Unveiling Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases Through Integrated Bioinformatics Approaches.

Overview

1. Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland

Abstract

Carbonic anhydrases are metalloenzymes found both in vertebrates and invertebrates. The CAs catalyze the reversible hydration of CO2 to bicarbonate and H+ ions and play a significant role in respiration, transport of CO2, pH homeostasis, electrolyte secretion, and biosynthetic reactions. The enzymatic activity of CAs is due to the coordination of Zn2+ in the active site by three histidine residues; however, in humans, there are three CAs known as CA-related proteins (CARPs) that are catalytically inactive due to the absence of one or more of the three histidine residues required for the coordination of the Zn2+ in the active site. Studies have shown that CARPs are expressed in all parts of the brain and are overexpressed in some cancers suggesting that the CARPs play a crucial role in neurological disorders and the development of cancer. However, the precise physiological roles of CARPs are still an enigma. In this study, we present a comprehensive biological workflow that employs various machine learning methodologies and statistical procedures to assess the similarity across CARPs by evaluating shared biological parameters. This approach enabled us to identify potential biomarkers, including transcription factors, co-expressed genes, and phenotypes, that may influence the expression of CARPs within disease pathways. Furthermore, we proposed a computational human health model by analyzing drugs and chemical candidates to prioritize compounds that may modulate regulatory networks associated with CARPs. These computational analyses identified candidate compounds for future experimental investigation in the context of neurological disorders and cancer.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

• 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
• 0 scripts, each with its path and the digest of its content;
• no match between paragraphs and code yet;
• neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data Availability Statement

The datasets used to develop the workflow for this manuscript, along with the Python script and obtained results, are provided in the following Zenodo repository: https://zenodo.org/records/12796528.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 3 authors, 8 keywords, 30 references.

Cite

This paper

Bhowmik, R., Ray, R., & Aspatwar, A. (2026). Unveiling Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases Through Integrated Bioinformatics Approaches. Bioinformatics and biology insights, 20, 11779322261475822. https://doi.org/10.1177/11779322261475822

The tracing map gets a citation of its own once an author has validated it and it has a DOI.

Similar papers

No other paper with a page shares enough with this one yet: tools, categories, datasets, references or authors.

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.