Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans.
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- [1] § MATERIALS AND METHODS › Statistical analyses › Deformation-based morphometry ↔ dbm.sh, lines 394–449 · score 0.62 · deformation field, Jacobian determinants, geometric, mask, DBM
- [2] § MATERIALS AND METHODS › Statistical analyses › Deformation-based morphometry ↔ twolevel_dbm.py, lines 742–810 · score 0.53 · Jacobian determinants, mni, deformation, morphometry, DBM, field
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Shell · 592 lines · 26 KB · other · 1 match
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Overview
13 affiliations
- Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
- Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
- Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada
- Division of Neurosurgery, The Hospital for Sick Children, Toronto, Ontario, Canada
- Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada
- Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Ontario, Canada
- Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
- Oxford Centre for Integrative Neuroimaging, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford, UK
- Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
- Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Ontario, Canada
- Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada
- Department of Psychology, University of Toronto, Toronto, Ontario, Canada
- Division of Neurology, The Hospital for Sick Children, Toronto, Ontario, Canada
Abstract
Dysfunction of corticostriatal circuitry is related to the emergence of self-injurious behavior (SIB) in autism spectrum disorder (ASD). Despite mounting interest in circuit-based interventions for severe, refractory SIB, the lack of causal evidence linking modulation of corticostriatal networks to changes in SIB has limited the advancement of effective, targeted therapies. In this study, we demonstrate that electrical stimulation of the nucleus accumbens (NAcc) mitigates SIB and induces structural changes along corticostriatal circuits in a mouse model relevant for ASD and children with severe SIB undergoing NAcc-targeted deep brain stimulation. In BTBR T+ Itpr3tf/
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CoBrALab/twolevel_ants_dbm
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Data
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- doi:10.7910/
dvn/ — at the source; found in “Data, code, and materials availability:”kktjqc
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 15 MeSH terms, 1 funder, 141 references.
Cite
This paper
Zhang, K., Germann, J., Matin, R., Mithani, K., Ellegood, J., Suresh, H., Wong, S., Lerch, J. P., Nieman, B. J., Taylor, M. J., Breitbart, S., Fasano, A., Gorodetsky, C., Gouveia, F. V., & Ibrahim, G. M. (2026). Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans. Science advances, 12(15), eaeb5842. https://
BibTeX
@article{zhang2026regula
author = {Zhang, Kristina and Germann, Jurgen and Matin, Rafi and Mithani, Karim and Ellegood, Jacob and Suresh, Hrishikesh and Wong, Sammi and Lerch, Jason P and Nieman, Brian J and Taylor, Margot J and Breitbart, Sara and Fasano, Alfonso and Gorodetsky, Carolina and Gouveia, Flavia Venetucci and Ibrahim, George M},
title = {{Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans}},
journal = {Science advances},
year = {2026},
month = apr,
volume = {12},
number = {15},
pages = {eaeb5842},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {41961929},
pmcid = {PMC13068066}
}
RIS
TY - JOUR
AU - Zhang, Kristina
AU - Germann, Jurgen
AU - Matin, Rafi
AU - Mithani, Karim
AU - Ellegood, Jacob
AU - Suresh, Hrishikesh
AU - Wong, Sammi
AU - Lerch, Jason P
AU - Nieman, Brian J
AU - Taylor, Margot J
AU - Breitbart, Sara
AU - Fasano, Alfonso
AU - Gorodetsky, Carolina
AU - Gouveia, Flavia Venetucci
AU - Ibrahim, George M
TI - Regulation of autism-related self-injurious behavior by electrical stimulation of corticostriatal circuits in mice and humans
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 15
SP - eaeb5842
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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