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Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment.

Overview

Authors: Kai-wen Cheng1,2, Shao-jun Zhou3,4, Jie Zeng2,5, Yang-rui Zhang3,4, Bing-qian Jin5, Ping Wang6, Ling-yan He7, Xu-chen Qi8, Xu-dong Liu9, Lu-shan Yu3,4, Yan-xing Zhang2,5,10
  1. Department of Medical Research Center, Shaoxing People’s Hospital, School of Medicine, ShaoXing University, Shaoxing, 312000 China
  2. Department of Neurology, Shaoxing People’s Hospital, Shaoxing, 312000 China
  3. Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China
  4. National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang University, Hangzhou, 310058 China
  5. School of Medicine, ShaoXing University, Shaoxing, 312000 China
  6. Department of Blood Transfusion, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, 312000 China
  7. Department of Traditional Chinese Medicine, Shaoxing People’s Hospital, Zhejiang University Shaoxing Hospital, Shaoxing, China
  8. Department of Neurosurgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310024 China
  9. Bioengineering College of Chongqing University, Chongqing, 400030 China
  10. State Key Laboratory of Neurology and Oncology Drug Development, Jiangsu Simcere Pharmaceutical Co. Ltd., 699-18 Xuan Wi Avemue, Nanjing, Jiangsu 210042 China
Journal: Journal of translational medicine, volume 24, issue 1, article 1029
Dates: received 16 October 2025; accepted 26 May 2026; published online 11 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12967-026-08385-7 · PMID 42277880 · PMCID PMC13465433 · OpenAlex W7164415799
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Glioblastoma multiforme, Blood-brain barrier, Dihydrotanshinone I, Apoptosis
MeSH: Brain Neoplasms*, Glioblastoma*, Phenanthrenes*, STAT3 Transcription Factor*, Animals, Apoptosis, Blood-Brain Barrier, Cell Line, Tumor, Cell Movement, Cell Proliferation, Furans, Gene Expression Regulation, Neoplastic, Humans, Male, Mice, Nude, Network Pharmacology, Quinones, Reactive Oxygen Species, Signal Transduction, Xenograft Model Antitumor Assays (* major topic)
Topic: Retinoids in leukemia and cellular processes (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Shaoxing Bureau of Science and Technology (2023A14023, 2024A14017); Medical Science and Technology Project of Zhejiang Province (2025KY381, 2026HY1286)
Citations: not cited yet (Europe PMC); 76 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12967-026-08385-7.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 4 keywords, 20 MeSH terms, 2 funders, 76 references.

Cite

This paper

Cheng, K.-w., Zhou, S.-j., Zeng, J., Zhang, Y.-r., Jin, B.-q., Wang, P., He, L.-y., Qi, X.-c., Liu, X.-d., Yu, L.-s., & Zhang, Y.-x. (2026). Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment. Journal of translational medicine, 24(1), 1029. https://doi.org/10.1186/s12967-026-08385-7

BibTeX

@article{cheng2026dihydrotanshinone,
author = {Cheng, Kai-wen and Zhou, Shao-jun and Zeng, Jie and Zhang, Yang-rui and Jin, Bing-qian and Wang, Ping and He, Ling-yan and Qi, Xu-chen and Liu, Xu-dong and Yu, Lu-shan and Zhang, Yan-xing},
title = {{Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment}},
journal = {Journal of translational medicine},
year = {2026},
month = jun,
volume = {24},
number = {1},
pages = {1029},
publisher = {BMC},
issn = {1479-5876},
doi = {10.1186/s12967-026-08385-7},
url = {https://doi.org/10.1186/s12967-026-08385-7},
pmid = {42277880},
pmcid = {PMC13465433}
}

RIS

TY - JOUR
AU - Cheng, Kai-wen
AU - Zhou, Shao-jun
AU - Zeng, Jie
AU - Zhang, Yang-rui
AU - Jin, Bing-qian
AU - Wang, Ping
AU - He, Ling-yan
AU - Qi, Xu-chen
AU - Liu, Xu-dong
AU - Yu, Lu-shan
AU - Zhang, Yan-xing
TI - Dihydrotanshinone I as a novel signal transducer and activator of transcription 3 inhibitor for glioblastoma treatment
T2 - Journal of translational medicine
J2 - J Transl Med
PY - 2026
DA - 2026/06/11
VL - 24
IS - 1
SP - 1029
SN - 1479-5876
PB - BMC
DO - 10.1186/s12967-026-08385-7
UR - https://doi.org/10.1186/s12967-026-08385-7
LA - en
ER -

CSL-JSON

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