — MATLAB, 16 lines
rot2d_f.m — MATLAB, 15 lines
rot2d_nf.m — MATLAB, 13 lines
rot3d_f.m — MATLAB, 49 lines
rot3d_nf.m — MATLAB, 22 lines
scr4883.m — MATLAB, 248 lines
scrWhiskerP.m — MATLAB, 27 lines
selectMask.m — MATLAB, 95 lines
setlinecolor.m — MATLAB, 40 lines
setpapersize.m — MATLAB, 48 lines
show.m — MATLAB, 53 lines
showMovie.m — MATLAB, 142 lines
showOISaverage.m — MATLAB, 71 lines
showProj.m — MATLAB, 109 lines
showStack.m — MATLAB, 210 lines
showStack2.m — MATLAB, 210 lines
show_positionMask2d.m — MATLAB, 25 lines
stackplot.m — MATLAB, 32 lines
stkFilt.m — MATLAB, 52 lines
stkProj.m — MATLAB, 99 lines
str2varname.m — MATLAB, 22 lines
tcdetrend.m — MATLAB, 44 lines
test.m — MATLAB, 24 lines
tiffread2 copy.m — MATLAB, 530 lines
tiffread2.m — MATLAB, 530 lines
tiffread2c.m — MATLAB, 535 lines
tile3d.m — MATLAB, 81 lines
twop_filt copy.m — MATLAB, 94 lines
twop_filt.m — MATLAB, 37 lines
volbin.m — MATLAB, 37 lines
volzAdj1.m — MATLAB, 43 lines
xml_read.m — MATLAB, 458 lines
xml_tutorial_script.m — MATLAB, 641 lines
xml_write.m — MATLAB, 394 lines
xmlwrite_xerces.m — MATLAB, 109 lines
ybin.m — MATLAB, 24 lines
ybin2.m — MATLAB, 35 lines

At the source: zenodo.org/records/10656014

neuroimlabpitt/tacr1-paper2024_functions

License: none: the authors keep all their rights

State: the link answers, verified on 27 September 2026

Evidence: files inventoried

Commit: 26aa78e31662666a75b3cb37324ad8e2b055dedc, 13 February 2024

Languages: MATLAB (149)

Size: 150 files, 149 scripts

Software Heritage: not archived

Found in: the Zenodo archive record

Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation

Tools: Image Processing Toolbox (17 files), Statistics and Machine Learning Toolbox (11 files), Optimization Toolbox (3 files), Signal Processing Toolbox (1 file)

Availability: 1 check, the latest on 27 September 2026: the link answers

27 September 2026: the link answers

149 files, not copied: shown from their source

OSCR keeps no copy of these files: this repository has no license that allows it. The reader above shows each one from its source, fetched by your browser at commit 26aa78e, when its fingerprint is the one OSCR verified. How this works.

