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Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease.

Overview

Authors: Yaochen Cao1,2, Jingyun Wang3, Xitong Li2,3, Xin Chen2, Jinsheng Xiong3,4, Tianyao Wang5, Hongming Sun6, Ziqiang Wang1,7
  1. Department of Medicine, Hainan Medical University, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou, Hannan 570102 China
  2. Department of Nephrology, Charité-Universitätsmedizin Berlin, Campus Mitte, Berlin, 10117 Germany
  3. Fifth Department of Medicine (Nephrology/Endocrinology/Rheumatology/Pneumology), University Medical Centre Mannheim, University of Heidelberg, Heidelberg, Germany
  4. Department of Neurosurgery, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
  5. Department of Anesthesiology, Cancer Hospital Affiliated to Harbin Medical University, Harbin, China
  6. Department of Neurology, Daping Hospital, Third Military Medical University, No. 30 Gaotanyanzheng Street, Shapingba District, Chongqing, 400042 China
  7. Department of Nephrology, The First Affiliated Hospital of Hainan Medical University, No. 31 Longhua Road, Haikou, Hainan Province 570102 China
Journal: Journal of neuroinflammation, volume 23, issue 1, article 252
Dates: received 21 August 2025; accepted 29 April 2026; published online 25 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03852-w · PMID 42178562 · PMCID PMC13377755 · OpenAlex W7162260348
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: rat (organism), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, fMRI & imaging
Keywords: Chronic kidney disease, Cognitive impairment, Microglia, Synaptic phagocytosis, Ccl4-Ccr5 axis, Neuroinflammation
MeSH: Inflammation*, Memory Disorders*, Microglia*, Receptors, CCR5*, Renal Insufficiency, Chronic*, Synapses*, Animals, Hippocampus, Male, Rats, Rats, Sprague-Dawley, Signal Transduction (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (No. 82360151); Academic Enhancement Support Program of Hainan Medical University (XSTS2025101)
Citations: not cited yet (Europe PMC); 69 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1186/s12974-026-03852-w.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 12 MeSH terms, 2 funders, 69 references.

Cite

This paper

Cao, Y., Wang, J., Li, X., Chen, X., Xiong, J., Wang, T., Sun, H., & Wang, Z. (2026). Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease. Journal of neuroinflammation, 23(1), 252. https://doi.org/10.1186/s12974-026-03852-w

BibTeX

@article{cao2026microglial,
author = {Cao, Yaochen and Wang, Jingyun and Li, Xitong and Chen, Xin and Xiong, Jinsheng and Wang, Tianyao and Sun, Hongming and Wang, Ziqiang},
title = {{Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease}},
journal = {Journal of neuroinflammation},
year = {2026},
month = may,
volume = {23},
number = {1},
pages = {252},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03852-w},
url = {https://doi.org/10.1186/s12974-026-03852-w},
pmid = {42178562},
pmcid = {PMC13377755}
}

RIS

TY - JOUR
AU - Cao, Yaochen
AU - Wang, Jingyun
AU - Li, Xitong
AU - Chen, Xin
AU - Xiong, Jinsheng
AU - Wang, Tianyao
AU - Sun, Hongming
AU - Wang, Ziqiang
TI - Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/05/25
VL - 23
IS - 1
SP - 252
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03852-w
UR - https://doi.org/10.1186/s12974-026-03852-w
LA - en
ER -

CSL-JSON

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"title": "Microglial Ccl4-Ccr5 signaling links systemic inflammation to synaptic loss and memory deficits in chronic kidney disease",
"container-title": "Journal of neuroinflammation",
"author": [
{
"family": "Cao",
"given": "Yaochen"
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"container-title-short": "J Neuroinflammation",
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"page": "252",
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"PMID": "42178562",
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"ISSN": "1742-2094",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12974-026-03852-w",
"language": "en",
"issued": {
"date-parts": [
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}

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