OSCR

White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss.

Overview

Authors: Jeryn Chang1,2, Harry Lipscombe1,2, Jinglei Lv3,4, Pamela A. McCombe2,5,6,7, Robert D. Henderson2,5,6,7, Shyuan T. Ngo2,5,6,7,8, Frederik J. Steyn1,2,5,7, Thomas B. Shaw2,5,9,10
ORCID iDs: Thomas B. Shaw
  1. School of Biomedical Sciences, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland,Brisbane, Queensland Australia
  2. University of Queensland Centre for Motor Neuron Disease Research, The University of Queensland,Brisbane, Australia
  3. Sydney Medical School & School of Biomedical Engineering, The University of Sydney,Sydney, Australia
  4. Brain and Mind Centre, The University of Sydney,Sydney, Australia
  5. Department of Neurology, Royal Brisbane and Women’s Hospital,Brisbane, Australia
  6. UQ Centre for Clinical Research, The University of Queensland,Brisbane, Australia
  7. Wesley Medical Research, The Wesley Hospital,Brisbane, Australia
  8. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland,Brisbane, Australia
  9. School of Electrical Engineering and Computer Science, The University of Queensland,Brisbane, Queensland Australia
  10. Centre for Advanced Imaging, The Australian Institute for Bioengineering and Nanotechnology, The University of Queensland,Brisbane, Australia
Institutions: The University of Queensland (Australia); The University of Sydney (Australia); Royal Brisbane and Women's Hospital (Australia); Wesley Hospital (Australia)
Journal: BMC medicine, volume 24, issue 1, article 295
Dates: received 9 October 2025; accepted 26 February 2026; published online 27 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12916-026-04763-6 · PMID 41896845 · PMCID PMC13147748 · OpenAlex W7141354857
Open access: gold, a free copy (OpenAlex)
Status: empty repository (how the code is found and verified)
Categories: structural MRI / diffusion (modality), human (organism), other condition (population), clinical / translational (subfield)
Methods: Statistics, fMRI & imaging, Preprocessing
Keywords: Appetite loss, Diffusion MRI, White matter, Fixel-based analysis, Non-motor symptoms
MeSH: Amyotrophic Lateral Sclerosis*, Reward*, White Matter*, Aged, Appetite, Case-Control Studies, Female, Humans, Male, Middle Aged (* major topic)
Topic: Amyotrophic Lateral Sclerosis Research (Clinical Neurology, Medicine), according to OpenAlex
Funding: University of Queensland (UQ Graduate School Scholarship (RTP), Scott Sullivan MND Research Fellowship, Faculty of Medicine); MND Research Australia (TU2201, PDF2112); Royal Brisbane and Women's Hospital Foundation (Scott Sullivan MND Research Fellowship); MND and Me Foundation (Scott Sullivan MND Research Fellowship); FightMND (Scott Sullivan MND Research Fellowship, Collaborative Initiative Grant); Wesley Medical Research (2017-07); Department of Health | National Health and Medical Research Council (NHMRC) (APP2029871)
Citations: cited by 1 paper (Europe PMC); 79 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

figshare 30511307

License: CC-BY-4.0
State: the link answers, verified on 30 September 2026
Evidence: files inventoried
Size: 1 file, 0 scripts
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers (HTTP 200)
  • 30 September 2026: the link answers (HTTP 200)
At the source:

The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

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Read it in the paper: doi.org/10.1186/s12916-026-04763-6.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 10 MeSH terms, 7 funders, 76 references.

Cite

This paper

Chang, J., Lipscombe, H., Lv, J., McCombe, P. A., Henderson, R. D., Ngo, S. T., Steyn, F. J., & Shaw, T. B. (2026). White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss. BMC medicine, 24(1), 295. https://doi.org/10.1186/s12916-026-04763-6

BibTeX

@article{chang2026white,
author = {Chang, Jeryn and Lipscombe, Harry and Lv, Jinglei and McCombe, Pamela A. and Henderson, Robert D. and Ngo, Shyuan T. and Steyn, Frederik J. and Shaw, Thomas B.},
title = {{White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss}},
journal = {BMC medicine},
year = {2026},
month = mar,
volume = {24},
number = {1},
pages = {295},
publisher = {BMC},
issn = {1741-7015},
doi = {10.1186/s12916-026-04763-6},
url = {https://doi.org/10.1186/s12916-026-04763-6},
pmid = {41896845},
pmcid = {PMC13147748}
}

RIS

TY - JOUR
AU - Chang, Jeryn
AU - Lipscombe, Harry
AU - Lv, Jinglei
AU - McCombe, Pamela A.
AU - Henderson, Robert D.
AU - Ngo, Shyuan T.
AU - Steyn, Frederik J.
AU - Shaw, Thomas B.
TI - White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss
T2 - BMC medicine
J2 - BMC Med
PY - 2026
DA - 2026/03/27
VL - 24
IS - 1
SP - 295
SN - 1741-7015
PB - BMC
DO - 10.1186/s12916-026-04763-6
UR - https://doi.org/10.1186/s12916-026-04763-6
LA - en
ER -

CSL-JSON

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"author": [
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"family": "Chang",
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"container-title-short": "BMC Med",
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"page": "295",
"DOI": "10.1186/s12916-026-04763-6",
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"PMCID": "PMC13147748",
"ISSN": "1741-7015",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12916-026-04763-6",
"language": "en",
"issued": {
"date-parts": [
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2026,
3,
27
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