AllTrials.m — MATLAB, 56 lines, shown from its source
BarGraphsMod.m — MATLAB, 25 lines, shown from its source
Bargraph.m — MATLAB, 45 lines, shown from its source
Baseline.m — MATLAB, 85 lines, shown from its source
BaselineMod.m — MATLAB, 63 lines, shown from its source
ControlCombined.m — MATLAB, 105 lines, shown from its source
OIS_corr.m — MATLAB, 130 lines, shown from its source
OIS_corr2.m — MATLAB, 42 lines, shown from its source
PeakAmplitude.m — MATLAB, 64 lines, shown from its source
PostStim.m — MATLAB, 24 lines, shown from its source
StimCombined.m — MATLAB, 167 lines, shown from its source
StimCombined10072019 copy.m — MATLAB, 150 lines, shown from its source
StimCombined10072019.m — MATLAB, 152 lines, shown from its source
StimCombinedSM.m — MATLAB, 163 lines, shown from its source
averageOIS.m — MATLAB, 127 lines, shown from its source
averageOIS2.m — MATLAB, 127 lines, shown from its source
averageOIS3.m — MATLAB, 128 lines, shown from its source
base64decode.m — MATLAB, 104 lines, shown from its source
base64encode.m — MATLAB, 160 lines, shown from its source
bio_scr1all_drcr.m — MATLAB, 70 lines, shown from its source
bio_scr1all_sr.m — MATLAB, 137 lines, shown from its source
bio_scr1all_sr_fig.m — MATLAB, 212 lines, shown from its source
bio_scr2.m — MATLAB, 65 lines, shown from its source
bio_scr2_fig.m — MATLAB, 85 lines, shown from its source
biopac_binary2.m — MATLAB, 186 lines, shown from its source
calcCentroid.m — MATLAB, 103 lines, shown from its source
calcRadius2.m — MATLAB, 58 lines, shown from its source
calcRadius2b.m — MATLAB, 67 lines, shown from its source
calcRadius3.m — MATLAB, 34 lines, shown from its source
calcRadius3b.m — MATLAB, 54 lines, shown from its source
calcRadius3b_up.m — MATLAB, 75 lines, shown from its source
calcRadius4.m — MATLAB, 97 lines, shown from its source
calcRadius4rtst.m — MATLAB, 14 lines, shown from its source
calcRadius6.m — MATLAB, 57 lines, shown from its source
calcRadius6_up.m — MATLAB, 22 lines, shown from its source
calcRadius8.m — MATLAB, 101 lines, shown from its source
chkCellRing2bb.m — MATLAB, 298 lines, shown from its source
dartest.m — MATLAB, 32 lines, shown from its source
dftregistration.m — MATLAB, 212 lines, shown from its source
dofontsize.m — MATLAB, 12 lines, shown from its source
dopapersize.m — MATLAB, 10 lines, shown from its source
editMask1.m — MATLAB, 106 lines, shown from its source
editmask.m — MATLAB, 91 lines, shown from its source
editmask2.m — MATLAB, 99 lines, shown from its source
estLaserPower.m — MATLAB, 65 lines, shown from its source
fatlines.m — MATLAB, 8 lines, shown from its source
fermi1d.m — MATLAB, 51 lines, shown from its source
gen_object_display.m — MATLAB, 122 lines, shown from its source
getBiopacSamples.m — MATLAB, 73 lines, shown from its source
getRectImGrid.m — MATLAB, 71 lines, shown from its source
getRectImGrid2.m — MATLAB, 98 lines, shown from its source
getSpectroEnv.m — MATLAB, 77 lines, shown from its source
getStkMaskTC.m — MATLAB, 185 lines, shown from its source
getTrigLoc.m — MATLAB, 76 lines, shown from its source
homocor.m — MATLAB, 155 lines, shown from its source
homocorOIS.m — MATLAB, 195 lines, shown from its source
im_overlay4.m — MATLAB, 72 lines, shown from its source
im_smooth.m — MATLAB, 73 lines, shown from its source
myOISmap1.m — MATLAB, 145 lines, shown from its source
myOISscr1.m — MATLAB, 566 lines, shown from its source
myOISscr1_convert.m — MATLAB, 22 lines, shown from its source
myOISscr1_new.m — MATLAB, 646 lines, shown from its source
myOISscr1_wrap.m — MATLAB, 143 lines, shown from its source
myOISscr2g.m — MATLAB, 158 lines, shown from its source
myTBfix1.m — MATLAB, 77 lines, shown from its source
myaffine2d_label.m — MATLAB, 23 lines, shown from its source
myaffine2d_m.m — MATLAB, 37 lines, shown from its source
myaffine2d_scr.m — MATLAB, 127 lines, shown from its source
myangle2.m — MATLAB, 17 lines, shown from its source
myarfilt.m — MATLAB, 38 lines, shown from its source
mydftreg.m — MATLAB, 29 lines, shown from its source
mydftreg_1d.m — MATLAB, 30 lines, shown from its source
mydftreg_vol.m — MATLAB, 27 lines, shown from its source
