Astrocyte autophagy-pyroptosis crosstalk in Alzheimer's: insights from knowledge graphs.

Overview

1. Department of Central Laboratory, Pudong Gongli Hospital, Shanghai University of Medicine & Health Sciences, No. 219 Miaopu Road, Shanghai, 200135 China
2. Clinical Research Center for Mental Disorders, Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, No. 165 Sanlin Road, Shanghai, 200124 China

Abstract

Astrocytes play a crucial role in brain health and are implicated in various aspects of Alzheimer’s disease (AD) progression. However, the mechanism underlying astrocyte autophagy and pyroptosis in AD remains unclear. To advance this knowledge, we constructed a knowledge graph of AD and dementia (AdDKG) by integrating literature-derived data with the Systematized Nomenclature of Medicine – Clinical Terms (SNOMED CT). The core knowledge base, addkg, was created through named entity recognition and semantic annotation of 172 283 articles using a concept identifier (CI-er) tool. AdDKG knowledge graph extends addkg knowledge base by incorporating SNOMED CT to standardize entities and enrich their relations and attributes. To validate the usefulness of AdDKG, we designed a case study to investigate the roles of astrocyte autophagy and pyroptosis in AD. The query results demonstrated that AdDKG precisely retrieves and prioritizes highly relevant articles, enabling focused investigation of mechanistic relations that would otherwise require extensive manual curation. Further detailed analysis revealed that abnormal autophagy, pyroptosis-induced inflammation, and their interplay are pivotal in AD progression. These findings highlight the utility and efficiency of AdDKG as a research tool for AD research, through which we elucidated the autophagy-pyroptosis interaction in astrocytes as a critical AD mechanism.

Supplementary Information: The online version contains supplementary material available at 10.1186/s12883-026-04793-w.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

• figshare:32195353, at figshare; found in DataCite

Data availability

The datasets used and analyzed during this study are available from the corresponding author upon reasonable request.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 5 keywords, 6 MeSH terms, 2 funders, 45 references.

Cite

This paper

Liu, T., Huang, Z., & Qin, H. (2026). Astrocyte autophagy-pyroptosis crosstalk in Alzheimer's: insights from knowledge graphs. BMC neurology, 26(1), 305. https://doi.org/10.1186/s12883-026-04793-w

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