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SGK1 inhibition supports neuroprotection in spinal cord injury by suppressing oxidative stress and AIM2 activation via FoxO1 mediated mitophagy.

Overview

Authors: Yige Chen1, Yikang Wang1, Nongtao Fang1, Jiawei Xu1, Yiwei Teng2, Ke Wang1, Longze Huang1, Haifen Ni3, Yongli Wang1, Kailiang Zhou1, Yan Lin1, Yao Li1
ORCID iDs: Yao Li
  1. Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000 China
  2. Wenzhou Medical University Renji College, Wenzhou, Zhejiang China
  3. Department of Physical Examination Center, Dongtou District People’s Hospital, Wenzhou, Zhejiang China
Journal: Journal of neuroinflammation, volume 23, issue 1, article 204
Dates: received 27 December 2025; accepted 25 April 2026; published online 2 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03844-w · PMID 42067867 · PMCID PMC13281299 · OpenAlex W7159829375
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Serum and glucocorticoid-regulated kinase 1, Mitochondria, Absent in melanoma 2, Spinal cord injury, Inflammasome
MeSH: Forkhead Box Protein O1*, Immediate-Early Proteins*, Mitophagy*, Neuroprotection*, Oxidative Stress*, Protein Serine-Threonine Kinases*, Spinal Cord Injuries*, Animals, Benzoates, Bridged Bicyclo Compounds, Heterocyclic, Female, Male, Mice, Mice, Inbred C57BL, Microglia, Serum-Glucocorticoid Regulated Kinases (* major topic)
Topic: FOXO transcription factor regulation (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82102674); Zhejiang Province Medical and Health Science and Technology Program (2024KY1288)
Citations: cited by 6 papers (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1186/s12974-026-03844-w.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 5 keywords, 16 MeSH terms, 2 funders, 50 references.

Cite

This paper

Chen, Y., Wang, Y., Fang, N., Xu, J., Teng, Y., Wang, K., Huang, L., Ni, H., Wang, Y., Zhou, K., Lin, Y., & Li, Y. (2026). SGK1 inhibition supports neuroprotection in spinal cord injury by suppressing oxidative stress and AIM2 activation via FoxO1 mediated mitophagy. Journal of neuroinflammation, 23(1), 204. https://doi.org/10.1186/s12974-026-03844-w

BibTeX

@article{chen2026sgk1,
author = {Chen, Yige and Wang, Yikang and Fang, Nongtao and Xu, Jiawei and Teng, Yiwei and Wang, Ke and Huang, Longze and Ni, Haifen and Wang, Yongli and Zhou, Kailiang and Lin, Yan and Li, Yao},
title = {{SGK1 inhibition supports neuroprotection in spinal cord injury by suppressing oxidative stress and AIM2 activation via FoxO1 mediated mitophagy}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {204},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03844-w},
url = {https://doi.org/10.1186/s12974-026-03844-w},
pmid = {42067867},
pmcid = {PMC13281299}
}

RIS

TY - JOUR
AU - Chen, Yige
AU - Wang, Yikang
AU - Fang, Nongtao
AU - Xu, Jiawei
AU - Teng, Yiwei
AU - Wang, Ke
AU - Huang, Longze
AU - Ni, Haifen
AU - Wang, Yongli
AU - Zhou, Kailiang
AU - Lin, Yan
AU - Li, Yao
TI - SGK1 inhibition supports neuroprotection in spinal cord injury by suppressing oxidative stress and AIM2 activation via FoxO1 mediated mitophagy
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/02
VL - 23
IS - 1
SP - 204
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03844-w
UR - https://doi.org/10.1186/s12974-026-03844-w
LA - en
ER -

CSL-JSON

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