OSCR

A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress.

Overview

Authors: Marisol I. Dothard1,2,3, Mariaelena Caboni4, Daniel Norment4, Nolan Sigmund3, Sarah M. Allard1,3, Jack A. Gilbert1,2,3, Ekaterina Gavrish4, Gabriel Al-Ghalith4, Andre Der-Avakian5, Philip Strandwitz4
ORCID iDs: Mariaelena Caboni, Ekaterina Gavrish
  1. Scripps Institution of Oceanography, University of California San Diego,La Jolla, CA 92093 USA
  2. Biomedical Sciences Graduate Program, University of California San Diego,La Jolla, CA 92093 USA
  3. Department of Pediatrics, University of California San Diego,La Jolla, CA 92093 USA
  4. Holobiome, 650 Albany Street, Boston, MA 02118 USA
  5. Department of Psychiatry, University of California San Diego,La Jolla, CA 92093 USA
Institutions: Scripps Institution of Oceanography (United States); University of California San Diego (United States)
Journal: BMC medicine, volume 24, issue 1, article 253
Dates: received 21 August 2025; accepted 6 March 2026; published online 10 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12916-026-04787-y · PMID 41808137 · PMCID PMC13088394 · OpenAlex W7134928886
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), rat (organism), depression (population), systems (subfield)
Methods: Spectral & time-frequency, Statistics, Smoothing, state filtering, decompositions
Keywords: Gut-brain axis, Depression, Probiotic, Postbiotic, Microbiome
MeSH: Bacteroides*, Depression*, Probiotics*, Social Defeat*, Stress, Psychological*, Animals, Behavior, Animal, Disease Models, Animal, Feces, Gastrointestinal Microbiome, Humans, Male, Prefrontal Cortex, Rats, Rats, Sprague-Dawley (* major topic)
Topic: Vagus Nerve Stimulation Research (Neurology, Neuroscience), according to OpenAlex
Funding: National Institute of Health Small Business Innovation Research (R44DK120181); NSF | National Science Foundation Graduate Research Fellowship Program (GRFP) (DGE-2038238); Translational Research Institute for Space Health - Space Health Ingress Program (NASA) (NNX16AO69A)
Citations: cited by 1 paper (Europe PMC); 146 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12916-026-04787-y.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 keywords, 15 MeSH terms, 3 funders, 144 references.

Cite

This paper

Dothard, M. I., Caboni, M., Norment, D., Sigmund, N., Allard, S. M., Gilbert, J. A., Gavrish, E., Al-Ghalith, G., Der-Avakian, A., & Strandwitz, P. (2026). A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress. BMC medicine, 24(1), 253. https://doi.org/10.1186/s12916-026-04787-y

BibTeX

@article{dothard2026human,
author = {Dothard, Marisol I. and Caboni, Mariaelena and Norment, Daniel and Sigmund, Nolan and Allard, Sarah M. and Gilbert, Jack A. and Gavrish, Ekaterina and Al-Ghalith, Gabriel and Der-Avakian, Andre and Strandwitz, Philip},
title = {{A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress}},
journal = {BMC medicine},
year = {2026},
month = mar,
volume = {24},
number = {1},
pages = {253},
publisher = {BioMed Central},
issn = {1741-7015},
doi = {10.1186/s12916-026-04787-y},
url = {https://doi.org/10.1186/s12916-026-04787-y},
pmid = {41808137},
pmcid = {PMC13088394}
}

RIS

TY - JOUR
AU - Dothard, Marisol I.
AU - Caboni, Mariaelena
AU - Norment, Daniel
AU - Sigmund, Nolan
AU - Allard, Sarah M.
AU - Gilbert, Jack A.
AU - Gavrish, Ekaterina
AU - Al-Ghalith, Gabriel
AU - Der-Avakian, Andre
AU - Strandwitz, Philip
TI - A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress
T2 - BMC medicine
J2 - BMC Med
PY - 2026
DA - 2026/03/10
VL - 24
IS - 1
SP - 253
SN - 1741-7015
PB - BioMed Central
DO - 10.1186/s12916-026-04787-y
UR - https://doi.org/10.1186/s12916-026-04787-y
LA - en
ER -

CSL-JSON

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