myfilter.m — MATLAB, 29 lines, shown from its source
myfilter1.m — MATLAB, 63 lines, shown from its source
myfilter2.m — MATLAB, 55 lines, shown from its source
myginput.m — MATLAB, 204 lines, shown from its source
mymode.m — MATLAB, 25 lines, shown from its source
mysmooth.m — MATLAB, 20 lines, shown from its source
normch.m — MATLAB, 36 lines, shown from its source
parseBiopac.m — MATLAB, 86 lines, shown from its source
parsePrairieXML.m — MATLAB, 125 lines, shown from its source
pixtoim.m — MATLAB, 30 lines, shown from its source
plotBiopac.m — MATLAB, 276 lines, shown from its source
plotmany.m — MATLAB, 54 lines, shown from its source
plotmsd4.m — MATLAB, 68 lines, shown from its source
plotmsd4Exclude.m — MATLAB, 57 lines, shown from its source
plotmsd4Exclude2.m — MATLAB, 57 lines, shown from its source
positionMask2d.m — MATLAB, 119 lines, shown from its source
positionMask2d_many.m — MATLAB, 88 lines, shown from its source
positionMask2d_wrap.m — MATLAB, 46 lines, shown from its source
processBiopac4.m — MATLAB, 54 lines, shown from its source
processBiopacStruc2.m — MATLAB, 371 lines, shown from its source
processBiopacStruc2old.m — MATLAB, 309 lines, shown from its source
quickmap_scr.m — MATLAB, 46 lines, shown from its source
quickmap_scr2.m — MATLAB, 46 lines, shown from its source
quickmap_scr3.m — MATLAB, 46 lines, shown from its source
r2t.m — MATLAB, 15 lines, shown from its source
readOIS.m — MATLAB, 101 lines, shown from its source
readOIS2.m — MATLAB, 87 lines, shown from its source
readOIS3.m — MATLAB, 94 lines, shown from its source
readPrairie copy.m — MATLAB, 54 lines, shown from its source
readPrairie.m — MATLAB, 54 lines, shown from its source
readPrairie2 copy.m — MATLAB, 131 lines, shown from its source
readPrairie2.m — MATLAB, 131 lines, shown from its source
readPrairieLS.m — MATLAB, 137 lines, shown from its source
readlsm.m — MATLAB, 44 lines, shown from its source
readraw.m — MATLAB, 113 lines, shown from its source
rect.m — MATLAB, 32 lines, shown from its source
reportBiopacImageIntake1.m — MATLAB, 59 lines, shown from its source
ring.m — MATLAB, 14 lines, shown from its source
ring2.m — MATLAB, 49 lines, shown from its source
rot2d.m — MATLAB, 16 lines, shown from its source
rot2d_f.m — MATLAB, 15 lines, shown from its source
rot2d_nf.m — MATLAB, 13 lines, shown from its source
rot3d_f.m — MATLAB, 49 lines, shown from its source
rot3d_nf.m — MATLAB, 22 lines, shown from its source
scr4883.m — MATLAB, 248 lines, shown from its source
scrWhiskerP.m — MATLAB, 27 lines, shown from its source
selectMask.m — MATLAB, 95 lines, shown from its source
setlinecolor.m — MATLAB, 40 lines, shown from its source
setpapersize.m — MATLAB, 48 lines, shown from its source
show.m — MATLAB, 53 lines, shown from its source
showMovie.m — MATLAB, 142 lines, shown from its source
showOISaverage.m — MATLAB, 71 lines, shown from its source
showProj.m — MATLAB, 109 lines, shown from its source
showStack.m — MATLAB, 210 lines, shown from its source
showStack2.m — MATLAB, 210 lines, shown from its source
show_positionMask2d.m — MATLAB, 25 lines, shown from its source
stackplot.m — MATLAB, 32 lines, shown from its source
stkFilt.m — MATLAB, 52 lines, shown from its source
stkProj.m — MATLAB, 99 lines, shown from its source
str2varname.m — MATLAB, 22 lines, shown from its source
tcdetrend.m — MATLAB, 44 lines, shown from its source
test.m — MATLAB, 24 lines, shown from its source
tiffread2 copy.m — MATLAB, 530 lines, shown from its source
tiffread2.m — MATLAB, 530 lines, shown from its source
tiffread2c.m — MATLAB, 535 lines, shown from its source
tile3d.m — MATLAB, 81 lines, shown from its source
twop_filt copy.m — MATLAB, 94 lines, shown from its source
twop_filt.m — MATLAB, 37 lines, shown from its source
volbin.m — MATLAB, 37 lines, shown from its source
volzAdj1.m — MATLAB, 43 lines, shown from its source
xml_read.m — MATLAB, 458 lines, shown from its source
xml_tutorial_script.m — MATLAB, 641 lines, shown from its source
xml_write.m — MATLAB, 394 lines, shown from its source
xmlwrite_xerces.m — MATLAB, 109 lines, shown from its source
ybin.m — MATLAB, 24 lines, shown from its source
ybin2.m — MATLAB, 35 lines, shown from its source

