Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol.
Overview
- Department of Neurosciences, Newcastle Upon Tyne NHS Foundation Trust, Newcastle upon Tyne, UK
- Clinical Ageing Research Unit, Newcastle University, Campus for Ageing and Vitality, Newcastle upon Tyne, UK
- Translational and Clinical Research Institute, The Medical School, Newcastle University, Newcastle upon Tyne, UK
- NIHR Newcastle Biomedical Research Centre (BRC), Newcastle upon Tyne, UK
- Translational and Clinical Research Institute, Aarhus University Hospital Department of Nuclear Medicine & PET-Centre, Aarhus, Denmark
Abstract
Introduction: Deep brain stimulation (DBS) for dystonia is effective but programming optimisation can take months. Local field potentials (LFPs) recorded by the Medtronic Percept device may provide biomarkers to guide stimulation. This study will prospectively evaluate whether chronic LFP profiles correlate with clinical outcomes and can inform DBS programming strategies.
Methods and analysis: LFP-DYT is a single-centre, multi-phase observational study at Newcastle upon Tyne National Health Service (NHS) Foundation Trust. An internal pilot (Cohort 1) will refine recording workflows, followed by Cohort 2 (traditional programming with LFP recordings) and Cohort 3 (LFP-informed programming). 20–25 adults with primary dystonia undergoing globus pallidus internus DBS will be recruited. The study combines chronic LFP sensing with neurophysiology (electromyography, electroencephalography),
Ethics and dissemination: The study has NHS Research Ethics Committee approval from the East Midlands—Derby Research Ethics Committee (REC reference: 24/
Trial registration number: NCT07309133.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
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Data
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Data availability statement
No datasets have been generated or analysed for this protocol. On study completion, de-identified data and analysis code will be available from the corresponding author on reasonable request, subject to institutional and regulatory requirements. No biological specimens will be stored for future unspecified use.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 3 keywords, 14 MeSH terms, 2 funders, 40 references.
Cite
This paper
Ledingham, D., Mills, R., Gibbs, M., Maynes, M., Pal, A., Iredale, R., Foster, V., Ong, S., Sathyanarayana, S., Jenkins, A., Nicholson, C., Hussain, M., Baker, M. R., & Pavese, N. (2026). Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol. BMJ open, 16(5), e117391. https://
BibTeX
@article{ledingham2026pr
author = {Ledingham, David and Mills, Russell and Gibbs, Michelle and Maynes, Madeleine and Pal, Anubhab and Iredale, Robyn and Foster, Victoria and Ong, Stephanie and Sathyanarayana, Sahana and Jenkins, Alistair and Nicholson, Claire and Hussain, Mohammed and Baker, Mark R and Pavese, Nicola},
title = {{Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol}},
journal = {BMJ open},
year = {2026},
month = may,
volume = {16},
number = {5},
pages = {e117391},
publisher = {BMJ Publishing Group},
issn = {2044-6055},
doi = {10.1136/
url = {https://
pmid = {42097654},
pmcid = {PMC13157758}
}
RIS
TY - JOUR
AU - Ledingham, David
AU - Mills, Russell
AU - Gibbs, Michelle
AU - Maynes, Madeleine
AU - Pal, Anubhab
AU - Iredale, Robyn
AU - Foster, Victoria
AU - Ong, Stephanie
AU - Sathyanarayana, Sahana
AU - Jenkins, Alistair
AU - Nicholson, Claire
AU - Hussain, Mohammed
AU - Baker, Mark R
AU - Pavese, Nicola
TI - Prospective multi-phase observational study evaluating local field potentials to guide deep brain stimulation programming in dystonia at a UK Tertiary Neurosciences Centre (LFP-DYT): a protocol
T2 - BMJ open
J2 - BMJ Open
PY - 2026
DA - 2026/
VL - 16
IS - 5
SP - e117391
SN - 2044-6055
PB - BMJ Publishing Group
DO - 10.1136/
UR - https://
LA - en
ER -
CSL-JSON
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