OSCR

Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma.

Overview

Authors: Jingdan Pang1, Wentian Wu2, Peiwen Zhu1, Shilan Luo1, Yanghai Xiong1, Xiesong Luo1, Sheng Chen2, Qianwen Cheng2, Yingying Du2, Xiaomei Gong1
  1. Department of Radiation Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine,507 Zhengmin Road, 200082 Shanghai, China
  2. Department of Oncology, The First Affiliated Hospital of Anhui Medical University,218 Jixi Road, 230022 Hefei, China
Journal: Cancer cell international, volume 26, issue 1, article 313
Dates: received 6 November 2025; accepted 3 June 2026; published online 13 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12935-026-04370-8 · PMID 42443906 · PMCID PMC13579860 · OpenAlex W7168176922
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), histology / microscopy (modality), human (organism), mouse (organism), other condition (population)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, Spectral & time-frequency
Keywords: Lung cancer with brain metastasis, Single-cell RNA sequencing, Gene signature, Machine learning, Therapeutic vulnerability
Topic: Single-cell and spatial transcriptomics (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Scientific Research Fund of Anhui Medical University (2022xkj165); Bethune Charitable Foundation (BFC-QYWL-QL-20240904-10); National Natural Science Foundation of China (National Science Foundation of China) (82473378); Tongji University Medicine-X Interdisciplinary Research Initiative (TJ-FK-YXJC022); Shanghai Pulmonary Hospital Research-Oriented Physician Talent Program (LYRC202407); Shanghai Municipal Health Commission Seed Funding Program for Research and Translation of New Medical Technologies (2025ZZ2011)
Citations: not cited yet (Europe PMC); 68 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Data links

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI

Read it in the paper: doi.org/10.1186/s12935-026-04370-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 keywords, 6 funders, 68 references.

Cite

This paper

Pang, J., Wu, W., Zhu, P., Luo, S., Xiong, Y., Luo, X., Chen, S., Cheng, Q., Du, Y., & Gong, X. (2026). Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma. Cancer cell international, 26(1), 313. https://doi.org/10.1186/s12935-026-04370-8

BibTeX

@article{pang2026machine,
author = {Pang, Jingdan and Wu, Wentian and Zhu, Peiwen and Luo, Shilan and Xiong, Yanghai and Luo, Xiesong and Chen, Sheng and Cheng, Qianwen and Du, Yingying and Gong, Xiaomei},
title = {{Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma}},
journal = {Cancer cell international},
year = {2026},
month = jul,
volume = {26},
number = {1},
pages = {313},
publisher = {BMC},
issn = {1475-2867},
doi = {10.1186/s12935-026-04370-8},
url = {https://doi.org/10.1186/s12935-026-04370-8},
pmid = {42443906},
pmcid = {PMC13579860}
}

RIS

TY - JOUR
AU - Pang, Jingdan
AU - Wu, Wentian
AU - Zhu, Peiwen
AU - Luo, Shilan
AU - Xiong, Yanghai
AU - Luo, Xiesong
AU - Chen, Sheng
AU - Cheng, Qianwen
AU - Du, Yingying
AU - Gong, Xiaomei
TI - Machine learning-based prognostic model and single-cell transcriptomic integration for identifying brain metastasis-associated malignant subpopulations and potential therapeutic targets in lung adenocarcinoma
T2 - Cancer cell international
J2 - Cancer Cell Int
PY - 2026
DA - 2026/07/13
VL - 26
IS - 1
SP - 313
SN - 1475-2867
PB - BMC
DO - 10.1186/s12935-026-04370-8
UR - https://doi.org/10.1186/s12935-026-04370-8
LA - en
ER -

CSL-JSON

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"container-title": "Cancer cell international",
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"DOI": "10.1186/s12935-026-04370-8",
"PMID": "42443906",
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"ISSN": "1475-2867",
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"language": "en",
"issued": {
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