Clostridium butyricum ameliorates Toxoplasma gondii-induced neuropsychiatric disorders by attenuating glial-mediated synaptic pruning via the gut-brain axis.

Overview

Authors: Yiling Li^1,2, Hongjin Wu^1,2, Jiayi Yang^1,2, Jensen G Weedor¹, Haoxuan Ding^1,2, Wenjing Cui¹, Bingqian Cui^1,2, Zhicheng He^1,2, Wenjun Zhang¹, Yihui Xing¹, Fan Zeng¹, Xufeng Huang^1,3, Kuiyang Zheng¹, Yujuan Shen⁴, Yinghua Yu¹, Wei Pan¹, Xiaoying Yang¹

ORCID iDs: Hongjin Wu, Xufeng Huang

Jiangsu Key Laboratory of Immunity and Metabolism, Jiangsu International Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University,Xuzhou, Jiangsu China
The First Clinical Medical College, Xuzhou Medical University,Xuzhou, Jiangsu China
Illawarra Health and Medical Research Institute (IHMRI), University of Wollongong,Wollongong, NSW 2522 Australia
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases,Shanghai, China

Institutions: Xuzhou Medical College (China); University of Wollongong (Australia); Chinese Center For Disease Control and Prevention (China)

Journal: Journal of neuroinflammation, volume 23, issue 1, article 177

Dates: received 28 July 2025; accepted 28 February 2026; published online 10 April 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1186/s12974-026-03761-y · PMID 41963962 · PMCID PMC13214200 · OpenAlex W7153091212

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: human (organism), mouse (organism), cellular / molecular (subfield)

Methods: Spectral & time-frequency, Statistics, Machine learning, Connectivity

MeSH: Brain*, Brain-Gut Axis*, Clostridium butyricum*, Gastrointestinal Microbiome*, Mental Disorders*, Neuroglia*, Neuronal Plasticity*, Toxoplasmosis*, Animals, Dysbiosis, Fecal Microbiota Transplantation, Humans, Male, Mice, Mice, Inbred C57BL, Toxoplasma (* major topic)

Topic: Toxoplasma gondii Research Studies (Parasitology, Immunology and Microbiology), according to OpenAlex

Funding: Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province (Nos. 202310313083Y, Nos. X202510313020, Nos. X202510313017); Faculty Development Grant of Basic Medical Sciences in Xuzhou Medical University (No. JC20250007); Open competition Grant of Xuzhou Medical University; National Natural Science Foundation of China (Nos. 82372283); 333, High-level Talent Training Project of Jiangsu Province; XZHMU-QL Joint Research Fund (No. QL-YB022); Jiangsu Qinglan Project; China Postdoctoral Science Foundation (No. 2022M710120)

Citations: not cited yet (Europe PMC); 77 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

bioproject:PRJNA1290700, at NCBI BioProject; found in “Data availability”

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

it points to a dataset: NCBI BioProject PRJNA1290700

Read it in the paper: doi.org/10.1186/s12974-026-03761-y.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 16 MeSH terms, 8 funders, 77 references.

Cite

This paper

Li, Y., Wu, H., Yang, J., Weedor, J. G., Ding, H., Cui, W., Cui, B., He, Z., Zhang, W., Xing, Y., Zeng, F., Huang, X., Zheng, K., Shen, Y., Yu, Y., Pan, W., & Yang, X. (2026). Clostridium butyricum ameliorates Toxoplasma gondii-induced neuropsychiatric disorders by attenuating glial-mediated synaptic pruning via the gut-brain axis. Journal of neuroinflammation, 23(1), 177. https://doi.org/10.1186/s12974-026-03761-y

BibTeX

@article{li2026clostridium, author = {Li, Yiling and Wu, Hongjin and Yang, Jiayi and Weedor, Jensen G and Ding, Haoxuan and Cui, Wenjing and Cui, Bingqian and He, Zhicheng and Zhang, Wenjun and Xing, Yihui and Zeng, Fan and Huang, Xufeng and Zheng, Kuiyang and Shen, Yujuan and Yu, Yinghua and Pan, Wei and Yang, Xiaoying}, title = {{Clostridium butyricum ameliorates Toxoplasma gondii-induced neuropsychiatric disorders by attenuating glial-mediated synaptic pruning via the gut-brain axis}}, journal = {Journal of neuroinflammation}, year = {2026}, month = apr, volume = {23}, number = {1}, pages = {177}, publisher = {BMC}, issn = {1742-2094}, doi = {10.1186/s12974-026-03761-y}, url = {https://doi.org/10.1186/s12974-026-03761-y}, pmid = {41963962}, pmcid = {PMC13214200} }

RIS

TY - JOUR AU - Li, Yiling AU - Wu, Hongjin AU - Yang, Jiayi AU - Weedor, Jensen G AU - Ding, Haoxuan AU - Cui, Wenjing AU - Cui, Bingqian AU - He, Zhicheng AU - Zhang, Wenjun AU - Xing, Yihui AU - Zeng, Fan AU - Huang, Xufeng AU - Zheng, Kuiyang AU - Shen, Yujuan AU - Yu, Yinghua AU - Pan, Wei AU - Yang, Xiaoying TI - Clostridium butyricum ameliorates Toxoplasma gondii-induced neuropsychiatric disorders by attenuating glial-mediated synaptic pruning via the gut-brain axis T2 - Journal of neuroinflammation J2 - J Neuroinflammation PY - 2026 DA - 2026/04/10 VL - 23 IS - 1 SP - 177 SN - 1742-2094 PB - BMC DO - 10.1186/s12974-026-03761-y UR - https://doi.org/10.1186/s12974-026-03761-y LA - en ER -

CSL-JSON

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