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Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology.

Overview

Authors: Margaret Hayne1, Joanna Lipka1, Tawaun A Lucas2, Allison L Soung1, Max Adrian3, Soumitra Ghosh1, Han Lin1, Sarah Chu1, Kimberly Stark1, Hai Ngu3, Oded Foreman3, Joshua Kaminker2, Casper C Hoogenraad1
  1. Department of Neuroscience, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080 USA
  2. gRED Computational Sciences, Genentech, Inc., South San Francisco, CA 94080 USA
  3. Department of Research Pathology, Genentech, Inc., South San Francisco, CA 94080 USA
Institutions: Genentech
Journal: Journal of neuroinflammation, volume 23, issue 1, article 313
Dates: received 17 January 2026; accepted 3 June 2026; published online 27 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12974-026-03910-3 · PMID 42374481 · PMCID PMC13576294 · OpenAlex W7166590826
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), Parkinson's (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing
Keywords: SPG11, Hereditary spastic paraplegia, Synucleinopathy, Microglia, Neuroinflammation, Lipid metabolism
MeSH: alpha-Synuclein*, Lipid Metabolism*, Mesencephalon*, Myeloid Cells*, Neuroinflammatory Diseases*, Proteins*, Animals, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Microglia (* major topic)
Topic: Hereditary Neurological Disorders (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 67 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12974-026-03910-3.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 6 keywords, 13 MeSH terms, 65 references.

Cite

This paper

Hayne, M., Lipka, J., Lucas, T. A., Soung, A. L., Adrian, M., Ghosh, S., Lin, H., Chu, S., Stark, K., Ngu, H., Foreman, O., Kaminker, J., & Hoogenraad, C. C. (2026). Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology. Journal of neuroinflammation, 23(1), 313. https://doi.org/10.1186/s12974-026-03910-3

BibTeX

@article{hayne2026hereditary,
author = {Hayne, Margaret and Lipka, Joanna and Lucas, Tawaun A and Soung, Allison L and Adrian, Max and Ghosh, Soumitra and Lin, Han and Chu, Sarah and Stark, Kimberly and Ngu, Hai and Foreman, Oded and Kaminker, Joshua and Hoogenraad, Casper C},
title = {{Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology}},
journal = {Journal of neuroinflammation},
year = {2026},
month = jun,
volume = {23},
number = {1},
pages = {313},
publisher = {BMC},
issn = {1742-2094},
doi = {10.1186/s12974-026-03910-3},
url = {https://doi.org/10.1186/s12974-026-03910-3},
pmid = {42374481},
pmcid = {PMC13576294}
}

RIS

TY - JOUR
AU - Hayne, Margaret
AU - Lipka, Joanna
AU - Lucas, Tawaun A
AU - Soung, Allison L
AU - Adrian, Max
AU - Ghosh, Soumitra
AU - Lin, Han
AU - Chu, Sarah
AU - Stark, Kimberly
AU - Ngu, Hai
AU - Foreman, Oded
AU - Kaminker, Joshua
AU - Hoogenraad, Casper C
TI - Hereditary spastic paraplegia (HSP) gene 11 (Spg11) attenuates lipid accumulation in myeloid cells and neuroinflammation in the midbrain without affecting α-synuclein pathology
T2 - Journal of neuroinflammation
J2 - J Neuroinflammation
PY - 2026
DA - 2026/06/27
VL - 23
IS - 1
SP - 313
SN - 1742-2094
PB - BMC
DO - 10.1186/s12974-026-03910-3
UR - https://doi.org/10.1186/s12974-026-03910-3
LA - en
ER -

CSL-JSON

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