OSCR

Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes.

Overview

Authors: Yijie He1, Tao Zhang2, Ping Zhu1, Shan Gao1, Shiyang Wu1, Fengzhen Liu1, Yan Chen3, Yingshui Yao3, Guiyou Liu1,3,4,5
ORCID iDs: Yijie He, Tao Zhang, Yan Chen, Guiyou Liu
  1. Laboratory of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Ministry of Science and Technology, National Engineering Center of Internet Medical Diagnosis and Treatment Technology, Xuanwu Hospital, Laboratory of Cerebral Small Vessel Disease and Osteoporosis (Abnormal Bone Metabolism), Capital Medical University, Beijing, China
  2. Department of Intensive Care Unit, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Tianjin Huanhu Hospital, Tianjin, China
  3. Department of Epidemiology and Biostatistics, School of Public Health, Wannan Medical College, Wuhu, Anhui, China
  4. Dongying Branch Center of Collaborative Innovation Center for Brain Disorders, Shengli Oilfield Central Hospital, Dongying, Shandong, China
  5. Clinical Medicine Translational Research Institute, Chengdu Fifth People’s Hospital, Geriatric Diseases Institute of Chengdu, The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China
Institutions: Capital Medical University (China); Tianjin Huanhu Hospital (China); Wannan Medical College (China); Shengli Oilfield Central Hospital (China); Chengdu University of Traditional Chinese Medicine (China)
Journal: Journal of the American Heart Association, volume 15, issue 9, article e046208
Dates: received 11 September 2025; accepted 4 February 2026; published online 20 April 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1161/jaha.125.046208 · PMID 42003665 · PMCID PMC13279166 · OpenAlex W7154966702
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: expression quantitative trait loci, genome‐wide association studies, Mendelian randomization, single‐cell analysis, stroke, Genetics
MeSH: Genetic Predisposition to Disease*, Genome-Wide Association Study*, Quantitative Trait Loci*, Stroke*, Animals, Humans, Mendelian Randomization Analysis, Mice, Phenotype, Single-Cell Analysis, Single-Cell Gene Expression Analysis (* major topic)
Topic: Single-cell and spatial transcriptomics (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Citations: cited by 1 paper (Europe PMC); 49 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1161/jaha.125.046208.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 11 MeSH terms, 49 references.

Cite

This paper

He, Y., Zhang, T., Zhu, P., Gao, S., Wu, S., Liu, F., Chen, Y., Yao, Y., & Liu, G. (2026). Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes. Journal of the American Heart Association, 15(9), e046208. https://doi.org/10.1161/jaha.125.046208

BibTeX

@article{he2026integration,
author = {He, Yijie and Zhang, Tao and Zhu, Ping and Gao, Shan and Wu, Shiyang and Liu, Fengzhen and Chen, Yan and Yao, Yingshui and Liu, Guiyou},
title = {{Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes}},
journal = {Journal of the American Heart Association},
year = {2026},
month = apr,
volume = {15},
number = {9},
pages = {e046208},
publisher = {Wiley},
issn = {2047-9980},
doi = {10.1161/jaha.125.046208},
url = {https://doi.org/10.1161/jaha.125.046208},
pmid = {42003665},
pmcid = {PMC13279166}
}

RIS

TY - JOUR
AU - He, Yijie
AU - Zhang, Tao
AU - Zhu, Ping
AU - Gao, Shan
AU - Wu, Shiyang
AU - Liu, Fengzhen
AU - Chen, Yan
AU - Yao, Yingshui
AU - Liu, Guiyou
TI - Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes
T2 - Journal of the American Heart Association
J2 - J Am Heart Assoc
PY - 2026
DA - 2026/04/20
VL - 15
IS - 9
SP - e046208
SN - 2047-9980
PB - Wiley
DO - 10.1161/jaha.125.046208
UR - https://doi.org/10.1161/jaha.125.046208
LA - en
ER -

CSL-JSON

{
"id": "10.1161/jaha.125.046208",
"type": "article-journal",
"title": "Integration of Genome-Wide Association Studies With Single-Cell and Bulk Expression Quantitative Trait Locus to Identify Stroke Susceptibility Genes",
"container-title": "Journal of the American Heart Association",
"author": [
{
"family": "He",
"given": "Yijie"
},
{
"family": "Zhang",
"given": "Tao"
},
{
"family": "Zhu",
"given": "Ping"
},
{
"family": "Gao",
"given": "Shan"
},
{
"family": "Wu",
"given": "Shiyang"
},
{
"family": "Liu",
"given": "Fengzhen"
},
{
"family": "Chen",
"given": "Yan"
},
{
"family": "Yao",
"given": "Yingshui"
},
{
"family": "Liu",
"given": "Guiyou"
}
],
"container-title-short": "J Am Heart Assoc",
"volume": "15",
"issue": "9",
"page": "e046208",
"DOI": "10.1161/jaha.125.046208",
"PMID": "42003665",
"PMCID": "PMC13279166",
"ISSN": "2047-9980",
"publisher": "Wiley",
"URL": "https://doi.org/10.1161/jaha.125.046208",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
20
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1097/md.0000000000048634
Identifying therapeutic target genes for stroke through systematic druggable Mendelian randomization analysis.
Journal: Medicine
In common: stroke, genetics / omics, cellular / molecular, 7 references
[2] doi:10.1002/alz.71552
APOE*4 risk-modifying genes and drug targets in Alzheimer's disease through cell-type-specific genomic analyses.
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association
In common: DOI 10.7303/syn52335732, genetics / omics, cellular / molecular, 3 references
[3] doi:10.1371/journal.pcbi.1014422 [code]
Deciphering cell type-specific causal genetic effects on brain imaging-derived phenotypes and disorders with single-cell Mendelian randomization.
Journal: PLoS computational biology
In common: genetics / omics, cellular / molecular, 7 references
[4] doi:10.1161/jaha.125.046088 [code]
Systematic Identification of Therapeutic Targets and Repurposed Drugs for Stroke: From Genome Causal Analysis to Multilevel Validation.
Journal: Journal of the American Heart Association
In common: stroke, genetics / omics, mouse, 4 references
[5] doi:10.1038/s41467-026-73007-1 [code]
Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states.
Journal: Nature communications
In common: DOI 10.7303/syn52335732, genetics / omics, cellular / molecular, 1 reference
[6] doi:10.1038/s43587-026-01106-1 [code]
Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization.
Journal: Nature aging
In common: stroke, genetics / omics, 4 references
[7] doi:10.1186/s12974-026-03885-1 [code]
Shared transcriptomic signatures in perilesional and contralesional cortex after ischemic stroke.
Journal: Journal of neuroinflammation
In common: stroke, genetics / omics, mouse, 1 other category, 3 references
[8] doi:10.3390/genes17080874 [code]
Multi-Omic Analysis of Cerebrospinal Fluid Metabolites in Autism Spectrum Disorder: Biomarker Identification, Metabolic Genetics Insights, and Network Toxicology.
Journal: Genes
In common: genetics / omics, 4 references
[9] doi:10.3389/ebm.2026.10948
Genetic evidence for causal relationships between brain functional networks and domain-specific recovery after nondisabling ischemic stroke.
Journal: Experimental biology and medicine (Maywood, N.J.)
In common: stroke, genetics / omics, 3 references
[10] doi:10.64898/2026.08.12.26360241
Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease
Journal: medRxiv (preprint)
In common: stroke, genetics / omics, cellular / molecular, 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.