At the source: github.com/neuroimlabpitt/Tacr1-paper2024_functions/tree/Tacr1paper2024_functionsv1

The paper's code and data availability statement is in the Data section.

Tracing map

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2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
298 scripts, each with its path and the digest of its content;
no match between paragraphs and code yet;
neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

data.mendeley.com/drafts/y8rktzjwj3 — at Mendeley Data; found in “Data, code, and materials availability:”

Data, code, and materials availability

All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. All materials used in this study are commercially available. Custom code for analyzing calcium imaging and optogenetic data is available on Zenodo: https://zenodo.org/records/10656014. Calcium imaging and optogenetic mouse data have been processed and made publicly available on Mendeley dataset: https://data.mendeley.com/drafts/y8rktzjwj3. Beyond the data and analyses, this study did not generate new materials.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 14 MeSH terms, 1 funder, 67 references.

Cite

This paper

Juarez Anaya, F., Kim, J., Ross, S. E., & Vazquez, A. L. (2026). Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex. Science advances, 12(27), eadx5109. https://doi.org/10.1126/sciadv.adx5109

BibTeX

@article{juarezanaya2026substance, author = {Juarez Anaya, Fernanda and Kim, Jiwon and Ross, Sarah E. and Vazquez, Alberto L.}, title = {{Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex}}, journal = {Science advances}, year = {2026}, month = jul, volume = {12}, number = {27}, pages = {eadx5109}, publisher = {American Association for the Advancement of Science}, issn = {2375-2548}, doi = {10.1126/sciadv.adx5109}, url = {https://doi.org/10.1126/sciadv.adx5109}, pmid = {42397904}, pmcid = {PMC13330815} }

RIS

TY - JOUR AU - Juarez Anaya, Fernanda AU - Kim, Jiwon AU - Ross, Sarah E. AU - Vazquez, Alberto L. TI - Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex T2 - Science advances J2 - Sci Adv PY - 2026 DA - 2026/07/03 VL - 12 IS - 27 SP - eadx5109 SN - 2375-2548 PB - American Association for the Advancement of Science DO - 10.1126/sciadv.adx5109 UR - https://doi.org/10.1126/sciadv.adx5109 LA - en ER -

CSL-JSON

{ "id": "10.1126/sciadv.adx5109", "type": "article-journal", "title": "Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex", "container-title": "Science advances", "author": [ { "family": "Juarez Anaya", "given": "Fernanda" }, { "family": "Kim", "given": "Jiwon" }, { "family": "Ross", "given": "Sarah E." }, { "family": "Vazquez", "given": "Alberto L." } ], "container-title-short": "Sci Adv", "volume": "12", "issue": "27", "page": "eadx5109", "DOI": "10.1126/sciadv.adx5109", "PMID": "42397904", "PMCID": "PMC13330815", "ISSN": "2375-2548", "publisher": "American Association for the Advancement of Science", "URL": "https://doi.org/10.1126/sciadv.adx5109", "language": "en", "issued": { "date-parts": [ [ 2026, 7, 3 ] ] } }

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