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Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy.

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Paper

Loaded from Europe PMC by your browser; OSCR does not store it: doi.org · Europe PMC

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The authors' code

Shell · 21 lines · 415 B · CC-BY-4.0

  1. #!/bin/bash
  4. dir=/Volumes/public/Backup/horiDir/qst/TauLNM//PET_SUVR/PSP_GMandWM/
  6. cd ${dir}
  8. for subj in `ls `;do
  10. cd ${dir}/${subj}/
  11. mkdir -p ./roi/
  13. echo ${subj}
  14. for i in 3.27;do
  15. fslmaths spmT_0001.nii -thr ${i} -bin ./roi/roi_thr${i}.nii.gz
  16. flirt -in ./roi/roi_thr${i}.nii.gz -ref /Applications/NHPPipelines-master/global/templates/MNI152_T1_2mm.nii.gz -out ./roi/roi_thr${i}.nii.gz -applyxfm
  17. done
  19. done

00_mk_roi.sh, under CC-BY-4.0 · at the source

Overview

Authors: Yuki Hori1, Hironobu Endo1, Kenji Tagai1,2, Yuko Kataoka1, Ryoji Goto1, Shin Kurose1,3, Yuki Momota1, Naomi Kokubo1, Chie Seki1, Sho Moriguchi1, Hitoshi Shimada1,4, Hitoshi Shinotoh1, Takahiko Tokuda1,5, Keisuke Takahata1,3, Takafumi Minamimoto1, Makoto Higuchi1,5, Toshiyuki Hirabayashi1
ORCID iDs: Yuki Hori, Hironobu Endo, Ryoji Goto, Shin Kurose, Naomi Kokubo, Chie Seki, Hitoshi Shimada, Keisuke Takahata, Takafumi Minamimoto, Makoto Higuchi, Toshiyuki Hirabayashi
  1. Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan
  2. Department of Psychiatry, The Jikei University School of Medicine, Tokyo 105-8461, Japan
  3. Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan
  4. Center for Integrated Human Brain Science, Department of Functional Neurology & Neurosurgery, Niigata University, 1-757 Asahimachidori, Chuo-ku, Niigata 951-8585 Japan
  5. Department of Neuroetiology and Diagnostic Science, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan
Institutions: National Institutes for Quantum Science and Technology (Japan); Jikei University School of Medicine (Japan); Keio University (Japan); Niigata University (Japan); Osaka Metropolitan University (Japan)
Journal: Science advances, volume 12, issue 28, article eaed0348
Dates: received 16 October 2025; accepted 22 May 2026; published online 10 July 2026; in print July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1126/sciadv.aed0348 · PMID 42430462 · PMCID PMC13353357 · OpenAlex W7167930442
Open access: gold, a free copy (OpenAlex)
Status: code verified (how the code is found and verified)
Categories: PET / SPECT (modality), human (organism), clinical / translational (subfield)
Methods: Statistics, Connectivity, fMRI & imaging, Preprocessing
MeSH: Cognition*, Supranuclear Palsy, Progressive*, tau Proteins*, Aged, Connectome, Female, Humans, Male, Middle Aged, Positron-Emission Tomography (* major topic)
Journal subjects: Neuroscience, Diseases and Disorders
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: JST (JPMJMS2024, JPMJFR220R); AMED (JP24wm0625307, JP19dm0207072, JP24wm0625001, JP25wm0625520); MEXT (JP24H00734, JP25H01767, JP23K11796, JP23H02825, 21K15705, 24K18693); Biogen Idec Inc; APRINOIA Therapeutics
Citations: not cited yet (Europe PMC); 72 references in the paper

Abstract

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with motor and cognitive impairments. Whereas motor symptoms are associated with subcortical tau deposits, the mechanisms underlying the cognitive symptoms remain unclear due to heterogeneous and primarily subcortical distribution of pathological tau deposits. Here, we combined tau-PET (tau positron emission tomography) using a high-contrast probe we developed with a normative connectome in 37 patients with PSP and 48 healthy controls. We found that tau deposition sites functionally connected to a common cortical network that could not be derived from atrophy. This network predominantly overlapped with canonical action-mode and frontoparietal networks, which support adaptive, goal-directed behavior. Whereas the extent of primary tau deposition predicted motor symptoms, the normative connectivity strength from tau deposition sites to the identified cortical network explained the severity of cognitive deficits. These findings suggest a previously unknown mechanism that cognitive, but not motor, deficits in PSP arise from remote effects of tau deposition—independent of atrophy—via convergent connectivity to a common cortical network.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above.

