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PTP1B in astrocytes drives pathogen-induced neurodegeneration.

Overview

Authors: Zhicheng He1,2, Yihui Xing1, Jianqi Gu1,2, Daxiang Xu1, Peixuan He1, Xiaoqian Lin3,4, Wenjing Cui1, Huiling Lv1, Haoxuan Ding1,2, Kai Sui1, Wenting Hao1, Yutao Zheng1, Xiaoying Yang1, Xufeng Huang5, Kun Yin6, Cheng He1, Kuiyang Zheng1, Yinghua Yu1, Wei Pan1
ORCID iDs: Xufeng Huang, Yinghua Yu
  1. Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu 221004 China
  2. The First Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu China
  3. Nanjing Medical University, Nanjing, Jiangsu Province 211166 China
  4. Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province 221002 China
  5. Illawarra Health and Medical Research Institue (IHMRI) and School of Medicine, University of Wollongong, Wollongong, NSW 2522 Australia
  6. Shandong Institute of Parasitic Diseases, Shandong First Medical University & Shandong Academy of Medical Sciences, Jining, Shandong 272033 China
Institutions: Xuzhou Medical College (China); Affiliated Hospital of Xuzhou Medical College (China); Nanjing Medical University (China); Shandong First Medical University (China)
Journal: Journal of neuroinflammation, volume 23, issue 1, article 205
Dates: received 5 December 2025; accepted 21 April 2026; published online 29 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03837-9 · PMID 42057007 · PMCID PMC13281436 · OpenAlex W7158459996
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Toxoplasma gondii, Cognitive impairment, PTP1B, A1-like neurotoxic reactive astrocytes, Neuronal senescence
MeSH: Astrocytes*, Neurodegenerative Diseases*, Protein Tyrosine Phosphatase, Non-Receptor Type 1*, Toxoplasmosis*, Animals, Female, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Neurons, Toxoplasma (* major topic)
Topic: Toxoplasma gondii Research Studies (Parasitology, Immunology and Microbiology), according to OpenAlex
Funding: the XZHMU-QL Joint Research Fund (No. QL-YB022); Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province (202410313045Y); National Natural Science Foundation of China (No. 82302557); Natural Science Foundation of Jiangsu Province (No. BK20201459); Open competition Grant of Xuzhou Medical University; the 333 High-level Talent Training Project of Jiangsu Province; the Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province (202510313019)
Citations: cited by 1 paper (Europe PMC); 123 references in the paper
Research resources: GfapCre/+ mice RRID:IMSR_JAX:004600, Ptp1bfl/fl mice RRID:MMRRC_032243-JAX

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1186/s12974-026-03837-9.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 5 keywords, 12 MeSH terms, 7 funders, 123 references, 2 RRIDs.

Cite

This paper

He, Z., Xing, Y., Gu, J., Xu, D., He, P., Lin, X., Cui, W., Lv, H., Ding, H., Sui, K., Hao, W., Zheng, Y., Yang, X., Huang, X., Yin, K., He, C., Zheng, K., Yu, Y., & Pan, W. (2026). PTP1B in astrocytes drives pathogen-induced neurodegeneration. Journal of neuroinflammation, 23(1), 205. https://doi.org/10.1186/s12974-026-03837-9

BibTeX

@article{he2026ptp1b,
author = {He, Zhicheng and Xing, Yihui and Gu, Jianqi and Xu, Daxiang and He, Peixuan and Lin, Xiaoqian and Cui, Wenjing and Lv, Huiling and Ding, Haoxuan and Sui, Kai and Hao, Wenting and Zheng, Yutao and Yang, Xiaoying and Huang, Xufeng and Yin, Kun and He, Cheng and Zheng, Kuiyang and Yu, Yinghua and Pan, Wei},
title = {{PTP1B in astrocytes drives pathogen-induced neurodegeneration}},
journal = {Journal of neuroinflammation},
year = {2026},
month = apr,
volume = {23},
number = {1},
pages = {205},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03837-9},
url = {https://doi.org/10.1186/s12974-026-03837-9},
pmid = {42057007},
pmcid = {PMC13281436}
}

RIS

TY - JOUR
AU - He, Zhicheng
AU - Xing, Yihui
AU - Gu, Jianqi
AU - Xu, Daxiang
AU - He, Peixuan
AU - Lin, Xiaoqian
AU - Cui, Wenjing
AU - Lv, Huiling
AU - Ding, Haoxuan
AU - Sui, Kai
AU - Hao, Wenting
AU - Zheng, Yutao
AU - Yang, Xiaoying
AU - Huang, Xufeng
AU - Yin, Kun
AU - He, Cheng
AU - Zheng, Kuiyang
AU - Yu, Yinghua
AU - Pan, Wei
TI - PTP1B in astrocytes drives pathogen-induced neurodegeneration
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/04/29
VL - 23
IS - 1
SP - 205
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03837-9
UR - https://doi.org/10.1186/s12974-026-03837-9
LA - en
ER -

CSL-JSON

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