OSCR

IFI204 drives gasdermin D-mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke.

Overview

Authors: Pengfei Xu1, Nan Shen1, Tian Qiu1, Mingyue Zhou1, Rui Li1, Chunrong Tao1, Yuyou Zhu1, Wei Hu1
  1. Department of Neurology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001 China
Journal: Journal of neuroinflammation, volume 23, issue 1, article 238
Dates: received 19 January 2026; accepted 27 April 2026; published online 11 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03847-7 · PMID 42116053 · PMCID PMC13343725 · OpenAlex W7160863202
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Graphs
Keywords: IFI204, Pyroptosis, GSDMD, Mitochondrial DNA (mtDNA), Ischemic stroke, Neuroinflammation
MeSH: Intracellular Signaling Peptides and Proteins*, Ischemic Stroke*, Mitochondria*, Neurons*, Phosphate-Binding Proteins*, Pyroptosis*, Animals, cGAS-STING Signaling Pathway, Gasdermins, Infarction, Middle Cerebral Artery, Male, Mice, Mice, Inbred C57BL, Mice, Knockout (* major topic)
Topic: Inflammasome and immune disorders (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82471310, 82471311); Natural Science Foundation of Anhui Province (2408085MH214)
Citations: not cited yet (Europe PMC); 56 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12974-026-03847-7.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 14 MeSH terms, 2 funders, 56 references.

Cite

This paper

Xu, P., Shen, N., Qiu, T., Zhou, M., Li, R., Tao, C., Zhu, Y., & Hu, W. (2026). IFI204 drives gasdermin D-mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke. Journal of neuroinflammation, 23(1), 238. https://doi.org/10.1186/s12974-026-03847-7

BibTeX

@article{xu2026ifi204,
author = {Xu, Pengfei and Shen, Nan and Qiu, Tian and Zhou, Mingyue and Li, Rui and Tao, Chunrong and Zhu, Yuyou and Hu, Wei},
title = {{IFI204 drives gasdermin D-mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {238},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03847-7},
url = {https://doi.org/10.1186/s12974-026-03847-7},
pmid = {42116053},
pmcid = {PMC13343725}
}

RIS

TY - JOUR
AU - Xu, Pengfei
AU - Shen, Nan
AU - Qiu, Tian
AU - Zhou, Mingyue
AU - Li, Rui
AU - Tao, Chunrong
AU - Zhu, Yuyou
AU - Hu, Wei
TI - IFI204 drives gasdermin D-mediated mitochondrial permeabilization to amplify neuronal pyroptosis in ischemic stroke
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/11
VL - 23
IS - 1
SP - 238
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03847-7
UR - https://doi.org/10.1186/s12974-026-03847-7
LA - en
ER -

CSL-JSON

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"author": [
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"PMID": "42116053",
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"ISSN": "1742-2094",
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"URL": "https://doi.org/10.1186/s12974-026-03847-7",
"language": "en",
"issued": {
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}

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