Early Metabolic Alterations Are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants.
Overview
- Pediatric Neurology and Development Center, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel, affiliated to the Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
- Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel
- Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
- Women and Children’s Health Research Unit, Gertner Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel
- National Newborn Screening Program, Public Health Services, Ministry of Health, Jerusalem, Israel
- Blavatnik School of Computer Science, Tel Aviv University, Tel Aviv, Israel
- Department of Neonatology, Shamir Medical Center (Assaf Harofeh), Zerifin, Israel, affiliated to the Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
- School of Public Health, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel
Abstract
Introduction: The aim of this study was to identify early metabolic alterations associated with intraventricular hemorrhage (IVH) and its complications, periventricular hemorrhagic infarction (PVHI), and post-hemorrhagic ventricular dilatation (PHVD), in very preterm infants.
Methods: This population-based observational cohort included 7,313 preterm infants born at 24–32 weeks’ gestation between 2009 and 2019. Twenty-one analytes were quantified from dried blood samples collected within the first 96 h of life using tandem mass spectrometry. Multivariable logistic regression models were used to examine the association between analyte concentration quartiles and IVH, including analysis stratified by IVH-related complications.
Results: IVH was diagnosed in 882 infants, while 6,431 had normal neurosonography. Compared with infants in the lowest quartile, those in the highest quartile of methionine and proline concentrations had increased odds of IVH (odds ratio [OR] 1.50, 95% confidence interval [CI] 1.21–1.86 and OR 1.74, 95% CI: 1.40–2.17, respectively). In contrast, infants in the highest quartile of free carnitine concentrations had significantly lower odds of IVH (OR 0.53, 95% CI: 0.42–0.67). These associations were more pronounced among infants with PVHI (n = 149) and PHVD (n = 152) (p < 0.001).
Conclusion: Among very preterm infants, higher methionine and proline concentrations within the first 96 h of life were associated with increased risks of IVH and its complications, whereas higher free carnitine concentrations were associated with lower risks. Whether these metabolic alterations reflect secondary responses to ischemic–hemorrhagic brain injury or act as modulators of germinal matrix vulnerability warrants further investigation.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
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Data
Datasets cited
- figshare:32614125, at figshare; found in DataCite
Data Availability Statement
Data are not available for public access because all NICUs participating in national VLBW infant database Neonatal Network signed an agreement that does not allow data sharing. Further inquiries can be directed to the corresponding author.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Publisher: n/a → Karger Publishers
- Authors: added Haim Bassan (0000-0003-1627-8069); removed Haim Bassan
- Funding: added Tel Aviv University
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, pages, dates, 10 authors, 5 keywords, 23 references.
Cite
This paper
Schupper, A., Reichman, B., Zaslavsky-Paltiel, I., Almashanu, S., Sagiv, N., Coster, D., Morag, I., Lerner-Geva, L., Bassan, H., & in collaboration with the Israel Neonatal Network. (2026). Early Metabolic Alterations Are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants. Neonatology, 1-11. https://
BibTeX
@article{schupper2026ear
author = {Schupper, Aviv and Reichman, Brian and Zaslavsky-Paltiel, Inna and Almashanu, Shlomo and Sagiv, Nadav and Coster, Dan and Morag, Iris and Lerner-Geva, Liat and Bassan, Haim and {in collaboration with the Israel Neonatal Network}},
title = {{Early Metabolic Alterations Are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants}},
journal = {Neonatology},
year = {2026},
month = jun,
pages = {1--11},
publisher = {Karger Publishers},
issn = {1661-7800},
doi = {10.1159/
url = {https://
pmid = {42263039},
pmcid = {PMC13341091}
}
RIS
TY - JOUR
AU - Schupper, Aviv
AU - Reichman, Brian
AU - Zaslavsky-Paltiel, Inna
AU - Almashanu, Shlomo
AU - Sagiv, Nadav
AU - Coster, Dan
AU - Morag, Iris
AU - Lerner-Geva, Liat
AU - Bassan, Haim
AU - in collaboration with the Israel Neonatal Network
TI - Early Metabolic Alterations Are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants
T2 - Neonatology
J2 - Neonatology
PY - 2026
DA - 2026/
SP - 1
EP - 11
SN - 1661-7800
PB - Karger Publishers
DO - 10.1159/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "Neonatology",
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