Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion.
Overview
- Department of General Surgery, Xinhua Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China
- Shanghai Research Center of Biliary Tract Disease, Shanghai, China
- Biliary Disease Research Institute of Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Department of Neurosurgery, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China
- Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China
- Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
- Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an, China
- MOE Frontier Science Centre for Precision Oncology, University of Macau, Macau SAR, China
Abstract
The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.
Code
No file of the authors' code could be read here: it is described below, and read at its source.
codeocean:6464349
Availability: 1 check, the latest on 30 September 2026: cannot be verified
- 30 September 2026: cannot be verified
codeocean.com/widget.js
Availability: 6 checks, the latest on 30 September 2026: unreachable at the last attempt (HTTP 403)
- 30 September 2026: unreachable at the last attempt (HTTP 403)
- 29 September 2026: unreachable at the last attempt (HTTP 403)
- 28 September 2026: unreachable at the last attempt (HTTP 403)
- 28 September 2026: unreachable at the last attempt (HTTP 403)
- 27 September 2026: unreachable at the last attempt (HTTP 403)
- 27 September 2026: unreachable at the last attempt (HTTP 403)
The paper's code and data availability statement is in the Data section.
Tracing map
Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.
What the map holds:
- 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
- 0 scripts, each with its path and the digest of its content;
- no match between paragraphs and code yet;
- neither the text of the paper nor the code itself.
Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.
Data
No dataset and no data link were found in the paper.
Code and data availability statement
The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:
- it points to the authors' code: codeocean.com/
widget.js , codeocean:6464349 - it says that the data are available on request
Read it in the paper: doi.org/10.1158/0008-5472.can-25-2237.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 11 MeSH terms, 4 funders, 52 references, 22 RRIDs.
Cite
This paper
Zhao, J., Zhu, J., Yang, Z., Zhai, Y., Zhao, C., Lu, Z., Shen, D., Tang, Q., Song, X., Jiang, L., Dai, W., Wang, Y., Zhu, Y., Shi, L., Bao, R., Geng, Z., Wang, Z., Liu, S., & Gong, W. (2026). Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion. Cancer research, 86(6), 1392-1413. https://
BibTeX
@article{zhao2026extrace
author = {Zhao, Jingwei and Zhu, Jiayun and Yang, Ziyi and Zhai, Yangyang and Zhao, Cheng and Lu, Zhichao and Shen, Danyang and Tang, Qiuyi and Song, Xiaoling and Jiang, Lin and Dai, Wenting and Wang, Yaxuan and Zhu, Yidi and Shi, Liuqing and Bao, Runfa and Geng, Zhimin and Wang, Ziheng and Liu, Shilei and Gong, Wei},
title = {{Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion}},
journal = {Cancer research},
year = {2026},
month = mar,
volume = {86},
number = {6},
pages = {1392--1413},
publisher = {American Association for Cancer Research},
issn = {0008-5472},
doi = {10.1158/
url = {https://
pmid = {41460724},
pmcid = {PMC13012253}
}
RIS
TY - JOUR
AU - Zhao, Jingwei
AU - Zhu, Jiayun
AU - Yang, Ziyi
AU - Zhai, Yangyang
AU - Zhao, Cheng
AU - Lu, Zhichao
AU - Shen, Danyang
AU - Tang, Qiuyi
AU - Song, Xiaoling
AU - Jiang, Lin
AU - Dai, Wenting
AU - Wang, Yaxuan
AU - Zhu, Yidi
AU - Shi, Liuqing
AU - Bao, Runfa
AU - Geng, Zhimin
AU - Wang, Ziheng
AU - Liu, Shilei
AU - Gong, Wei
TI - Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion
T2 - Cancer research
J2 - Cancer Res
PY - 2026
DA - 2026/
VL - 86
IS - 6
SP - 1392
EP - 1413
SN - 0008-5472
PB - American Association for Cancer Research
DO - 10.1158/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1158/
"type": "article-journal",
"title": "Extracellular Vesicle-Mediated O-GlcNAcase Transfer Drives Neuronal Necroptosis to Facilitate Gallbladder Cancer Perineural Invasion",
