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TGR5 is essential for protecting from chronic stress-induced learning and memory impairments in mice by modulating inflammation associated with the gut-brain axis.

Overview

Authors: Shuai Zhang1, Xiaoyang Liu1, Hao Xu1, Wenqian Zhang2, Chenchen Shi2, Meimei Wang1, Guangmin Zhang1, Xin Cheng1, Xuanpan Ding1, Haoyang Tan1, Yuan Zhao1, Honggang Fan1, Guiyan Yang2
  1. Heilongjiang Provincial Key Laboratory of Pathogenic Mechanism for Animal Disease and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University,Harbin, 150036 PR China
  2. State Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University,Beijing, 100193 PR China
Journal: Journal of neuroinflammation, volume 23, issue 1, article 273
Dates: received 21 January 2026; accepted 29 May 2026; published online 2 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03898-w · PMID 42231452 · PMCID PMC13483826 · OpenAlex W7163201862
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), histology / microscopy (modality), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Machine learning
Keywords: TGR5, Chronic stress, Gut-brain axis, Cognitive impairment, Inflammation
MeSH: Brain-Gut Axis*, Memory Disorders*, Receptors, G-Protein-Coupled*, Stress, Psychological*, Animals, Brain, Gastrointestinal Microbiome, Hippocampus, Inflammation, Male, Mice, Mice, Inbred C57BL, Mice, Knockout (* major topic)
Topic: Gut microbiota and health (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Program for Young Talents of Basic Research in Universities of Heilongjiang Province (Grant No. YQJH2024013); Key Project of the Natural Science Foundation of Heilongjiang Province (Grant No. ZL2024C020); Beijing-Tianjin-Hebei Natural Science Foundation Cooperation Project (Grant No. 25JJJJC0042); National Natural Science Foundation of China (Grant No. 32573438)
Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Data links

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI
  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12974-026-03898-w.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 13 MeSH terms, 4 funders, 87 references.

Cite

This paper

Zhang, S., Liu, X., Xu, H., Zhang, W., Shi, C., Wang, M., Zhang, G., Cheng, X., Ding, X., Tan, H., Zhao, Y., Fan, H., & Yang, G. (2026). TGR5 is essential for protecting from chronic stress-induced learning and memory impairments in mice by modulating inflammation associated with the gut-brain axis. Journal of neuroinflammation, 23(1), 273. https://doi.org/10.1186/s12974-026-03898-w

BibTeX

@article{zhang2026tgr5,
author = {Zhang, Shuai and Liu, Xiaoyang and Xu, Hao and Zhang, Wenqian and Shi, Chenchen and Wang, Meimei and Zhang, Guangmin and Cheng, Xin and Ding, Xuanpan and Tan, Haoyang and Zhao, Yuan and Fan, Honggang and Yang, Guiyan},
title = {{TGR5 is essential for protecting from chronic stress-induced learning and memory impairments in mice by modulating inflammation associated with the gut-brain axis}},
journal = {Journal of neuroinflammation},
year = {2026},
month = jun,
volume = {23},
number = {1},
pages = {273},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03898-w},
url = {https://doi.org/10.1186/s12974-026-03898-w},
pmid = {42231452},
pmcid = {PMC13483826}
}

RIS

TY - JOUR
AU - Zhang, Shuai
AU - Liu, Xiaoyang
AU - Xu, Hao
AU - Zhang, Wenqian
AU - Shi, Chenchen
AU - Wang, Meimei
AU - Zhang, Guangmin
AU - Cheng, Xin
AU - Ding, Xuanpan
AU - Tan, Haoyang
AU - Zhao, Yuan
AU - Fan, Honggang
AU - Yang, Guiyan
TI - TGR5 is essential for protecting from chronic stress-induced learning and memory impairments in mice by modulating inflammation associated with the gut-brain axis
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/06/02
VL - 23
IS - 1
SP - 273
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03898-w
UR - https://doi.org/10.1186/s12974-026-03898-w
LA - en
ER -

CSL-JSON

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