Zenodo 18240936

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: “Data, code, and materials availability:”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: FSL (10 files), AFNI (4 files)
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
10 files
At the source: zenodo.org/records/18240936

yukihori1/2026-hori-psp_tau

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Commit: e06dadc9718927941679bdaa26eb60b1141ea16f, 14 January 2026
Languages: Shell (10)
Size: 14 files, 10 scripts
Software Heritage: not archived
Found in: the Zenodo archive record
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: FSL (10 files), AFNI (4 files)
Availability: 1 check, the latest on 27 September 2026: the link answers
  • 27 September 2026: the link answers
10 files
At the source: github.com/YukiHori1/2026-Hori-PSP_tau/tree/v1.0.0

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 20 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data, code, and materials availability

All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. Data and code necessary to reproduce the results reported in this paper available at https://zenodo.org/records/18240936. This study did not generate new materials.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 10 MeSH terms, 5 funders, 71 references.

Cite

This paper

Hori, Y., Endo, H., Tagai, K., Kataoka, Y., Goto, R., Kurose, S., Momota, Y., Kokubo, N., Seki, C., Moriguchi, S., Shimada, H., Shinotoh, H., Tokuda, T., Takahata, K., Minamimoto, T., Higuchi, M., & Hirabayashi, T. (2026). Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy. Science advances, 12(28), eaed0348. https://doi.org/10.1126/sciadv.aed0348

BibTeX

@article{hori2026remote,
author = {Hori, Yuki and Endo, Hironobu and Tagai, Kenji and Kataoka, Yuko and Goto, Ryoji and Kurose, Shin and Momota, Yuki and Kokubo, Naomi and Seki, Chie and Moriguchi, Sho and Shimada, Hitoshi and Shinotoh, Hitoshi and Tokuda, Takahiko and Takahata, Keisuke and Minamimoto, Takafumi and Higuchi, Makoto and Hirabayashi, Toshiyuki},
title = {{Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy}},
journal = {Science advances},
year = {2026},
month = jul,
volume = {12},
number = {28},
pages = {eaed0348},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/sciadv.aed0348},
url = {https://doi.org/10.1126/sciadv.aed0348},
pmid = {42430462},
pmcid = {PMC13353357}
}

RIS

TY - JOUR
AU - Hori, Yuki
AU - Endo, Hironobu
AU - Tagai, Kenji
AU - Kataoka, Yuko
AU - Goto, Ryoji
AU - Kurose, Shin
AU - Momota, Yuki
AU - Kokubo, Naomi
AU - Seki, Chie
AU - Moriguchi, Sho
AU - Shimada, Hitoshi
AU - Shinotoh, Hitoshi
AU - Tokuda, Takahiko
AU - Takahata, Keisuke
AU - Minamimoto, Takafumi
AU - Higuchi, Makoto
AU - Hirabayashi, Toshiyuki
TI - Remote network for cognitive symptoms derived from tau accumulation in progressive supranuclear palsy
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/07/10
VL - 12
IS - 28
SP - eaed0348
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/sciadv.aed0348
UR - https://doi.org/10.1126/sciadv.aed0348
LA - en
ER -

CSL-JSON

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"container-title": "Science advances",
"author": [
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"family": "Hori",
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{
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{
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{
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{
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{
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{
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"container-title-short": "Sci Adv",
"volume": "12",
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"page": "eaed0348",
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"PMID": "42430462",
"PMCID": "PMC13353357",
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10
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