Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease.
Overview
- The Second Clinical College, Guangzhou University of Chinese Medicine, Chinese Medicine Guangdong Laboratory,Guangzhou, China
- State Key Laboratory of Traditional Chinese Medicine Syndrome, Guangzhou, China
- School of Pharmaceutical Sciences, Zhejiang Chinese Medical University,Hangzhou, China
- Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University,Macao, China
- College of Pharmacy, Shaanxi University of Chinese Medicine,Xianyang, China
- Macau University of Science and Technology,Macau, China
- College of Pharmacy, Nanjing University of Chinese Medicine,Nanjing, China
Abstract
Background: Acidic glycosphingolipids (GSLs), including gangliosides (GAs) and sulfatides (STs), play key roles in intercellular signalling and neurodegenerative diseases. However, their comprehensive characterization remains challenging because of structural complexity, abundance variation, and interference from isomers and isotopes. This study aimed to systematically profile GAs and STs in mouse brain tissues and explore their potential as biomarkers in a Parkinson’s disease (PD) model.
Methods: Prefractionation in combination with UHPLC-Q-TOF MS was employed for high-resolution MS and MS/
Results: A total of 220 acidic GSLs were characterized, including 173 GAs (21 subclasses) and 47 STs (3 subclasses), representing the most extensive profile reported from mouse brain tissues, among which 75 GAs and 29 STs are, to the best of the authors’ knowledge, newly reported here. The QSRR model provided retention time predictions supporting the tentative annotation of eight rare acidic GSLs with insufficient MS/
Conclusions: This study provides a comprehensive profile of acidic GSLs in mouse brain tissues and reveals GQ alterations with pathway disruptions in PD, offering molecular evidence linking acidic GSL metabolism to this disease.
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:32150572, at figshare; found in DataCite
Data availability
The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 12 MeSH terms, 4 funders, 70 references.
Cite
This paper
Liu, M.-y., Wang, J., Meng, X.-y., Liu, J.-r., Yao, X.-j., Wang, Y.-w., Yau, L.-f., Sun, A.-r., Mi, J.-n., Liu, L., Ren, W.-J., Kang, Y., & Wang, J.-r. (2026). Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease. Lipids in health and disease, 25(1), 123. https://
BibTeX
@article{liu2026explorat
author = {Liu, Ming-yang and Wang, Juan and Meng, Xiong-yu and Liu, Jia-ru and Yao, Xiao-jun and Wang, Yu-wei and Yau, Lee-fong and Sun, An-ran and Mi, Jia-ning and Liu, Liang and Ren, Wen-Jing and Kang, Yue and Wang, Jing-rong},
title = {{Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease}},
journal = {Lipids in health and disease},
year = {2026},
month = mar,
volume = {25},
number = {1},
pages = {123},
publisher = {BMC},
issn = {1476-511X},
doi = {10.1186/
url = {https://
pmid = {41877091},
pmcid = {PMC13137580}
}
RIS
TY - JOUR
AU - Liu, Ming-yang
AU - Wang, Juan
AU - Meng, Xiong-yu
AU - Liu, Jia-ru
AU - Yao, Xiao-jun
AU - Wang, Yu-wei
AU - Yau, Lee-fong
AU - Sun, An-ran
AU - Mi, Jia-ning
AU - Liu, Liang
AU - Ren, Wen-Jing
AU - Kang, Yue
AU - Wang, Jing-rong
TI - Exploration of the structural diversity and distribution pattern of gangliosides and sulfatides in mouse brain tissues and biomarkers for Parkinson's Disease
T2 - Lipids in health and disease
J2 - Lipids Health Dis
PY - 2026
DA - 2026/
VL - 25
IS - 1
SP - 123
SN - 1476-511X
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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