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From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B.

Overview

Authors: Xianwen Cao1, Yuansheng Fan1, Jiaying Wang2, Kun Wang1, Xuhan Wang1, Xiaodong Cao3, Da Zong4, Junfei Shao1
  1. Department of Neurosurgery, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No. 299 Qing Yang Road, Wuxi, 214023 Jiangsu China
  2. GCP Office, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No. 299 Qing Yang Road, Wuxi, 214023 Jiangsu China
  3. Nursing Department, Wuxi People’s Hospital Affiliated to Nanjing Medical University, No. 299 Qing Yang Road, Wuxi, 214023 Jiangsu China
  4. Department of Neurosurgery, The Affiliated Yixing Hospital of Jiangsu University, Xinjie Street, Yixing, 214200 Jiangsu China
Institutions: Wuxi People's Hospital (China); Nanjing Medical University (China); Jiangsu University (China)
Journal: Cancer cell international, volume 26, issue 1, article 291
Dates: received 25 November 2025; accepted 13 May 2026; published online 13 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12935-026-04341-z · PMID 42288839 · PMCID PMC13487985 · OpenAlex W7164643714
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Glioblastoma multiforme, Hypoxia, Lactate metabolism, PPBP, Oenothein B
Topic: Cancer, Hypoxia, and Metabolism (Cancer Research, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: the General Project of the Wuxi Medical Center, Nanjing Medical University (WMCG202402); the Wuxi Taihu Lake Talent Plan - Supports for Leading Talents in Medical and Health Profession (2020THRC-DJ-SNW); the Key Project of the Jiangsu Provincial Health Commission (ZD2022038)
Citations: not cited yet (Europe PMC); 47 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1186/s12935-026-04341-z.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 3 funders, 47 references.

Cite

This paper

Cao, X., Fan, Y., Wang, J., Wang, K., Wang, X., Cao, X., Zong, D., & Shao, J. (2026). From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B. Cancer cell international, 26(1), 291. https://doi.org/10.1186/s12935-026-04341-z

BibTeX

@article{cao2026bioinformatics,
author = {Cao, Xianwen and Fan, Yuansheng and Wang, Jiaying and Wang, Kun and Wang, Xuhan and Cao, Xiaodong and Zong, Da and Shao, Junfei},
title = {{From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B}},
journal = {Cancer cell international},
year = {2026},
month = jun,
volume = {26},
number = {1},
pages = {291},
publisher = {BMC},
issn = {1475-2867},
doi = {10.1186/s12935-026-04341-z},
url = {https://doi.org/10.1186/s12935-026-04341-z},
pmid = {42288839},
pmcid = {PMC13487985}
}

RIS

TY - JOUR
AU - Cao, Xianwen
AU - Fan, Yuansheng
AU - Wang, Jiaying
AU - Wang, Kun
AU - Wang, Xuhan
AU - Cao, Xiaodong
AU - Zong, Da
AU - Shao, Junfei
TI - From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B
T2 - Cancer cell international
J2 - Cancer Cell Int
PY - 2026
DA - 2026/06/13
VL - 26
IS - 1
SP - 291
SN - 1475-2867
PB - BMC
DO - 10.1186/s12935-026-04341-z
UR - https://doi.org/10.1186/s12935-026-04341-z
LA - en
ER -

CSL-JSON

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"type": "article-journal",
"title": "From bioinformatics to bedside: PPBP drives glioblastoma progression under hypoxia via CXCR2/PI3K/Akt signaling and is targetable by Oenothein B",
"container-title": "Cancer cell international",
"author": [
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"family": "Cao",
"given": "Xianwen"
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"container-title-short": "Cancer Cell Int",
"volume": "26",
"issue": "1",
"page": "291",
"DOI": "10.1186/s12935-026-04341-z",
"PMID": "42288839",
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"ISSN": "1475-2867",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12935-026-04341-z",
"language": "en",
"issued": {
"date-parts": [
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}
}

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