"container-title": "Cancer research",
"author": [
{
"family": "Zhao",
"given": "Jingwei"
},
{
"family": "Zhu",
"given": "Jiayun"
},
{
"family": "Yang",
"given": "Ziyi"
},
{
"family": "Zhai",
"given": "Yangyang"
},
{
"family": "Zhao",
"given": "Cheng"
},
{
"family": "Lu",
"given": "Zhichao"
},
{
"family": "Shen",
"given": "Danyang"
},
{
"family": "Tang",
"given": "Qiuyi"
},
{
"family": "Song",
"given": "Xiaoling"
},
{
"family": "Jiang",
"given": "Lin"
},
{
"family": "Dai",
"given": "Wenting"
},
{
"family": "Wang",
"given": "Yaxuan"
},
{
"family": "Zhu",
"given": "Yidi"
},
{
"family": "Shi",
"given": "Liuqing"
},
{
"family": "Bao",
"given": "Runfa"
},
{
"family": "Geng",
"given": "Zhimin"
},
{
"family": "Wang",
"given": "Ziheng"
},
{
"family": "Liu",
"given": "Shilei"
},
{
"family": "Gong",
"given": "Wei"
}
],
"container-title-short":
"volume": "86",
"issue": "6",
"page": "1392-1413",
"DOI": "10.1158/
"PMID": "41460724",
"PMCID": "PMC13012253",
"ISSN": "0008-5472",
"publisher": "American Association for Cancer Research",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
1
]
]
}
}
The tracing map gets a citation of its own once an author has validated it and it has a DOI.
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1172/jci196112
- Aging-dependent microglial heterogeneity worsens outcomes in models of traumatic brain injury.Journal: The Journal of clinical investigationIn common: mouse, 2 authors
- [2] doi:10.1038/s41467-026-72932-5
- Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer.Journal: Nature communicationsIn common: other condition, mouse, cellular / molecular, 2 references
- [3] doi:10.1186/s13020-026-01445-6
- Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/
Hippo signaling. Journal: Chinese medicineIn common: other condition, mouse, cellular / molecular, 2 references - [4] doi:10.1016/j.celrep.2026.117314
- GLIS3 marks a neural-like progenitor cell state that drives metastasis in pancreatic ductal adenocarcinoma.Journal: Cell reportsIn common: other condition, mouse, cellular / molecular, 1 reference
- [5] doi:10.1016/j.xcrm.2026.102994
- Targeting of tripartite neuron-cancer-immune cell crosstalk augments response to chemotherapy and immunotherapy.Journal: Cell reports. MedicineIn common: other condition, mouse, cellular / molecular, 1 reference
- [6] doi:10.1093/brain/awaf360
- MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.Journal: Brain : a journal of neurologyIn common: other condition, mouse, cellular / molecular, 1 reference
- [7] doi:10.1186/s12935-026-04243-0
- LIS1 mediated Schwann cell reprogramming enhances perineural invasion by activating the serine/
NMDAR/ AKT signaling pathway in head and neck squamous carcinoma. Journal: Cancer cell internationalIn common: other condition, mouse, cellular / molecular, 1 reference - [8] doi:10.1038/s44321-026-00473-x
- OTUB1 non-canonically inhibits TAB2 ubiquitination to govern microglia-mediated neuroinflammation.Journal: EMBO molecular medicineIn common: mouse, cellular / molecular, 1 reference
- [9] doi:10.1038/s41419-026-08862-3
- O-GlcNAcylation reprograms microglial inflammatory states and attenuates Alzheimer's disease pathology.Journal: Cell death & diseaseIn common: mouse, cellular / molecular, 1 reference
- [10] doi:10.1016/j.stemcr.2026.103020
- Brain corticogenesis promotes SARS-CoV-2 neuro-glial tropism through lipid-dependent viral replication.Journal: Stem cell reportsIn common: other condition, cellular / molecular, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Validate its tracing map
You validate the map as this page shows it: 2 repositories of the authors' code, each at its verified commit and with its license, 0 scripts, and 0 matches between paragraphs and code (see the Code and Map sections). It then receives a DOI on Zenodo, with you (your ORCID iD) and OSCR as its creators; the code itself is not deposited.
The map's fingerprint: sha256:2d9e7ba91a758bf2…
Add the badge to its README
The badge links the code to this page. Copy one of these into the README of the paper's code: only you decide where it goes, and nothing is changed for you.
Markdown
[.
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.
