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Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis.

Overview

Authors: Jorge Díaz1,2,3, Samuel Martínez-Meza1,2,3, María Fernanda González1,2,3, Esteban Palacios1,2,3, Andrea Tapia-Bustos4, Mario Herrera-Marschitz4, Paola Morales4, Tomás Monteverde1, Gabriel Díaz-Serrano1,2,3, Ignacio Leyton-Rivera1,2,3, Alejandro Chamorro1,2,3, Ignacio A. Wichmann5,6, Rocío Artigas7,6, Alejandro Corvalán7,6, Andrew F. G. Quest1,2,3, Horacio Maldonado1,3,8, Lisette Leyton1,2,3
ORCID iDs: Jorge Díaz, Andrew F. G. Quest, Horacio Maldonado, Lisette Leyton
  1. Cell Communication Laboratory, Núcleo Interdisciplinario de Biología y Genética, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile,Santiago, 8380453 Chile
  2. Center for studies on Exercise, Metabolism and Cancer (CEMC), Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile,Santiago, 8380453 Chile
  3. Advanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina, Universidad de Chile,Santiago, 8380453 Chile
  4. Núcleo Interdisciplinario de Farmacología e Inmunología, Instituto de Ciencias Biomédicas (ICBM), Facultad de Medicina, Universidad de Chile,Santiago, 8380453 Chile
  5. Department of Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile,Santiago, 8330034 Chile
  6. Advanced Center for Chronic Diseases (ACCDiS), Pontificia Universidad Católica de Chile,Santiago, 8330034 Chile
  7. Departamento de Hematología y Oncología, School of Medicine, Pontificia Universidad Católica de Chile,Santiago, 8330034 Chile
  8. Centro de Biomedicina (CBM), Universidad Mayor,Santiago, 8580745 Chile
Institutions: University of Chile (Chile); Pontificia Universidad Católica de Chile (Chile); Universidad Mayor (Chile)
Journal: Cell communication and signaling : CCS, volume 24, issue 1, article 422
Dates: received 22 August 2025; accepted 13 February 2026; published online 9 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12964-026-02748-9 · PMID 42106708 · PMCID PMC13418144 · OpenAlex W7160696687
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), rat (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: Neuroinflammation, Endosome–lysosome pathway, Reactive astrocytes, Lysosome, RAB7 GTPase, Cell migration, Neurite outgrowth, Glial cells
MeSH: Astrocytes*, Down-Regulation*, Endosomes*, Gliosis*, Homeostasis*, Lysosomes*, Neuroinflammatory Diseases*, rab GTP-Binding Proteins*, Animals, Cell Movement, Cells, Cultured, Mice, rab7 GTP-Binding Proteins, Rats (* major topic)
Topic: Neuroscience and Neuropharmacology Research (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Agencia Nacional de Investigación y Desarrollo (FONDECYT/POSTDOCTORADO NACIONAL #3170169 (JD), CONICYT-FONDAP #15130011, Continuation #1523A0008 (AFGQ, AC), FONDECYT/POSTDOCTORADO NACIONAL #3230227, FONDECYT/PROYECTO REGULAR #1231443 (MH-M), FONDECYT/PROYECTO REGULAR #1200836 & #1240888 (LL), BECAS/DOCTORADO NACIONAL #21252379 (IL-R)); Instituto de Ciencias Biomédicas, Facultad de Medicina, University of Chile (ICBM #57419); Universidad de Talca (BECAS/DOCTORADO ESTUDIANTES EXTRANJEROS #FCS-DC-001 (GD-S))
Citations: not cited yet (Europe PMC); 87 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Data links

Data availability statement

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Read it in the paper: doi.org/10.1186/s12964-026-02748-9.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 8 keywords, 14 MeSH terms, 3 funders, 87 references.

Cite

This paper

Díaz, J., Martínez-Meza, S., González, M. F., Palacios, E., Tapia-Bustos, A., Herrera-Marschitz, M., Morales, P., Monteverde, T., Díaz-Serrano, G., Leyton-Rivera, I., Chamorro, A., Wichmann, I. A., Artigas, R., Corvalán, A., Quest, A. F. G., Maldonado, H., & Leyton, L. (2026). Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis. Cell communication and signaling : CCS, 24(1), 422. https://doi.org/10.1186/s12964-026-02748-9

BibTeX

@article{diaz2026neuroinflammation,
author = {Díaz, Jorge and Martínez-Meza, Samuel and González, María Fernanda and Palacios, Esteban and Tapia-Bustos, Andrea and Herrera-Marschitz, Mario and Morales, Paola and Monteverde, Tomás and Díaz-Serrano, Gabriel and Leyton-Rivera, Ignacio and Chamorro, Alejandro and Wichmann, Ignacio A. and Artigas, Rocío and Corvalán, Alejandro and Quest, Andrew F. G. and Maldonado, Horacio and Leyton, Lisette},
title = {{Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis}},
journal = {Cell communication and signaling : CCS},
year = {2026},
month = may,
volume = {24},
number = {1},
pages = {422},
publisher = {BMC},
issn = {1478-811X},
doi = {10.1186/s12964-026-02748-9},
url = {https://doi.org/10.1186/s12964-026-02748-9},
pmid = {42106708},
pmcid = {PMC13418144}
}

RIS

TY - JOUR
AU - Díaz, Jorge
AU - Martínez-Meza, Samuel
AU - González, María Fernanda
AU - Palacios, Esteban
AU - Tapia-Bustos, Andrea
AU - Herrera-Marschitz, Mario
AU - Morales, Paola
AU - Monteverde, Tomás
AU - Díaz-Serrano, Gabriel
AU - Leyton-Rivera, Ignacio
AU - Chamorro, Alejandro
AU - Wichmann, Ignacio A.
AU - Artigas, Rocío
AU - Corvalán, Alejandro
AU - Quest, Andrew F. G.
AU - Maldonado, Horacio
AU - Leyton, Lisette
TI - Neuroinflammation-induced downregulation of RAB7 in murine astrocytes disrupts endo-lysosomal homeostasis and induces astrogliosis
T2 - Cell communication and signaling : CCS
J2 - Cell Commun Signal
PY - 2026
DA - 2026/05/09
VL - 24
IS - 1
SP - 422
SN - 1478-811X
PB - BMC
DO - 10.1186/s12964-026-02748-9
UR - https://doi.org/10.1186/s12964-026-02748-9
LA - en
ER -

CSL-JSON

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"container-title-short": "Cell Commun Signal",
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"language": "en",
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