Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.
Paper
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The authors' code
Shell · 21 lines · 415 B · CC-BY-4.0
- #!/bin/bash
- dir=/Volumes/public/Backup/horiDir/qst/TauLNM//PET_SUVR/PSP_GMandWM/
- cd ${dir}
- for subj in `ls `;do
- cd ${dir}/${subj}/
- mkdir -p ./roi/
- echo ${subj}
- for i in 3.27;do
- fslmaths spmT_0001.nii -thr ${i} -bin ./roi/roi_thr${i}.nii.gz
- flirt -in ./roi/roi_thr${i}.nii.gz -ref /Applications/NHPPipelines-master/global/templates/MNI152_T1_2mm.nii.gz -out ./roi/roi_thr${i}.nii.gz -applyxfm
- done
- done
00_mk_roi.sh, under CC-BY-4.0 · at the source
Overview
- Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan
- Department of Psychiatry, The Jikei University School of Medicine, Tokyo 105-8461, Japan
- Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan
- Center for Integrated Human Brain Science, Department of Functional Neurology & Neurosurgery, Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata 951-8585 Japan
- Department of Neuroetiology and Diagnostic Science, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan
Abstract
Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with motor and cognitive impairments. Whereas motor symptoms are associated with subcortical tau deposits, the mechanisms underlying the cognitive symptoms remain unclear due to heterogeneous and primarily subcortical distribution of pathological tau deposits. Here, we combined tau-PET (tau positron emission tomography) using a high-contrast probe we developed with a normative connectome in 37 patients with PSP and 48 healthy controls. We found that tau deposition sites functionally connected to a common cortical network that could not be derived from atrophy. This network predominantly overlapped with canonical action-mode and frontoparietal networks, which support adaptive, goal-directed behavior. Whereas the extent of primary tau deposition predicted motor symptoms, the normative connectivity strength from tau deposition sites to the identified cortical network explained the severity of cognitive deficits. These findings suggest a previously unknown mechanism that cognitive, but not motor, deficits in PSP arise from remote effects of tau deposition—independent of atrophy—via convergent connectivity to a common cortical network.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repositories
Its files are read in the Code ↔ Paper reader above.
Zenodo 18240936
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
- 27 September 2026: the link answers (HTTP 200)
10 files
- AtrophyNetworkMapping/
00_mk_roi.sh — Shell, 21 lines - AtrophyNetworkMapping/
01_VBMOverlap.sh — Shell, 73 lines - AtrophyNetworkMapping/
02_roianalysis.sh — Shell, 62 lines - AtrophyNetworkMapping/
03_groupanalysis_gsp.sh — Shell, 44 lines - TauNetworkMapping/
00_mk_roi.sh — Shell, 21 lines - TauNetworkMapping/
01_TauOverlap.sh — Shell, 62 lines - TauNetworkMapping/
02_roianalysis_gsp_1.sh — Shell, 57 lines - TauNetworkMapping/
03_groupanalysis_gsp.sh — Shell, 45 lines - calcROIvalue/
01_ROIvalue4tau.sh — Shell, 56 lines - calcROIvalue/
02_ROIvalue4atrophy.sh — Shell, 56 lines
yukihori1/2026-hori-psp_tau
e06dadc9718927941679bdaa26eb60b1141ea16f, 14 January 2026Availability: 1 check, the latest on 27 September 2026: the link answers
- 27 September 2026: the link answers
10 files, not copied: shown from their source
OSCR keeps no copy of these files: this repository has no license that allows it. The reader above shows each one from its source, fetched by your browser at commit e06dadc, when its fingerprint is the one OSCR verified. How this works.
- AtrophyNetworkMapping/
00_mk_roi.sh — Shell, 21 lines, shown from its source - AtrophyNetworkMapping/
01_VBMOverlap.sh — Shell, 73 lines, shown from its source - AtrophyNetworkMapping/
02_roianalysis.sh — Shell, 62 lines, shown from its source - AtrophyNetworkMapping/
03_groupanalysis_gsp.sh — Shell, 44 lines, shown from its source - TauNetworkMapping/
00_mk_roi.sh — Shell, 21 lines, shown from its source - TauNetworkMapping/
01_TauOverlap.sh — Shell, 62 lines, shown from its source - TauNetworkMapping/
02_roianalysis_gsp_1.sh — Shell, 57 lines, shown from its source - TauNetworkMapping/
03_groupanalysis_gsp.sh — Shell, 45 lines, shown from its source - calcROIvalue/
01_ROIvalue4tau.sh — Shell, 56 lines, shown from its source - calcROIvalue/
02_ROIvalue4atrophy.sh — Shell, 56 lines, shown from its source
The paper's code and data availability statement is in the Data section.
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
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- 20 scripts, each with its path and the digest of its content;
- no match between paragraphs and code yet;
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
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Data, code, and materials availability
All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 10 MeSH terms, 5 funders, 71 references.
Cite
This paper
Hori, Y., Endo, H., Tagai, K., Kataoka, Y., Goto, R., Kurose, S., Momota, Y., Kokubo, N., Seki, C., Moriguchi, S., Shimada, H., Shinotoh, H., Tokuda, T., Takahata, K., Minamimoto, T., Higuchi, M., & Hirabayashi, T. (2026). Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy. Science advances, 12(28), eaed0348. https://
BibTeX
@article{hori2026remote,
author = {Hori, Yuki and Endo, Hironobu and Tagai, Kenji and Kataoka, Yuko and Goto, Ryoji and Kurose, Shin and Momota, Yuki and Kokubo, Naomi and Seki, Chie and Moriguchi, Sho and Shimada, Hitoshi and Shinotoh, Hitoshi and Tokuda, Takahiko and Takahata, Keisuke and Minamimoto, Takafumi and Higuchi, Makoto and Hirabayashi, Toshiyuki},
title = {{Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy}},
journal = {Science advances},
year = {2026},
month = jul,
volume = {12},
number = {28},
pages = {eaed0348},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/
url = {https://
pmid = {42430462},
pmcid = {PMC13353357}
}
RIS
TY - JOUR
AU - Hori, Yuki
AU - Endo, Hironobu
AU - Tagai, Kenji
AU - Kataoka, Yuko
AU - Goto, Ryoji
AU - Kurose, Shin
AU - Momota, Yuki
AU - Kokubo, Naomi
AU - Seki, Chie
AU - Moriguchi, Sho
AU - Shimada, Hitoshi
AU - Shinotoh, Hitoshi
AU - Tokuda, Takahiko
AU - Takahata, Keisuke
AU - Minamimoto, Takafumi
AU - Higuchi, Makoto
AU - Hirabayashi, Toshiyuki
TI - Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/
VL - 12
IS - 28
SP - eaed0348
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/
UR - https://
LA - en
ER -
CSL-JSON
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