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Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion.

Overview

Authors: Jingwei Zhao1,2,3,4, Jiayun Zhu1,2,3,4, Ziyi Yang1,2,3,4, Yangyang Zhai1,2,3,4, Cheng Zhao1,2,3,4, Zhichao Lu5, Danyang Shen6, Qiuyi Tang1,2,3,4, Xiaoling Song1,2,3,4, Lin Jiang1,2,3,4, Wenting Dai1,2,3,4, Yaxuan Wang7, Yidi Zhu1,2,3,4, Liuqing Shi1,2,3,4, Runfa Bao1,2,3,4, Zhimin Geng8, Ziheng Wang9, Shilei Liu1,2,3,4, Wei Gong1,2,3,4
  1. Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
  2. Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China
  3. Shanghai Research Center of Biliary Tract Disease, Shanghai, China
  4. Biliary Disease Research Institute of Shanghai Jiao Tong University School of Medicine, Shanghai, China
  5. Department of Neurosurgery, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
  6. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
  7. Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
  8. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China
  9. MOE Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China
Journal: Cancer research, volume 86, issue 6, pages 1392-1413
Dates: received 27 May 2025; accepted 17 December 2025; published online 29 December 2025; in print 16 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1158/0008-5472.can-25-2237 · PMID 41460724 · PMCID PMC13012253 · OpenAlex W7117480303
Open access: hybrid, a free copy (OpenAlex)
Status: code found, not verified yet
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
MeSH: Extracellular Vesicles*, Gallbladder Neoplasms*, Necroptosis*, Receptor-Interacting Protein Serine-Threonine Kinases*, Animals, HMGB1 Protein, Humans, Mice, Neoplasm Invasiveness, Neurons, Peripheral Nerves (* major topic)
Topic: Extracellular vesicles in disease (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Science and Technology Commission of Shanghai Municipality (23YF1426000); National Natural Science Foundation of China (NSFC) (No. 82403527, XZ2023ZR-ZY40(Z), No. 82203735, No. 82303289); Shanghai Jiao Tong University (SJTU) (YG2024QNA19); Suzhou Gusu Medical Youth Talent (No.GSWS2022026)
Citations: cited by 5 papers (Europe PMC); 52 references in the paper
Research resources: calnexin RRID:AB_10563673, CK19 RRID:AB_1523469, including CD63 RRID:AB_2800495, TSG101 RRID:AB_2943043, RRID:AB_3711368, human IL33 RRID:AB_3712870, HMGB1 RRID:AB_3712872, HSP90 RRID:AB_3712873, histones RRID:AB_3712874, S100A8/9 RRID:AB_3712875, HSP70 RRID:AB_3712876, TUJ1 RRID:AB_444319, HEK293T cells RRID:CVCL_0063, RRID:IMSR_JAX:000664, Structures were preprocessed using PyMOL RRID:SCR_000305, GraphPad Prism RRID:SCR_002798, RRID:SCR_003070, RRID:SCR_006459, RRID:SCR_014485, UCSF ChimeraX RRID:SCR_015872, ClusPro online servers RRID:SCR_018248, RRID:SCR_019091

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

codeocean:6464349

License: none: the authors keep all their rights
State: cannot be verified, verified on 30 September 2026
Evidence: found in the paper
Software Heritage: not checked
Found in: “Data Availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: cannot be verified
  • 30 September 2026: cannot be verified

codeocean.com/widget.js

License: none: the authors keep all their rights
State: unreachable at the last attempt, verified on 30 September 2026
Evidence: found in the paper
Software Heritage: not checked
Found in: “Data Availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 6 checks, the latest on 30 September 2026: unreachable at the last attempt (HTTP 403)
  • 30 September 2026: unreachable at the last attempt (HTTP 403)
  • 29 September 2026: unreachable at the last attempt (HTTP 403)
  • 28 September 2026: unreachable at the last attempt (HTTP 403)
  • 28 September 2026: unreachable at the last attempt (HTTP 403)
  • 27 September 2026: unreachable at the last attempt (HTTP 403)
  • 27 September 2026: unreachable at the last attempt (HTTP 403)

The paper's code and data availability statement is in the Data section.

Tracing map

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  • no match between paragraphs and code yet;
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1158/0008-5472.can-25-2237.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 11 MeSH terms, 4 funders, 52 references, 22 RRIDs.

Cite

This paper

Zhao, J., Zhu, J., Yang, Z., Zhai, Y., Zhao, C., Lu, Z., Shen, D., Tang, Q., Song, X., Jiang, L., Dai, W., Wang, Y., Zhu, Y., Shi, L., Bao, R., Geng, Z., Wang, Z., Liu, S., & Gong, W. (2026). Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion. Cancer research, 86(6), 1392-1413. https://doi.org/10.1158/0008-5472.can-25-2237

BibTeX

@article{zhao2026extracellular,
author = {Zhao, Jingwei and Zhu, Jiayun and Yang, Ziyi and Zhai, Yangyang and Zhao, Cheng and Lu, Zhichao and Shen, Danyang and Tang, Qiuyi and Song, Xiaoling and Jiang, Lin and Dai, Wenting and Wang, Yaxuan and Zhu, Yidi and Shi, Liuqing and Bao, Runfa and Geng, Zhimin and Wang, Ziheng and Liu, Shilei and Gong, Wei},
title = {{Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion}},
journal = {Cancer research},
year = {2026},
month = mar,
volume = {86},
number = {6},
pages = {1392--1413},
publisher = {American Association for Cancer Research},
issn = {0008-5472},
doi = {10.1158/0008-5472.can-25-2237},
url = {https://doi.org/10.1158/0008-5472.can-25-2237},
pmid = {41460724},
pmcid = {PMC13012253}
}

RIS

TY - JOUR
AU - Zhao, Jingwei
AU - Zhu, Jiayun
AU - Yang, Ziyi
AU - Zhai, Yangyang
AU - Zhao, Cheng
AU - Lu, Zhichao
AU - Shen, Danyang
AU - Tang, Qiuyi
AU - Song, Xiaoling
AU - Jiang, Lin
AU - Dai, Wenting
AU - Wang, Yaxuan
AU - Zhu, Yidi
AU - Shi, Liuqing
AU - Bao, Runfa
AU - Geng, Zhimin
AU - Wang, Ziheng
AU - Liu, Shilei
AU - Gong, Wei
TI - Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion
T2 - Cancer research
J2 - Cancer Res
PY - 2026
DA - 2026/03/01
VL - 86
IS - 6
SP - 1392
EP - 1413
SN - 0008-5472
PB - American Association for Cancer Research
DO - 10.1158/0008-5472.can-25-2237
UR - https://doi.org/10.1158/0008-5472.can-25-2237
LA - en
ER -

CSL-JSON

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